ENSG00000142949

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372407 ENSG00000142949 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRF protein_coding protein_coding 42.48709 52.20591 35.16636 2.950857 0.652299 -0.569883 9.368201 22.3330223 1.708177 1.5451992 0.8779728 -3.700874 0.19869167 0.43333333 0.04886667 -0.3844667 1.148676e-01 2.144597e-08 FALSE TRUE
ENST00000429895 ENSG00000142949 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRF protein_coding protein_coding 42.48709 52.20591 35.16636 2.950857 0.652299 -0.569883 1.255304 4.1818604 0.000000 1.9386659 0.0000000 -8.711447 0.02492500 0.07910000 0.00000000 -0.0791000 2.144597e-08 2.144597e-08 FALSE TRUE
ENST00000438120 ENSG00000142949 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRF protein_coding protein_coding 42.48709 52.20591 35.16636 2.950857 0.652299 -0.569883 24.518854 19.2632984 24.289616 3.8177609 0.1396557 0.334330 0.59697083 0.36436667 0.69106667 0.3267000 7.079263e-05 2.144597e-08 FALSE TRUE
MSTRG.1011.5 ENSG00000142949 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRF protein_coding   42.48709 52.20591 35.16636 2.950857 0.652299 -0.569883 1.318247 0.5703961 3.286106 0.5703961 0.6567177 2.505653 0.03242917 0.01033333 0.09313333 0.0828000 5.486260e-02 2.144597e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142949 E001 0.0000000       1 43525187 43525257 71 +      
ENSG00000142949 E002 0.0000000       1 43528562 43528656 95 +      
ENSG00000142949 E003 0.0000000       1 43528657 43528756 100 +      
ENSG00000142949 E004 1.7694164 0.0077693939 5.681320e-02 1.211400e-01 1 43530611 43530871 261 + 0.585 0.277 -1.671
ENSG00000142949 E005 2.3563361 0.0061007098 4.823748e-03 1.544048e-02 1 43530872 43530875 4 + 0.722 0.277 -2.256
ENSG00000142949 E006 2.6487578 0.0058303103 1.325674e-03 5.061365e-03 1 43530876 43530877 2 + 0.777 0.277 -2.479
ENSG00000142949 E007 3.0990377 0.0050950065 1.781641e-04 8.700931e-04 1 43530878 43530878 1 + 0.848 0.277 -2.759
ENSG00000142949 E008 3.0990377 0.0050950065 1.781641e-04 8.700931e-04 1 43530879 43530879 1 + 0.848 0.277 -2.759
ENSG00000142949 E009 4.9241172 0.0041596133 4.427984e-07 3.958420e-06 1 43530880 43530882 3 + 1.040 0.341 -3.064
ENSG00000142949 E010 10.2352236 0.0155966526 4.024346e-10 6.415891e-09 1 43530883 43530889 7 + 1.328 0.567 -2.913
ENSG00000142949 E011 19.1954859 0.0911021947 5.546489e-04 2.364406e-03 1 43530890 43530902 13 + 1.525 1.001 -1.846
ENSG00000142949 E012 29.2244854 0.0307826790 1.711919e-07 1.662402e-06 1 43530903 43530928 26 + 1.703 1.168 -1.853
ENSG00000142949 E013 111.6976928 0.0099667233 6.577988e-06 4.557584e-05 1 43530929 43531090 162 + 2.163 1.932 -0.774
ENSG00000142949 E014 75.6300852 0.0039647211 3.452565e-04 1.561008e-03 1 43538198 43538201 4 + 1.956 1.805 -0.505
ENSG00000142949 E015 136.6097051 0.0111637278 4.717287e-03 1.514345e-02 1 43538202 43538277 76 + 2.199 2.072 -0.427
ENSG00000142949 E016 122.3752477 0.0037399660 1.713512e-04 8.408748e-04 1 43545031 43545075 45 + 2.153 2.022 -0.440
ENSG00000142949 E017 165.9339790 0.0100322360 8.185880e-05 4.368055e-04 1 43545076 43545166 91 + 2.312 2.129 -0.612
ENSG00000142949 E018 211.3321657 0.0073840684 2.603513e-08 2.967855e-07 1 43553492 43553637 146 + 2.440 2.207 -0.776
ENSG00000142949 E019 217.4104237 0.0065914532 1.089408e-09 1.604362e-08 1 43553800 43553941 142 + 2.459 2.212 -0.823
ENSG00000142949 E020 230.1657127 0.0106228857 1.039094e-05 6.881057e-05 1 43569590 43569778 189 + 2.465 2.260 -0.684
ENSG00000142949 E021 0.0000000       1 43575910 43575927 18 +      
ENSG00000142949 E022 192.9218531 0.0088906183 3.473441e-05 2.032597e-04 1 43578810 43578920 111 + 2.376 2.197 -0.598
ENSG00000142949 E023 0.5138669 0.0206448903 4.367341e-01 5.787653e-01 1 43578921 43579175 255 + 0.233 0.113 -1.255
ENSG00000142949 E024 3.2397616 0.0078034628 2.792751e-01 4.189989e-01 1 43579176 43580078 903 + 0.496 0.688 0.859
ENSG00000142949 E025 0.1482932 0.0426941144 6.044778e-01   1 43582480 43582621 142 + 0.000 0.113 16.100
ENSG00000142949 E026 0.8878717 0.0180500325 8.576772e-01 9.121059e-01 1 43583082 43583093 12 + 0.233 0.277 0.330
ENSG00000142949 E027 346.2725654 0.0047907010 1.255834e-07 1.251789e-06 1 43588731 43589000 270 + 2.624 2.455 -0.561
ENSG00000142949 E028 175.4111746 0.0069932108 3.660875e-05 2.129519e-04 1 43590972 43591020 49 + 2.329 2.161 -0.558
ENSG00000142949 E029 136.3568994 0.0075719359 2.109558e-05 1.301281e-04 1 43591021 43591052 32 + 2.232 2.042 -0.636
ENSG00000142949 E030 322.2277202 0.0085116038 1.361115e-04 6.862517e-04 1 43591053 43591449 397 + 2.582 2.434 -0.492
ENSG00000142949 E031 155.2906055 0.0120343065 1.436827e-03 5.428849e-03 1 43591450 43591553 104 + 2.270 2.113 -0.522
ENSG00000142949 E032 203.1680418 0.0093813110 7.077754e-03 2.142872e-02 1 43591812 43591948 137 + 2.360 2.253 -0.356
ENSG00000142949 E033 105.1372261 0.0105689846 2.361023e-02 5.900897e-02 1 43592457 43592462 6 + 2.071 1.969 -0.343
ENSG00000142949 E034 195.8092062 0.0023842099 6.566181e-03 2.009894e-02 1 43592463 43592601 139 + 2.318 2.255 -0.210
ENSG00000142949 E035 276.7059402 0.0016058186 2.532898e-01 3.897955e-01 1 43597748 43598053 306 + 2.432 2.430 -0.006
ENSG00000142949 E036 7.8025557 0.0023592411 5.034297e-02 1.097733e-01 1 43598074 43598719 646 + 1.040 0.842 -0.742
ENSG00000142949 E037 161.1802867 0.0047008050 4.513407e-01 5.923061e-01 1 43598720 43598838 119 + 2.198 2.199 0.002
ENSG00000142949 E038 162.4278376 0.0013157334 1.269404e-04 6.453369e-04 1 43598839 43598913 75 + 2.258 2.161 -0.323
ENSG00000142949 E039 3.1928493 0.0607932304 7.593863e-01 8.437442e-01 1 43602071 43602097 27 + 0.623 0.602 -0.092
ENSG00000142949 E040 210.1238372 0.0010479853 6.210079e-07 5.392496e-06 1 43603416 43603527 112 + 2.378 2.263 -0.383
ENSG00000142949 E041 108.9284612 0.0003703650 1.074952e-06 8.861511e-06 1 43603528 43603533 6 + 2.107 1.966 -0.474
ENSG00000142949 E042 596.8690922 0.0008569712 6.998632e-06 4.820994e-05 1 43603611 43604189 579 + 2.800 2.741 -0.195
ENSG00000142949 E043 222.4723000 0.0003016013 4.842366e-01 6.222464e-01 1 43604903 43605000 98 + 2.332 2.343 0.035
ENSG00000142949 E044 327.1384328 0.0032417408 3.881314e-01 5.322536e-01 1 43605190 43605443 254 + 2.503 2.508 0.017
ENSG00000142949 E045 167.7905959 0.0020547076 7.839835e-03 2.337993e-02 1 43605529 43605581 53 + 2.251 2.188 -0.212
ENSG00000142949 E046 172.4347572 0.0002714001 3.289121e-04 1.496539e-03 1 43605582 43605622 41 + 2.267 2.195 -0.242
ENSG00000142949 E047 365.7915857 0.0005395408 5.043492e-02 1.099430e-01 1 43606240 43606458 219 + 2.560 2.547 -0.043
ENSG00000142949 E048 165.1208009 0.0002213435 2.765552e-01 4.160171e-01 1 43606814 43606816 3 + 2.210 2.207 -0.010
ENSG00000142949 E049 180.8953110 0.0002106667 3.677276e-01 5.120875e-01 1 43606817 43606830 14 + 2.246 2.249 0.011
ENSG00000142949 E050 368.6871843 0.0001591675 1.243413e-01 2.261812e-01 1 43606831 43606968 138 + 2.557 2.555 -0.005
ENSG00000142949 E051 337.2024587 0.0005610111 4.890499e-02 1.072103e-01 1 43609383 43609498 116 + 2.527 2.512 -0.051
ENSG00000142949 E052 2.0119530 0.2717546805 3.155208e-01 4.582861e-01 1 43612768 43612800 33 + 0.587 0.348 -1.218
ENSG00000142949 E053 2.6132808 0.0059273144 1.431442e-01 2.523049e-01 1 43613140 43613617 478 + 0.659 0.445 -0.993
ENSG00000142949 E054 341.5724003 0.0002054865 3.625403e-03 1.208287e-02 1 43613618 43613715 98 + 2.541 2.510 -0.102
ENSG00000142949 E055 417.3799233 0.0003914535 2.322236e-01 3.650842e-01 1 43617445 43617568 124 + 2.608 2.613 0.017
ENSG00000142949 E056 489.1706606 0.0009125461 8.629403e-01 9.156293e-01 1 43617736 43617911 176 + 2.664 2.690 0.087
ENSG00000142949 E057 357.8527224 0.0001666059 4.944952e-02 1.081813e-01 1 43618630 43618749 120 + 2.502 2.569 0.223
ENSG00000142949 E058 382.5542228 0.0001347701 4.306510e-04 1.892326e-03 1 43619048 43619202 155 + 2.512 2.608 0.317
ENSG00000142949 E059 576.1279282 0.0001683839 5.025564e-06 3.576148e-05 1 43619288 43619573 286 + 2.686 2.788 0.338
ENSG00000142949 E060 494.4185225 0.0004294662 1.189809e-03 4.606792e-03 1 43619680 43619858 179 + 2.627 2.717 0.300
ENSG00000142949 E061 430.4315970 0.0002795426 3.586538e-06 2.639495e-05 1 43620095 43620221 127 + 2.551 2.668 0.388
ENSG00000142949 E062 6.4849013 0.0026272839 2.886681e-01 4.292822e-01 1 43620222 43620453 232 + 0.928 0.823 -0.402
ENSG00000142949 E063 452.6235391 0.0036306774 1.928634e-02 4.995746e-02 1 43620454 43620579 126 + 2.580 2.690 0.364
ENSG00000142949 E064 518.4902144 0.0023177834 4.704308e-04 2.046940e-03 1 43620838 43620992 155 + 2.627 2.755 0.427
ENSG00000142949 E065 418.3334428 0.0007544838 1.064368e-18 5.865074e-17 1 43621097 43621232 136 + 2.465 2.692 0.756
ENSG00000142949 E066 2730.0740969 0.0074937261 1.603164e-12 3.795958e-11 1 43621935 43623666 1732 + 3.235 3.526 0.966