ENSG00000142784

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319394 ENSG00000142784 HEK293_OSMI2_2hA HEK293_TMG_2hB WDTC1 protein_coding protein_coding 26.24959 38.33835 19.82507 2.741113 0.2040931 -0.9511105 2.261256 4.759107 0.8041536 0.8569423 0.1017898 -2.550346 0.07546250 0.12226667 0.04066667 -0.08160000 7.717109e-05 9.503677e-06 FALSE TRUE
MSTRG.636.5 ENSG00000142784 HEK293_OSMI2_2hA HEK293_TMG_2hB WDTC1 protein_coding   26.24959 38.33835 19.82507 2.741113 0.2040931 -0.9511105 2.073989 1.154958 3.4874765 0.4555491 0.3149253 1.586036 0.09638333 0.02913333 0.17596667 0.14683333 9.503677e-06 9.503677e-06 TRUE TRUE
MSTRG.636.8 ENSG00000142784 HEK293_OSMI2_2hA HEK293_TMG_2hB WDTC1 protein_coding   26.24959 38.33835 19.82507 2.741113 0.2040931 -0.9511105 19.089671 29.026947 14.1059681 1.7476895 0.5116470 -1.040562 0.71846250 0.75863333 0.71126667 -0.04736667 4.288964e-01 9.503677e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142784 E001 0.4481018 0.1913731674 9.052471e-01 9.436745e-01 1 27234415 27234468 54 + 0.169 0.157 -0.127
ENSG00000142784 E002 5.4006121 0.0289017176 3.486136e-01 4.928495e-01 1 27234632 27234667 36 + 0.856 0.735 -0.479
ENSG00000142784 E003 6.1682887 0.0050751692 7.702319e-01 8.516197e-01 1 27234668 27234687 20 + 0.827 0.803 -0.094
ENSG00000142784 E004 10.6528096 0.0056932708 1.595937e-01 2.745793e-01 1 27234688 27234734 47 + 0.884 1.068 0.683
ENSG00000142784 E005 9.7368227 0.0048340478 1.309414e-02 3.612572e-02 1 27234735 27234737 3 + 0.723 1.059 1.289
ENSG00000142784 E006 13.3665697 0.0013312249 1.387473e-02 3.794373e-02 1 27234738 27234763 26 + 0.884 1.171 1.052
ENSG00000142784 E007 55.8424088 0.0112415436 8.880180e-01 9.324241e-01 1 27234764 27234951 188 + 1.678 1.710 0.109
ENSG00000142784 E008 1.4913791 0.7481079306 3.792924e-01 5.235548e-01 1 27260333 27260382 50 + 0.677 0.157 -3.112
ENSG00000142784 E009 108.0901763 0.0041054623 6.469494e-02 1.345408e-01 1 27260956 27261047 92 + 2.032 1.965 -0.225
ENSG00000142784 E010 127.1921854 0.0002376789 2.153600e-04 1.029948e-03 1 27261048 27261102 55 + 2.131 2.025 -0.355
ENSG00000142784 E011 171.9320696 0.0002144328 1.387998e-02 3.795496e-02 1 27263152 27263235 84 + 2.225 2.171 -0.181
ENSG00000142784 E012 2.0294685 0.0156249003 4.498688e-01 5.910694e-01 1 27272538 27272634 97 + 0.529 0.408 -0.609
ENSG00000142784 E013 145.8324166 0.0003096245 2.063045e-01 3.340889e-01 1 27282239 27282285 47 + 2.134 2.111 -0.077
ENSG00000142784 E014 209.7283518 0.0002759202 1.489781e-05 9.515660e-05 1 27283338 27283449 112 + 2.340 2.243 -0.324
ENSG00000142784 E015 154.0756035 0.0013912137 2.104260e-05 1.298393e-04 1 27287674 27287708 35 + 2.227 2.099 -0.427
ENSG00000142784 E016 279.7956468 0.0010667377 2.618749e-06 1.986767e-05 1 27287709 27287861 153 + 2.471 2.365 -0.353
ENSG00000142784 E017 300.0205012 0.0004265168 3.327700e-05 1.956680e-04 1 27292215 27292397 183 + 2.482 2.404 -0.261
ENSG00000142784 E018 253.1611749 0.0002502105 8.406499e-06 5.682125e-05 1 27294022 27294116 95 + 2.417 2.327 -0.300
ENSG00000142784 E019 242.3969376 0.0001664332 2.401310e-04 1.133844e-03 1 27294514 27294629 116 + 2.387 2.315 -0.240
ENSG00000142784 E020 197.8794427 0.0002297544 1.168961e-01 2.155417e-01 1 27296326 27296401 76 + 2.266 2.241 -0.085
ENSG00000142784 E021 111.2473209 0.0005692418 3.267221e-01 4.701808e-01 1 27297048 27297050 3 + 2.012 1.993 -0.064
ENSG00000142784 E022 274.2501056 0.0023360956 3.009143e-01 4.426915e-01 1 27297051 27297156 106 + 2.400 2.387 -0.043
ENSG00000142784 E023 369.9592429 0.0001740807 6.598029e-01 7.685496e-01 1 27297938 27298111 174 + 2.512 2.521 0.030
ENSG00000142784 E024 347.0529303 0.0014399449 9.615202e-01 9.797589e-01 1 27301226 27301461 236 + 2.478 2.497 0.062
ENSG00000142784 E025 230.9476687 0.0002068406 4.983365e-01 6.348061e-01 1 27303621 27303795 175 + 2.315 2.315 0.001
ENSG00000142784 E026 23.3674780 0.0007996630 3.536992e-02 8.236300e-02 1 27303796 27305000 1205 + 1.434 1.295 -0.484
ENSG00000142784 E027 120.8008477 0.0010942039 6.045488e-01 7.250556e-01 1 27305001 27305013 13 + 2.037 2.035 -0.006
ENSG00000142784 E028 151.2471687 0.0002646253 4.384465e-02 9.810131e-02 1 27305014 27305058 45 + 2.165 2.119 -0.153
ENSG00000142784 E029 285.7116833 0.0001676702 3.764886e-01 5.208079e-01 1 27305059 27305193 135 + 2.407 2.405 -0.009
ENSG00000142784 E030 400.1519177 0.0001574415 2.376564e-01 3.714425e-01 1 27306186 27306450 265 + 2.521 2.563 0.138
ENSG00000142784 E031 389.9419441 0.0001805736 1.852630e-07 1.786497e-06 1 27306451 27306707 257 + 2.446 2.573 0.421
ENSG00000142784 E032 844.1164505 0.0011122901 1.042541e-09 1.540851e-08 1 27306708 27307443 736 + 2.772 2.913 0.469
ENSG00000142784 E033 517.1509462 0.0084286431 1.527519e-06 1.219280e-05 1 27307444 27308169 726 + 2.477 2.723 0.818
ENSG00000142784 E034 52.5702625 0.0004593574 7.341526e-09 9.271583e-08 1 27308170 27308636 467 + 1.386 1.757 1.267