ENSG00000143033

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370298 ENSG00000143033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF2 protein_coding protein_coding 22.9423 7.11987 38.8519 0.2598335 0.5241478 2.446409 13.73909186 4.5979642 23.07463686 0.3630762 0.70553654 2.324732 0.62689583 0.64443333 0.5944000000 -0.05003333 6.633047e-01 2.533481e-14 FALSE TRUE
ENST00000473430 ENSG00000143033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF2 protein_coding processed_transcript 22.9423 7.11987 38.8519 0.2598335 0.5241478 2.446409 3.13305559 0.0000000 5.08677743 0.0000000 0.57140838 8.993442 0.08290833 0.00000000 0.1313666667 0.13136667 2.533481e-14 2.533481e-14 FALSE FALSE
ENST00000476037 ENSG00000143033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF2 protein_coding processed_transcript 22.9423 7.11987 38.8519 0.2598335 0.5241478 2.446409 0.13185695 0.5205336 0.03588365 0.3832755 0.01818308 -3.531392 0.01915417 0.07010000 0.0009333333 -0.06916667 9.835834e-02 2.533481e-14 FALSE TRUE
ENST00000494963 ENSG00000143033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF2 protein_coding processed_transcript 22.9423 7.11987 38.8519 0.2598335 0.5241478 2.446409 1.44348641 0.0000000 3.89306309 0.0000000 1.12565544 8.608463 0.04272917 0.00000000 0.0995000000 0.09950000 2.146070e-07 2.533481e-14 FALSE FALSE
ENST00000540243 ENSG00000143033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF2 protein_coding protein_coding 22.9423 7.11987 38.8519 0.2598335 0.5241478 2.446409 0.07531118 0.3418588 0.00000000 0.3418588 0.00000000 -5.136925 0.01466250 0.05173333 0.0000000000 -0.05173333 5.469362e-01 2.533481e-14 FALSE TRUE
MSTRG.1618.4 ENSG00000143033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTF2 protein_coding   22.9423 7.11987 38.8519 0.2598335 0.5241478 2.446409 0.25515860 0.7592931 0.13422607 0.3849560 0.13422607 -2.415201 0.03207917 0.10306667 0.0035333333 -0.09953333 2.383592e-01 2.533481e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000143033 E001 0.2987644 0.0271862540 1.000000e+00   1 93079235 93079246 12 + 0.109 0.000 -10.723
ENSG00000143033 E002 0.6256415 0.0175329894 7.272916e-01 8.200648e-01 1 93079247 93079249 3 + 0.155 0.241 0.795
ENSG00000143033 E003 1.0653123 0.0117639091 7.906370e-01 8.660877e-01 1 93079250 93079257 8 + 0.269 0.241 -0.205
ENSG00000143033 E004 2.2508051 0.0144073691 6.131620e-01 7.319451e-01 1 93079258 93079269 12 + 0.455 0.395 -0.321
ENSG00000143033 E005 3.8750487 0.0051205148 8.266132e-01 8.909082e-01 1 93079270 93079282 13 + 0.586 0.673 0.380
ENSG00000143033 E006 4.7587704 0.0033948647 7.562282e-01 8.413505e-01 1 93079283 93079286 4 + 0.673 0.673 0.002
ENSG00000143033 E007 5.9327236 0.0026742420 3.616106e-01 5.059979e-01 1 93079287 93079288 2 + 0.767 0.673 -0.385
ENSG00000143033 E008 22.0605932 0.0008368528 9.525840e-02 1.832645e-01 1 93079289 93079295 7 + 1.278 1.179 -0.349
ENSG00000143033 E009 50.1348397 0.0004793260 3.821628e-02 8.775815e-02 1 93079296 93079309 14 + 1.617 1.546 -0.241
ENSG00000143033 E010 50.4680595 0.0004920622 4.897271e-02 1.073315e-01 1 93079310 93079310 1 + 1.618 1.555 -0.215
ENSG00000143033 E011 158.4653274 0.0002496335 6.796645e-05 3.703417e-04 1 93079311 93079531 221 + 2.110 2.027 -0.279
ENSG00000143033 E012 0.0000000       1 93080965 93081019 55 +      
ENSG00000143033 E013 64.0074098 0.0030966901 2.285254e-04 1.085566e-03 1 93110230 93110231 2 + 1.737 1.555 -0.619
ENSG00000143033 E014 73.0081525 0.0018591024 3.676043e-05 2.137621e-04 1 93110232 93110245 14 + 1.794 1.606 -0.636
ENSG00000143033 E015 60.3544148 0.0010476059 4.004581e-06 2.912754e-05 1 93110246 93110246 1 + 1.719 1.477 -0.826
ENSG00000143033 E016 103.2049698 0.0036059564 3.603193e-05 2.099511e-04 1 93110247 93110326 80 + 1.939 1.771 -0.569
ENSG00000143033 E017 126.1416530 0.0007723074 2.184764e-05 1.342296e-04 1 93110327 93110423 97 + 2.019 1.897 -0.409
ENSG00000143033 E018 54.9414412 0.0020332151 1.517734e-02 4.088997e-02 1 93110424 93110428 5 + 1.661 1.564 -0.329
ENSG00000143033 E019 108.7697211 0.0009584189 6.655975e-03 2.032978e-02 1 93110545 93110626 82 + 1.946 1.885 -0.204
ENSG00000143033 E020 1.7714822 0.0079600500 5.515184e-02 1.182562e-01 1 93110627 93110630 4 + 0.433 0.000 -13.295
ENSG00000143033 E021 151.2815941 0.0003015627 4.350850e-04 1.909413e-03 1 93114688 93114783 96 + 2.089 2.021 -0.229
ENSG00000143033 E022 160.2536205 0.0005478629 2.317026e-02 5.810144e-02 1 93114988 93115088 101 + 2.105 2.086 -0.061
ENSG00000143033 E023 190.7295049 0.0002223933 1.161495e-03 4.510620e-03 1 93115470 93115618 149 + 2.184 2.141 -0.142
ENSG00000143033 E024 118.0856654 0.0034799723 1.284683e-01 2.320296e-01 1 93118345 93118440 96 + 1.973 1.961 -0.039
ENSG00000143033 E025 103.1111409 0.0021380044 4.393511e-01 5.811055e-01 1 93119333 93119401 69 + 1.906 1.933 0.091
ENSG00000143033 E026 1.2671776 0.0221354502 6.696824e-01 7.763834e-01 1 93119402 93120274 873 + 0.301 0.241 -0.426
ENSG00000143033 E027 161.0968746 0.0002393334 1.518858e-01 2.642366e-01 1 93120549 93120672 124 + 2.100 2.115 0.050
ENSG00000143033 E028 1.6046638 0.1850262435 8.172954e-01 8.844634e-01 1 93120673 93120676 4 + 0.332 0.399 0.393
ENSG00000143033 E029 2.1883614 0.0069200056 7.677628e-01 8.499195e-01 1 93120793 93120798 6 + 0.410 0.509 0.506
ENSG00000143033 E030 3.1386899 0.0087936965 4.622057e-01 6.020633e-01 1 93120799 93120894 96 + 0.497 0.673 0.796
ENSG00000143033 E031 93.6973078 0.0003169962 5.905689e-01 7.134026e-01 1 93127232 93127238 7 + 1.861 1.902 0.137
ENSG00000143033 E032 132.1568187 0.0002699389 2.131865e-01 3.422992e-01 1 93127239 93127299 61 + 2.013 2.030 0.057
ENSG00000143033 E033 8.3223882 0.0228888603 3.209295e-02 7.603789e-02 1 93128795 93129277 483 + 0.918 0.599 -1.294
ENSG00000143033 E034 158.8951446 0.0021917189 5.592605e-01 6.873931e-01 1 93129278 93129448 171 + 2.077 2.165 0.296
ENSG00000143033 E035 159.3908763 0.0002755437 2.065679e-02 5.286298e-02 1 93133703 93133808 106 + 2.066 2.210 0.480
ENSG00000143033 E036 120.3627522 0.0002342462 2.558877e-01 3.928298e-01 1 93133928 93133980 53 + 1.955 2.065 0.368
ENSG00000143033 E037 184.9027508 0.0002055970 3.334161e-01 4.771426e-01 1 93134091 93134195 105 + 2.142 2.239 0.322
ENSG00000143033 E038 6.6546849 0.0027311461 4.530269e-01 5.938192e-01 1 93134196 93134459 264 + 0.798 0.737 -0.244
ENSG00000143033 E039 889.6722413 0.0091689079 1.382105e-07 1.367217e-06 1 93136670 93139079 2410 + 2.781 3.041 0.866