ENSG00000142794

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318220 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding nonsense_mediated_decay 9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.9347152 1.0511227 0.4287509 0.18429382 0.4287509 -1.2741174 0.10577083 0.119100000 0.05110000 -0.06800000 0.219091706 0.000313739 FALSE TRUE
ENST00000318249 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding protein_coding 9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.8261024 1.2728319 0.6251276 0.53076836 0.1625459 -1.0142138 0.08986250 0.129066667 0.07426667 -0.05480000 0.655817042 0.000313739 FALSE TRUE
ENST00000454000 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding protein_coding 9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.8054218 0.8908840 0.7394601 0.22714515 0.2312730 -0.2654897 0.08975833 0.103566667 0.08723333 -0.01633333 0.906766951 0.000313739 FALSE TRUE
ENST00000469876 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding processed_transcript 9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 1.1542049 2.3988649 0.3897965 0.75083399 0.2654597 -2.5910156 0.11747917 0.254000000 0.04670000 -0.20730000 0.117656492 0.000313739 FALSE TRUE
ENST00000478653 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding processed_transcript 9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.9045164 0.5827749 1.2221493 0.03858534 0.1076013 1.0556209 0.10056667 0.067333333 0.14476667 0.07743333 0.005431160 0.000313739   FALSE
ENST00000619554 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding protein_coding 9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 1.1133663 1.1749163 0.2651126 0.61290319 0.2651126 -2.1066912 0.11775417 0.141533333 0.03160000 -0.10993333 0.509161899 0.000313739 FALSE TRUE
MSTRG.495.1 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding   9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 1.3502772 0.1604022 2.5755327 0.08020364 0.4055880 3.9234460 0.14958333 0.020300000 0.30510000 0.28480000 0.000313739 0.000313739 FALSE TRUE
MSTRG.495.11 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding   9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.5193260 0.1069635 0.8070315 0.10696351 0.4043583 2.8043332 0.05402500 0.009833333 0.09630000 0.08646667 0.123885161 0.000313739 FALSE TRUE
MSTRG.495.12 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding   9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.1149052 0.0000000 0.5235352 0.00000000 0.5235352 5.7375115 0.01295417 0.000000000 0.06083333 0.06083333 0.836719086 0.000313739 FALSE TRUE
MSTRG.495.4 ENSG00000142794 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF3 protein_coding   9.166995 9.045321 8.443629 1.429147 0.08385527 -0.09919505 0.6542999 1.2068750 0.2539357 0.35657783 0.2539357 -2.2049224 0.07355000 0.135833333 0.03026667 -0.10556667 0.142144205 0.000313739 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142794 E001 1.7661941 0.0080650954 3.329539e-01 4.766257e-01 1 21440106 21440127 22 + 0.515 0.363 -0.797
ENSG00000142794 E002 1.8350943 0.0090292921 6.905749e-02 1.418136e-01 1 21440128 21440130 3 + 0.593 0.297 -1.575
ENSG00000142794 E003 1.8350943 0.0090292921 6.905749e-02 1.418136e-01 1 21440131 21440134 4 + 0.593 0.297 -1.575
ENSG00000142794 E004 2.1275160 0.0101219377 2.524176e-02 6.236979e-02 1 21440135 21440136 2 + 0.660 0.297 -1.865
ENSG00000142794 E005 2.1275160 0.0101219377 2.524176e-02 6.236979e-02 1 21440137 21440137 1 + 0.660 0.297 -1.865
ENSG00000142794 E006 2.7207785 0.0058444012 2.680930e-03 9.316422e-03 1 21440138 21440145 8 + 0.768 0.297 -2.312
ENSG00000142794 E007 9.4273274 0.0031176519 2.015781e-02 5.181525e-02 1 21440146 21440163 18 + 1.125 0.895 -0.845
ENSG00000142794 E008 24.0845827 0.0112621442 3.566413e-01 5.010281e-01 1 21440164 21440237 74 + 1.430 1.372 -0.203
ENSG00000142794 E009 34.4606058 0.0020797950 5.455829e-02 1.172150e-01 1 21440238 21440348 111 + 1.601 1.505 -0.328
ENSG00000142794 E010 0.0000000       1 21440349 21440378 30 +      
ENSG00000142794 E011 0.0000000       1 21440797 21440914 118 +      
ENSG00000142794 E012 0.0000000       1 21442240 21442358 119 +      
ENSG00000142794 E013 0.0000000       1 21444944 21444947 4 +      
ENSG00000142794 E014 30.6653542 0.0006827533 1.105570e-01 2.063476e-01 1 21444948 21444991 44 + 1.541 1.464 -0.265
ENSG00000142794 E015 66.8497069 0.0004267722 1.574660e-02 4.216462e-02 1 21444992 21445219 228 + 1.875 1.795 -0.269
ENSG00000142794 E016 1.3922013 0.0981126089 7.381412e-01 8.281006e-01 1 21446037 21446482 446 + 0.418 0.361 -0.322
ENSG00000142794 E017 0.6060617 0.8849391980 3.165616e-01 4.593493e-01 1 21449791 21449858 68 + 0.364 0.000 -11.622
ENSG00000142794 E018 0.3030308 0.4023726397 2.981916e-01   1 21449859 21449888 30 + 0.218 0.000 -10.988
ENSG00000142794 E019 0.3299976 0.0274424043 2.115365e-01   1 21451767 21451909 143 + 0.000 0.218 11.251
ENSG00000142794 E020 18.9648330 0.0037958034 1.347839e-02 3.703107e-02 1 21453373 21454306 934 + 1.392 1.213 -0.629
ENSG00000142794 E021 0.2966881 0.0271085740 1.955574e-01   1 21459749 21460000 252 + 0.217 0.000 -12.180
ENSG00000142794 E022 6.4086062 0.0394727543 4.808130e-02 1.057730e-01 1 21465735 21465738 4 + 1.003 0.719 -1.100
ENSG00000142794 E023 14.4023587 0.0013000243 3.631205e-03 1.210068e-02 1 21465739 21465817 79 + 1.304 1.071 -0.829
ENSG00000142794 E024 20.8028195 0.0009041959 2.454619e-02 6.094230e-02 1 21466087 21466156 70 + 1.415 1.270 -0.503
ENSG00000142794 E025 18.4299018 0.0011822423 2.834666e-04 1.312587e-03 1 21466996 21467181 186 + 1.415 1.148 -0.935
ENSG00000142794 E026 30.3010980 0.0008991960 1.827652e-04 8.897438e-04 1 21467182 21467309 128 + 1.598 1.384 -0.735
ENSG00000142794 E027 3.2600283 0.0047438279 3.865780e-02 8.854878e-02 1 21468155 21468334 180 + 0.768 0.471 -1.313
ENSG00000142794 E028 27.7770081 0.0227904959 3.741174e-03 1.241403e-02 1 21468441 21468549 109 + 1.584 1.308 -0.950
ENSG00000142794 E029 20.5417898 0.0273348457 3.745190e-03 1.242508e-02 1 21468550 21468585 36 + 1.471 1.160 -1.089
ENSG00000142794 E030 53.0598088 0.0056883148 1.968456e-01 3.222938e-01 1 21468688 21468897 210 + 1.764 1.706 -0.198
ENSG00000142794 E031 40.4988708 0.0005688366 7.702324e-01 8.516197e-01 1 21470632 21470734 103 + 1.618 1.624 0.020
ENSG00000142794 E032 57.8621826 0.0004523350 1.318183e-02 3.633590e-02 1 21471569 21471783 215 + 1.821 1.731 -0.302
ENSG00000142794 E033 42.4363899 0.0006847782 7.009397e-01 8.002972e-01 1 21472843 21472915 73 + 1.645 1.647 0.008
ENSG00000142794 E034 3.1258129 0.0098303463 7.483740e-01 8.356401e-01 1 21473377 21473379 3 + 0.593 0.661 0.295
ENSG00000142794 E035 25.1481266 0.0216777484 3.836128e-01 5.278151e-01 1 21473380 21473394 15 + 1.356 1.475 0.410
ENSG00000142794 E036 65.8113620 0.0059039436 8.902101e-01 9.338548e-01 1 21473395 21473585 191 + 1.814 1.844 0.100
ENSG00000142794 E037 42.1140556 0.0059634424 2.168664e-01 3.466305e-01 1 21474900 21474951 52 + 1.583 1.682 0.336
ENSG00000142794 E038 1.9466759 0.0101974778 2.242318e-02 5.655711e-02 1 21478069 21478143 75 + 0.217 0.629 2.328
ENSG00000142794 E039 40.0855964 0.0011326593 3.049302e-01 4.469635e-01 1 21478144 21478196 53 + 1.572 1.651 0.267
ENSG00000142794 E040 29.4093439 0.0047290743 1.800984e-01 3.012990e-01 1 21478197 21478227 31 + 1.420 1.534 0.393
ENSG00000142794 E041 37.5999792 0.0009733762 4.377915e-02 9.798715e-02 1 21478228 21478307 80 + 1.507 1.644 0.469
ENSG00000142794 E042 38.7759042 0.0044607442 5.453991e-02 1.171862e-01 1 21479349 21479400 52 + 1.516 1.657 0.482
ENSG00000142794 E043 57.2543071 0.0004151531 6.763578e-02 1.394259e-01 1 21480051 21480223 173 + 1.707 1.813 0.357
ENSG00000142794 E044 39.5088781 0.0006051180 5.064676e-01 6.421285e-01 1 21480930 21480981 52 + 1.618 1.604 -0.050
ENSG00000142794 E045 67.8496142 0.0003989300 6.112134e-01 7.303761e-01 1 21481597 21481769 173 + 1.819 1.862 0.146
ENSG00000142794 E046 55.2099449 0.0004549981 1.116081e-02 3.155136e-02 1 21482484 21482535 52 + 1.670 1.811 0.477
ENSG00000142794 E047 275.8319949 0.0054586998 7.439253e-07 6.353835e-06 1 21483143 21485005 1863 + 2.329 2.521 0.643