ENSG00000142751

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374133 ENSG00000142751 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN2 protein_coding protein_coding 37.23536 61.4295 23.61462 1.378617 0.3433014 -1.378875 13.328583 25.240307 5.562020 1.1685353 0.3679122 -2.1800286 0.33961250 0.41183333 0.2351667 -0.176666667 7.509149e-05 7.509149e-05 FALSE TRUE
ENST00000374135 ENSG00000142751 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN2 protein_coding protein_coding 37.23536 61.4295 23.61462 1.378617 0.3433014 -1.378875 9.443649 13.258800 8.284769 0.7257957 0.1326251 -0.6777641 0.27747917 0.21650000 0.3509000 0.134400000 8.098650e-05 7.509149e-05 FALSE TRUE
MSTRG.627.2 ENSG00000142751 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN2 protein_coding   37.23536 61.4295 23.61462 1.378617 0.3433014 -1.378875 8.717517 14.026213 5.566762 1.5559244 0.7626897 -1.3316543 0.22897917 0.22756667 0.2355333 0.007966667 9.679259e-01 7.509149e-05 FALSE TRUE
MSTRG.627.5 ENSG00000142751 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN2 protein_coding   37.23536 61.4295 23.61462 1.378617 0.3433014 -1.378875 1.153336 1.115990 1.667823 0.5571738 0.1988250 0.5753956 0.04129583 0.01776667 0.0707000 0.052933333 5.519679e-02 7.509149e-05 TRUE TRUE
MSTRG.627.6 ENSG00000142751 HEK293_OSMI2_2hA HEK293_TMG_2hB GPN2 protein_coding   37.23536 61.4295 23.61462 1.378617 0.3433014 -1.378875 3.732302 6.684838 1.993140 1.3149953 0.9967273 -1.7407857 0.08665833 0.10836667 0.0849000 -0.023466667 8.275163e-01 7.509149e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142751 E001 0.9952782 0.0123913263 4.675253e-01 6.070377e-01 1 26876132 26876147 16 - 0.179 0.310 1.031
ENSG00000142751 E002 10.6581866 0.0325968597 6.957264e-01 7.962495e-01 1 26876148 26876173 26 - 1.067 0.996 -0.260
ENSG00000142751 E003 28.9392465 0.0030283303 1.212078e-01 2.216582e-01 1 26876174 26876208 35 - 1.512 1.389 -0.426
ENSG00000142751 E004 91.1094277 0.0171254718 9.237220e-01 9.559509e-01 1 26876209 26876346 138 - 1.905 1.908 0.010
ENSG00000142751 E005 693.3439409 0.0046115778 1.032704e-02 2.957471e-02 1 26876347 26878415 2069 - 2.848 2.756 -0.305
ENSG00000142751 E006 16.1550127 0.0011686133 6.167229e-01 7.347246e-01 1 26878416 26878511 96 - 1.153 1.187 0.119
ENSG00000142751 E007 96.3121867 0.0003290088 5.974882e-08 6.338467e-07 1 26878512 26878828 317 - 2.081 1.863 -0.731
ENSG00000142751 E008 178.5184208 0.0002841878 2.708305e-16 1.106015e-14 1 26878829 26879375 547 - 2.359 2.116 -0.809
ENSG00000142751 E009 187.6658553 0.0002445871 7.679290e-01 8.500452e-01 1 26879376 26879500 125 - 2.221 2.215 -0.019
ENSG00000142751 E010 431.4226954 0.0002497214 2.990923e-07 2.768824e-06 1 26879501 26879749 249 - 2.508 2.597 0.294
ENSG00000142751 E011 28.8410318 0.0181654865 4.374880e-02 9.792731e-02 1 26884125 26884159 35 - 1.558 1.353 -0.707
ENSG00000142751 E012 311.8718924 0.0001667732 4.482510e-04 1.960291e-03 1 26884160 26884232 73 - 2.385 2.451 0.219
ENSG00000142751 E013 282.8320376 0.0002136831 2.157913e-03 7.713983e-03 1 26884233 26884290 58 - 2.345 2.405 0.199
ENSG00000142751 E014 316.4542422 0.0001820782 8.445950e-02 1.665393e-01 1 26885973 26886041 69 - 2.422 2.446 0.081
ENSG00000142751 E015 350.7873505 0.0002675251 7.663627e-02 1.541096e-01 1 26886042 26886133 92 - 2.468 2.492 0.080
ENSG00000142751 E016 2.5765562 0.0058786620 3.973306e-01 5.410854e-01 1 26886134 26886341 208 - 0.402 0.544 0.711
ENSG00000142751 E017 2.3625495 0.2578089757 1.924738e-01 3.168708e-01 1 26886477 26886525 49 - 0.705 0.360 -1.657
ENSG00000142751 E018 2.6538623 0.0057097051 8.930759e-01 9.356694e-01 1 26888897 26888968 72 - 0.549 0.517 -0.152
ENSG00000142751 E019 376.0033707 0.0002332798 1.672391e-02 4.433040e-02 1 26888969 26889125 157 - 2.488 2.524 0.118
ENSG00000142751 E020 2.6518122 0.0377037216 8.954777e-01 9.372244e-01 1 26889126 26889155 30 - 0.550 0.516 -0.156
ENSG00000142751 E021 184.5205431 0.0002618890 5.914357e-02 1.251642e-01 1 26889686 26889732 47 - 2.175 2.217 0.140
ENSG00000142751 E022 142.3223448 0.0003704185 5.441714e-01 6.746835e-01 1 26889733 26889754 22 - 2.088 2.095 0.021
ENSG00000142751 E023 268.1154627 0.0030820818 8.129726e-01 8.814015e-01 1 26889755 26889944 190 - 2.372 2.365 -0.022
ENSG00000142751 E024 351.3540887 0.0060363670 3.235725e-01 4.668910e-01 1 26889945 26890444 500 - 2.525 2.471 -0.180