ENSG00000142875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370689 ENSG00000142875 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKACB protein_coding protein_coding 7.105163 2.283068 12.27751 0.3336439 0.5736145 2.421842 5.1188307 1.1161600 9.692383 0.2200585 0.4803282 3.106927 0.65161250 0.5354000 0.7892000 0.2538000 4.219674e-01 9.100559e-07 FALSE TRUE
ENST00000432111 ENSG00000142875 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKACB protein_coding protein_coding 7.105163 2.283068 12.27751 0.3336439 0.5736145 2.421842 0.7833719 0.0000000 1.563411 0.0000000 0.3059497 7.297752 0.06188333 0.0000000 0.1256333 0.1256333 9.100559e-07 9.100559e-07 FALSE FALSE
ENST00000610457 ENSG00000142875 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKACB protein_coding protein_coding 7.105163 2.283068 12.27751 0.3336439 0.5736145 2.421842 0.2118447 0.5106564 0.000000 0.5106564 0.0000000 -5.702260 0.08498750 0.1775000 0.0000000 -0.1775000 5.152702e-01 9.100559e-07 FALSE TRUE
ENST00000610703 ENSG00000142875 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKACB protein_coding protein_coding 7.105163 2.283068 12.27751 0.3336439 0.5736145 2.421842 0.5621771 0.3967179 0.000000 0.3967179 0.0000000 -5.345957 0.13086667 0.1763667 0.0000000 -0.1763667 5.850299e-01 9.100559e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142875 E001 10.5433525 0.0056957430 6.074567e-01 7.274298e-01 1 84078062 84078143 82 + 0.982 0.924 -0.216
ENSG00000142875 E002 41.6267138 0.0005715126 1.348933e-02 3.705468e-02 1 84078144 84078371 228 + 1.555 1.379 -0.605
ENSG00000142875 E003 0.0000000       1 84144271 84144321 51 +      
ENSG00000142875 E004 0.5975289 0.0335266925 5.740416e-01 6.999045e-01 1 84144322 84144548 227 + 0.197 0.000 -11.412
ENSG00000142875 E005 0.0000000       1 84157335 84157405 71 +      
ENSG00000142875 E006 0.0000000       1 84164317 84164322 6 +      
ENSG00000142875 E007 0.0000000       1 84164323 84164381 59 +      
ENSG00000142875 E008 0.0000000       1 84164382 84164393 12 +      
ENSG00000142875 E009 0.0000000       1 84164394 84164422 29 +      
ENSG00000142875 E010 0.0000000       1 84164681 84164694 14 +      
ENSG00000142875 E011 0.0000000       1 84164695 84164903 209 +      
ENSG00000142875 E012 0.0000000       1 84164904 84164911 8 +      
ENSG00000142875 E013 0.0000000       1 84164912 84164965 54 +      
ENSG00000142875 E014 0.0000000       1 84164966 84165013 48 +      
ENSG00000142875 E015 0.1472490 0.0453181237 1.000000e+00   1 84173329 84173352 24 + 0.058 0.000 -9.354
ENSG00000142875 E016 0.1451727 0.0436536137 1.000000e+00   1 84175033 84175056 24 + 0.058 0.000 -9.366
ENSG00000142875 E017 0.2987644 0.0276389487 1.000000e+00   1 84175799 84175807 9 + 0.109 0.000 -10.502
ENSG00000142875 E018 0.2987644 0.0276389487 1.000000e+00   1 84178835 84179176 342 + 0.109 0.000 -10.502
ENSG00000142875 E019 31.0905770 0.0006642184 2.614335e-05 1.577670e-04 1 84179177 84179238 62 + 1.456 1.056 -1.413
ENSG00000142875 E020 0.0000000       1 84181660 84181728 69 +      
ENSG00000142875 E021 49.8483176 0.0007965367 8.600957e-05 4.563195e-04 1 84182200 84182328 129 + 1.644 1.366 -0.955
ENSG00000142875 E022 45.6693280 0.0004808497 2.447698e-04 1.153398e-03 1 84184037 84184135 99 + 1.604 1.337 -0.919
ENSG00000142875 E023 43.6332086 0.0005513149 1.643143e-03 6.098724e-03 1 84185100 84185182 83 + 1.580 1.352 -0.787
ENSG00000142875 E024 56.9222063 0.0003972116 8.353870e-03 2.467593e-02 1 84196616 84196742 127 + 1.684 1.526 -0.540
ENSG00000142875 E025 51.4440551 0.0004610623 8.692648e-03 2.551827e-02 1 84197729 84197824 96 + 1.643 1.475 -0.572
ENSG00000142875 E026 58.5389744 0.0003937570 2.488605e-02 6.163906e-02 1 84202683 84202805 123 + 1.692 1.563 -0.440
ENSG00000142875 E027 2.5893329 0.0059952214 1.133113e-02 3.195607e-02 1 84204479 84204481 3 + 0.359 0.791 2.009
ENSG00000142875 E028 11.3667801 0.0018395442 9.508328e-09 1.177492e-07 1 84204482 84205439 958 + 0.818 1.405 2.129
ENSG00000142875 E029 61.9484916 0.0004612322 9.404271e-06 6.289667e-05 1 84214153 84214317 165 + 1.734 1.453 -0.958
ENSG00000142875 E030 489.4840388 0.0003471892 7.646416e-25 8.272933e-23 1 84235180 84238498 3319 + 2.555 2.704 0.498