ENSG00000143079

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271277 ENSG00000143079 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2NL protein_coding protein_coding 3.922342 1.532716 5.918343 0.06146928 0.3984428 1.942156 2.8748727 1.47905231 4.130901 0.06128398 0.2512704 1.475550 0.78443750 0.96536667 0.7096667 -0.25570000 0.02082817 0.0160474 FALSE TRUE
ENST00000441739 ENSG00000143079 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2NL protein_coding protein_coding 3.922342 1.532716 5.918343 0.06146928 0.3984428 1.942156 0.8078518 0.00000000 1.182176 0.00000000 0.5960026 6.897454 0.13304167 0.00000000 0.1876667 0.18766667 0.34023026 0.0160474 FALSE TRUE
MSTRG.1811.1 ENSG00000143079 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2NL protein_coding   3.922342 1.532716 5.918343 0.06146928 0.3984428 1.942156 0.2307638 0.03632565 0.605266 0.03632565 0.0322157 3.731327 0.07235417 0.02413333 0.1026667 0.07853333 0.01604740 0.0160474 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143079 E001 9.0926187 0.0018758250 1.005341e-01 1.912603e-01 1 112396214 112396272 59 + 0.966 0.863 -0.392
ENSG00000143079 E002 0.4772466 0.0219866395 1.434465e-01 2.527061e-01 1 112396519 112396585 67 + 0.068 0.353 2.899
ENSG00000143079 E003 25.7506707 0.0186135752 1.735249e-01 2.927697e-01 1 112412194 112412317 124 + 1.370 1.339 -0.107
ENSG00000143079 E004 0.0000000       1 112414717 112414907 191 +      
ENSG00000143079 E005 0.0000000       1 112415833 112416156 324 +      
ENSG00000143079 E006 25.7894452 0.0256174861 2.858923e-01 4.262640e-01 1 112416157 112416264 108 + 1.367 1.361 -0.019
ENSG00000143079 E007 0.0000000       1 112416265 112416287 23 +      
ENSG00000143079 E008 32.9051089 0.0481026943 9.885911e-02 1.887363e-01 1 112448942 112449172 231 + 1.487 1.389 -0.338
ENSG00000143079 E009 19.5597459 0.0132573014 1.565891e-01 2.705581e-01 1 112454449 112454556 108 + 1.260 1.223 -0.130
ENSG00000143079 E010 99.6844175 0.0003219416 6.389570e-09 8.176175e-08 1 112455931 112456817 887 + 1.963 1.850 -0.379
ENSG00000143079 E011 75.9273819 0.0003892066 2.912713e-04 1.344258e-03 1 112456818 112457374 557 + 1.834 1.788 -0.155
ENSG00000143079 E012 254.1877910 0.0160156958 6.698808e-07 5.775321e-06 1 112457375 112461164 3790 + 2.251 2.542 0.972
ENSG00000143079 E013 3.8083532 0.0040673454 4.877771e-01 6.254173e-01 1 112462555 112463456 902 + 0.640 0.617 -0.100