ENSG00000142856

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271002 ENSG00000142856 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB3BP protein_coding protein_coding 43.96804 17.69607 74.30387 3.132483 2.645133 2.069387 18.668203 9.3792078 27.736287 1.33345250 0.9093540 1.563219 0.42454583 0.53690000 0.37340000 -0.163500000 0.0009165889 1.236945e-06 FALSE TRUE
ENST00000463803 ENSG00000142856 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB3BP protein_coding processed_transcript 43.96804 17.69607 74.30387 3.132483 2.645133 2.069387 1.692933 0.4946094 1.958112 0.09182694 0.1589895 1.963573 0.05350000 0.03043333 0.02640000 -0.004033333 0.9698522377 1.236945e-06   FALSE
ENST00000476508 ENSG00000142856 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB3BP protein_coding processed_transcript 43.96804 17.69607 74.30387 3.132483 2.645133 2.069387 4.107233 1.0970994 6.544088 0.58481849 0.5731673 2.565610 0.08382083 0.05703333 0.08790000 0.030866667 0.7160919051 1.236945e-06 FALSE TRUE
ENST00000489099 ENSG00000142856 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB3BP protein_coding nonsense_mediated_decay 43.96804 17.69607 74.30387 3.132483 2.645133 2.069387 8.475327 1.9245998 19.989189 0.79585867 1.2354581 3.369834 0.17070833 0.10143333 0.26873333 0.167300000 0.0161726522 1.236945e-06 TRUE TRUE
MSTRG.1337.1 ENSG00000142856 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB3BP protein_coding   43.96804 17.69607 74.30387 3.132483 2.645133 2.069387 2.246786 1.1234160 3.805584 0.56560207 0.2728518 1.751226 0.05713333 0.06053333 0.05113333 -0.009400000 0.9224140381 1.236945e-06 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142856 E001 8.2643686 0.0025544806 4.816472e-01 6.198356e-01 1 63440667 63440689 23 - 0.895 0.985 0.336
ENSG00000142856 E002 9.2190642 0.0017871220 3.791439e-01 5.234262e-01 1 63440690 63440723 34 - 0.931 1.037 0.392
ENSG00000142856 E003 9.7425081 0.0028903080 2.181518e-01 3.481882e-01 1 63440724 63440769 46 - 0.940 1.084 0.529
ENSG00000142856 E004 12.9010980 0.0160514443 8.845240e-01 9.301767e-01 1 63440770 63440771 2 - 1.096 1.081 -0.053
ENSG00000142856 E005 16.3814125 0.0075463282 5.912024e-01 7.139948e-01 1 63440772 63440772 1 - 1.172 1.231 0.208
ENSG00000142856 E006 45.8146880 0.0039619176 3.289147e-05 1.937559e-04 1 63440773 63440799 27 - 1.535 1.796 0.887
ENSG00000142856 E007 355.7480485 0.0003742222 3.514117e-14 1.066377e-12 1 63440800 63441103 304 - 2.450 2.612 0.541
ENSG00000142856 E008 25.7717830 0.0509315063 9.259443e-01 9.573706e-01 1 63442510 63443195 686 - 1.364 1.364 0.002
ENSG00000142856 E009 5.9136243 0.0430612262 1.239816e-02 3.449289e-02 1 63446558 63446805 248 - 0.866 0.351 -2.355
ENSG00000142856 E010 217.6359869 0.0027281766 6.892571e-01 7.911546e-01 1 63446806 63446856 51 - 2.278 2.298 0.067
ENSG00000142856 E011 9.7267945 0.0017187956 2.205874e-01 3.511231e-01 1 63446857 63447060 204 - 1.011 0.856 -0.581
ENSG00000142856 E012 80.2811599 0.0003564984 6.293882e-05 3.458413e-04 1 63447565 63447614 50 - 1.894 1.697 -0.665
ENSG00000142856 E013 9.1087553 0.0097271301 1.182319e-01 2.173912e-01 1 63447615 63447789 175 - 0.996 0.774 -0.849
ENSG00000142856 E014 9.4479886 0.0018963139 4.352522e-01 5.774882e-01 1 63449303 63449495 193 - 0.988 0.892 -0.361
ENSG00000142856 E015 45.1168103 0.0005091715 4.926969e-02 1.078681e-01 1 63449496 63449815 320 - 1.576 1.692 0.396
ENSG00000142856 E016 11.9941250 0.0029358059 1.746728e-04 8.556151e-04 1 63451725 63452064 340 - 1.141 0.612 -2.054
ENSG00000142856 E017 3.1074462 0.0183385530 3.324882e-03 1.121997e-02 1 63453615 63453775 161 - 0.662 0.000 -14.482
ENSG00000142856 E018 4.3587162 0.0072312872 3.140696e-02 7.469844e-02 1 63453776 63453831 56 - 0.750 0.350 -1.902
ENSG00000142856 E019 4.7975702 0.0032911108 2.443002e-03 8.591254e-03 1 63453832 63453917 86 - 0.800 0.209 -3.101
ENSG00000142856 E020 244.3836454 0.0001661921 9.542851e-01 9.753517e-01 1 63453918 63453974 57 - 2.332 2.336 0.013
ENSG00000142856 E021 314.6939328 0.0001793010 4.969061e-01 6.334698e-01 1 63454380 63454473 94 - 2.437 2.454 0.058
ENSG00000142856 E022 284.6553315 0.0001842046 7.127491e-01 8.093795e-01 1 63454890 63454968 79 - 2.395 2.405 0.035
ENSG00000142856 E023 10.3219805 0.0447478702 4.964457e-01 6.331031e-01 1 63457134 63457464 331 - 1.025 0.895 -0.484
ENSG00000142856 E024 9.7491952 0.0308989147 1.070452e-02 3.046418e-02 1 63457465 63457683 219 - 1.051 0.612 -1.728
ENSG00000142856 E025 16.2563125 0.0048712530 8.989414e-07 7.537477e-06 1 63457684 63458373 690 - 1.278 0.611 -2.542
ENSG00000142856 E026 327.7458759 0.0001409976 8.471452e-03 2.496470e-02 1 63478764 63478833 70 - 2.473 2.415 -0.193
ENSG00000142856 E027 259.9770191 0.0001656902 4.688448e-03 1.506466e-02 1 63490083 63490102 20 - 2.375 2.304 -0.238
ENSG00000142856 E028 356.0958505 0.0001549710 1.628957e-02 4.336477e-02 1 63490103 63490218 116 - 2.506 2.455 -0.169
ENSG00000142856 E029 250.6287009 0.0012278651 5.263118e-01 6.595591e-01 1 63508528 63508570 43 - 2.346 2.325 -0.071
ENSG00000142856 E030 9.6987218 0.0190422811 3.079171e-02 7.351013e-02 1 63510065 63510181 117 - 0.895 1.163 0.984
ENSG00000142856 E031 219.6861985 0.0016837011 7.514814e-01 8.379147e-01 1 63523129 63523502 374 - 2.282 2.289 0.023
ENSG00000142856 E032 0.2214452 0.0590168141 1.189448e-01   1 63527879 63527970 92 - 0.000 0.210 11.658
ENSG00000142856 E033 0.2214452 0.0590168141 1.189448e-01   1 63529131 63529186 56 - 0.000 0.210 11.658
ENSG00000142856 E034 0.3686942 0.0402292499 3.432563e-01 4.873107e-01 1 63593525 63593721 197 - 0.069 0.210 1.857