ENSG00000142864

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370990 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding protein_coding 609.3935 426.1103 862.121 33.67952 39.36174 1.016646 30.51674 33.37336 18.30533 1.787988 3.922391 -0.8660774 0.06277500 0.0789000 0.02170000 -0.05720000 7.337473e-05 1.65216e-69 FALSE TRUE
ENST00000370995 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding protein_coding 609.3935 426.1103 862.121 33.67952 39.36174 1.016646 109.65281 72.13970 183.65774 9.746769 8.368930 1.3480330 0.16719583 0.1680000 0.21303333 0.04503333 2.884254e-02 1.65216e-69 FALSE TRUE
ENST00000484880 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding processed_transcript 609.3935 426.1103 862.121 33.67952 39.36174 1.016646 178.18186 110.14868 263.27502 6.988871 10.649187 1.2570422 0.28462917 0.2592000 0.30553333 0.04633333 5.336209e-04 1.65216e-69 FALSE TRUE
ENST00000490406 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding processed_transcript 609.3935 426.1103 862.121 33.67952 39.36174 1.016646 25.41191 0.00000 59.42168 0.000000 7.732777 12.5370163 0.03008333 0.0000000 0.06846667 0.06846667 1.652160e-69 1.65216e-69   FALSE
ENST00000493607 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding processed_transcript 609.3935 426.1103 862.121 33.67952 39.36174 1.016646 131.38256 123.59225 148.69254 11.761897 17.702206 0.2667243 0.23208333 0.2894333 0.17130000 -0.11813333 2.691001e-05 1.65216e-69 FALSE FALSE
MSTRG.1374.12 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding   609.3935 426.1103 862.121 33.67952 39.36174 1.016646 41.74231 25.16269 61.34976 1.608267 3.349283 1.2854332 0.06954167 0.0594000 0.07180000 0.01240000 5.290400e-01 1.65216e-69 FALSE FALSE
MSTRG.1374.5 ENSG00000142864 HEK293_OSMI2_2hA HEK293_TMG_2hB SERBP1 protein_coding   609.3935 426.1103 862.121 33.67952 39.36174 1.016646 66.86898 48.12808 87.84054 1.901311 4.849339 0.8678727 0.11350000 0.1136667 0.10230000 -0.01136667 6.667639e-01 1.65216e-69 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142864 E001 1400.9263564 8.148107e-03 1.562204e-10 2.666741e-09 1 67407810 67411037 3228 - 3.249 2.940 -1.025
ENSG00000142864 E002 7006.1473454 3.545673e-03 9.090722e-08 9.298185e-07 1 67411038 67412866 1829 - 3.905 3.737 -0.559
ENSG00000142864 E003 4422.9456628 6.470829e-04 1.658093e-18 8.883505e-17 1 67412867 67413215 349 - 3.604 3.690 0.287
ENSG00000142864 E004 2393.7276340 1.091056e-03 5.467922e-13 1.398517e-11 1 67413216 67413258 43 - 3.331 3.431 0.335
ENSG00000142864 E005 1753.5214909 5.880341e-03 5.488313e-04 2.342558e-03 1 67413259 67413263 5 - 3.190 3.300 0.364
ENSG00000142864 E006 3860.5985165 1.248664e-04 1.114269e-53 8.511890e-51 1 67415166 67415272 107 - 3.543 3.636 0.309
ENSG00000142864 E007 3173.0392677 6.551085e-05 9.624314e-67 1.266179e-63 1 67415273 67415339 67 - 3.455 3.556 0.335
ENSG00000142864 E008 3.9359075 1.306479e-02 1.427740e-01 2.518093e-01 1 67417050 67417166 117 - 0.786 0.542 -1.038
ENSG00000142864 E009 9.8067314 6.836290e-03 9.258262e-01 9.572918e-01 1 67419765 67420008 244 - 1.039 1.006 -0.121
ENSG00000142864 E010 5854.2759697 1.742805e-04 3.117875e-13 8.256529e-12 1 67420009 67420167 159 - 3.753 3.780 0.088
ENSG00000142864 E011 3290.9121551 2.929283e-04 1.603195e-01 2.755634e-01 1 67420168 67420186 19 - 3.532 3.490 -0.139
ENSG00000142864 E012 18.2043070 9.738903e-03 3.266268e-05 1.925878e-04 1 67420187 67420565 379 - 1.423 0.985 -1.558
ENSG00000142864 E013 4605.6578288 5.569426e-04 6.355774e-01 7.498520e-01 1 67424200 67424277 78 - 3.670 3.645 -0.083
ENSG00000142864 E014 555.9231011 4.769574e-04 6.375681e-01 7.514284e-01 1 67424278 67424284 7 - 2.757 2.723 -0.114
ENSG00000142864 E015 776.9983827 1.677409e-04 8.474642e-02 1.669958e-01 1 67424285 67424322 38 - 2.909 2.860 -0.161
ENSG00000142864 E016 10.9392169 2.184354e-03 5.199074e-06 3.685496e-05 1 67424323 67424414 92 - 1.232 0.676 -2.104
ENSG00000142864 E017 4281.7474912 5.603430e-04 2.984764e-02 7.166361e-02 1 67424888 67424959 72 - 3.651 3.594 -0.190
ENSG00000142864 E018 1306.1522056 7.820693e-05 8.870071e-09 1.104007e-07 1 67424960 67424977 18 - 3.149 3.063 -0.284
ENSG00000142864 E019 4914.3084299 8.611326e-05 1.620993e-15 5.965273e-14 1 67425083 67425223 141 - 3.721 3.643 -0.257
ENSG00000142864 E020 4431.3249169 8.611364e-04 2.334443e-04 1.105965e-03 1 67426135 67426285 151 - 3.677 3.592 -0.280
ENSG00000142864 E021 0.8136755 1.457190e-02 8.861443e-01 9.311935e-01 1 67429436 67429657 222 - 0.247 0.263 0.119
ENSG00000142864 E022 4810.1400551 4.133010e-03 1.506128e-01 2.625113e-01 1 67429988 67431530 1543 - 3.709 3.631 -0.261