ENSG00000142892

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370812 ENSG00000142892 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGK protein_coding protein_coding 55.59457 7.234127 93.25536 0.4485019 0.6805284 3.686458 12.812381 2.8797477 21.48487 0.7340366 0.8710069 2.894977 0.2928750 0.3892333 0.2303333 -0.1589000 1.792573e-01 7.236176e-23 FALSE TRUE
ENST00000487906 ENSG00000142892 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGK protein_coding nonsense_mediated_decay 55.59457 7.234127 93.25536 0.4485019 0.6805284 3.686458 14.590010 0.0000000 21.19113 0.0000000 1.9895025 11.049926 0.1798708 0.0000000 0.2273000 0.2273000 7.236176e-23 7.236176e-23 FALSE TRUE
MSTRG.1438.1 ENSG00000142892 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGK protein_coding   55.59457 7.234127 93.25536 0.4485019 0.6805284 3.686458 5.582048 2.8261995 12.52728 0.5415076 0.4354775 2.144194 0.2130500 0.3905000 0.1344000 -0.2561000 1.264003e-03 7.236176e-23 TRUE TRUE
MSTRG.1438.6 ENSG00000142892 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGK protein_coding   55.59457 7.234127 93.25536 0.4485019 0.6805284 3.686458 19.482107 0.8570948 32.57005 0.4573899 1.5250886 5.231655 0.2560875 0.1267000 0.3491333 0.2224333 4.450585e-01 7.236176e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142892 E001 0.5827671 0.1380414994 1.000000e+00 1.000000e+00 1 77077005 77077063 59 - 0.164 0.001 -8.312
ENSG00000142892 E002 0.9921577 0.0127452365 1.552161e-03 5.805115e-03 1 77088989 77088989 1 - 0.090 0.669 3.993
ENSG00000142892 E003 664.1825421 0.0135633281 1.312608e-01 2.359004e-01 1 77088990 77091287 2298 - 2.640 2.737 0.323
ENSG00000142892 E004 75.5046121 0.0004172946 6.541222e-01 7.643953e-01 1 77091288 77091313 26 - 1.716 1.756 0.135
ENSG00000142892 E005 397.7930856 0.0001552416 1.009084e-21 7.771057e-20 1 77091314 77092201 888 - 2.397 2.629 0.774
ENSG00000142892 E006 310.0967161 0.0004626463 4.876992e-02 1.069752e-01 1 77092202 77092490 289 - 2.317 2.387 0.236
ENSG00000142892 E007 275.6022423 0.0002058531 1.784093e-02 4.679568e-02 1 77122275 77122359 85 - 2.284 2.218 -0.218
ENSG00000142892 E008 3.1044369 0.0049462436 8.392406e-01 8.995465e-01 1 77153536 77154448 913 - 0.488 0.453 -0.176
ENSG00000142892 E009 248.5047606 0.0001933770 4.627874e-04 2.017296e-03 1 77154449 77154493 45 - 2.243 2.130 -0.376
ENSG00000142892 E010 329.6241887 0.0003099960 4.686646e-02 1.035926e-01 1 77154494 77154621 128 - 2.357 2.309 -0.161
ENSG00000142892 E011 0.4375944 0.0273168808 1.000000e+00 1.000000e+00 1 77160488 77160568 81 - 0.129 0.001 -7.865
ENSG00000142892 E012 297.7395848 0.0001600540 4.513416e-01 5.923061e-01 1 77161295 77161405 111 - 2.310 2.299 -0.034
ENSG00000142892 E013 270.5995063 0.0001940514 7.945237e-01 8.687329e-01 1 77161594 77161711 118 - 2.264 2.285 0.070
ENSG00000142892 E014 227.1257879 0.0003179439 1.522832e-01 2.647943e-01 1 77163846 77163942 97 - 2.196 2.156 -0.132
ENSG00000142892 E015 244.5165765 0.0001910022 3.678432e-02 8.505546e-02 1 77166719 77166830 112 - 2.230 2.170 -0.201
ENSG00000142892 E016 298.7500506 0.0001573690 1.254339e-04 6.386204e-04 1 77169260 77169395 136 - 2.322 2.211 -0.372
ENSG00000142892 E017 311.5701489 0.0018588105 2.592032e-01 3.965828e-01 1 77206640 77206731 92 - 2.331 2.298 -0.109
ENSG00000142892 E018 268.3614995 0.0032929886 9.712581e-02 1.860842e-01 1 77210436 77210489 54 - 2.271 2.207 -0.214
ENSG00000142892 E019 265.9295275 0.0037430247 3.588736e-03 1.197870e-02 1 77219310 77219430 121 - 2.273 2.146 -0.425