ENSG00000142733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357582 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding protein_coding 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 1.6237869 2.0158155 1.7074243 0.7780829 0.08095914 -0.23825628 0.14997917 0.13200000 0.22210000 0.09010000 0.4053375318 0.0009321205 FALSE TRUE
ENST00000374040 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding protein_coding 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 1.1230549 1.1287375 0.8645296 0.4687538 0.05531033 -0.38085600 0.09995833 0.06410000 0.11113333 0.04703333 0.2417531101 0.0009321205 FALSE TRUE
ENST00000470890 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding retained_intron 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 1.1296581 0.7452276 0.9411882 0.2211616 0.16697500 0.33281931 0.10434583 0.04423333 0.11983333 0.07560000 0.0356219050 0.0009321205 FALSE TRUE
ENST00000476509 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding retained_intron 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 0.7747980 0.6501237 0.5905888 0.2041729 0.07263931 -0.13635889 0.07427083 0.03753333 0.07560000 0.03806667 0.0919272303 0.0009321205 FALSE FALSE
ENST00000486046 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding protein_coding 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 3.3584531 6.1117165 1.9261597 1.0858088 0.40201011 -1.66073826 0.26130417 0.36433333 0.24646667 -0.11786667 0.2383146577 0.0009321205   FALSE
ENST00000493901 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding retained_intron 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 2.4429290 4.8406167 0.9592367 0.6206175 0.11172216 -2.32324718 0.19479583 0.29543333 0.12390000 -0.17153333 0.0009321205 0.0009321205 FALSE TRUE
ENST00000671291 ENSG00000142733 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K6 protein_coding retained_intron 11.69857 16.52625 7.776891 1.837827 0.4609803 -1.086513 0.6394948 0.5407409 0.5085360 0.2324215 0.13055364 -0.08692942 0.06188333 0.03433333 0.06453333 0.03020000 0.5093488181 0.0009321205 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142733 E001 0.7394768 0.0185924313 1.931647e-01 3.177459e-01 1 27354067 27354305 239 - 0.001 0.264 9.406
ENSG00000142733 E002 2.1681952 0.0071396750 2.954251e-01 4.365530e-01 1 27355184 27355185 2 - 0.303 0.491 1.053
ENSG00000142733 E003 15.0876721 0.0012474960 1.558739e-01 2.696124e-01 1 27355186 27355207 22 - 1.046 1.177 0.475
ENSG00000142733 E004 44.4560063 0.0005381712 9.171560e-02 1.778101e-01 1 27355208 27355277 70 - 1.530 1.620 0.308
ENSG00000142733 E005 75.2866742 0.0087291127 2.140365e-01 3.433062e-01 1 27355278 27355355 78 - 1.772 1.843 0.242
ENSG00000142733 E006 112.9932672 0.0089262977 1.622601e-01 2.780588e-01 1 27355356 27355469 114 - 1.942 2.017 0.254
ENSG00000142733 E007 83.2667232 0.0088522809 2.644473e-01 4.024164e-01 1 27355669 27355745 77 - 1.821 1.884 0.212
ENSG00000142733 E008 81.7344647 0.0014887296 6.962300e-03 2.112508e-02 1 27356026 27356099 74 - 1.768 1.887 0.400
ENSG00000142733 E009 92.1261139 0.0042626497 1.900872e-03 6.917563e-03 1 27356388 27356500 113 - 1.786 1.943 0.528
ENSG00000142733 E010 95.3340163 0.0094880106 3.504139e-02 8.172985e-02 1 27356590 27356749 160 - 1.827 1.954 0.426
ENSG00000142733 E011 18.2896514 0.0186582052 7.216484e-06 4.953052e-05 1 27356750 27357008 259 - 1.516 1.060 -1.602
ENSG00000142733 E012 71.6568613 0.0005369413 1.961640e-06 1.528762e-05 1 27357009 27357114 106 - 1.612 1.844 0.785
ENSG00000142733 E013 3.3913551 0.0046840885 2.811639e-03 9.709087e-03 1 27357115 27357165 51 - 0.879 0.428 -1.970
ENSG00000142733 E014 6.1258305 0.0312728028 5.818136e-02 1.235123e-01 1 27357166 27357399 234 - 0.982 0.700 -1.096
ENSG00000142733 E015 87.9012129 0.0041307948 2.676147e-03 9.301784e-03 1 27357400 27357576 177 - 1.768 1.920 0.512
ENSG00000142733 E016 0.2998086 0.0297176017 5.315930e-01   1 27357577 27357614 38 - 0.178 0.082 -1.273
ENSG00000142733 E017 83.4349993 0.0003512550 4.213738e-03 1.374070e-02 1 27357711 27357876 166 - 1.775 1.892 0.392
ENSG00000142733 E018 9.4437031 0.0540416089 1.270088e-01 2.299739e-01 1 27357877 27358180 304 - 1.118 0.884 -0.865
ENSG00000142733 E019 65.3017710 0.0054546305 1.973683e-02 5.093147e-02 1 27358181 27358319 139 - 1.663 1.795 0.449
ENSG00000142733 E020 2.3197132 0.0064582955 1.204888e-01 2.206616e-01 1 27358320 27358418 99 - 0.657 0.392 -1.269
ENSG00000142733 E021 73.6864296 0.0003479520 1.988246e-01 3.247271e-01 1 27358419 27358611 193 - 1.775 1.824 0.162
ENSG00000142733 E022 65.3579008 0.0014899830 8.834195e-01 9.294176e-01 1 27358709 27358866 158 - 1.760 1.757 -0.013
ENSG00000142733 E023 59.7301526 0.0099409758 6.911477e-01 7.926859e-01 1 27359417 27359522 106 - 1.749 1.711 -0.129
ENSG00000142733 E024 62.0631304 0.0101039937 3.141605e-01 4.568443e-01 1 27359858 27359994 137 - 1.790 1.715 -0.254
ENSG00000142733 E025 56.3588333 0.0149397722 5.715634e-01 6.978260e-01 1 27360241 27360368 128 - 1.733 1.681 -0.176
ENSG00000142733 E026 51.1446085 0.0142783163 8.420099e-01 9.014837e-01 1 27360705 27360838 134 - 1.672 1.648 -0.082
ENSG00000142733 E027 34.3254704 0.0006525619 6.428661e-02 1.338474e-01 1 27360921 27361008 88 - 1.579 1.451 -0.437
ENSG00000142733 E028 34.9499238 0.0080826767 1.654291e-01 2.822563e-01 1 27361157 27361252 96 - 1.579 1.464 -0.392
ENSG00000142733 E029 29.4099165 0.0007314799 2.333538e-01 3.663924e-01 1 27361346 27361395 50 - 1.489 1.396 -0.319
ENSG00000142733 E030 42.9278324 0.0005665871 4.050877e-01 5.487694e-01 1 27361520 27361627 108 - 1.628 1.569 -0.201
ENSG00000142733 E031 52.0240410 0.0066208998 8.454105e-01 9.038708e-01 1 27361705 27361867 163 - 1.663 1.666 0.011
ENSG00000142733 E032 48.4859252 0.0006015429 7.342438e-01 8.252418e-01 1 27362091 27362250 160 - 1.623 1.631 0.028
ENSG00000142733 E033 41.9960739 0.0010720324 2.553340e-01 3.921959e-01 1 27362641 27362753 113 - 1.623 1.544 -0.267
ENSG00000142733 E034 44.4091190 0.0103019946 9.842052e-03 2.837559e-02 1 27362851 27363021 171 - 1.725 1.532 -0.654
ENSG00000142733 E035 36.9877417 0.0036153385 5.623893e-01 6.899959e-01 1 27363442 27363548 107 - 1.549 1.499 -0.169
ENSG00000142733 E036 51.1342243 0.0098377275 4.955270e-02 1.083682e-01 1 27363917 27364085 169 - 1.753 1.611 -0.481
ENSG00000142733 E037 46.8842939 0.0099886899 5.856175e-04 2.480570e-03 1 27364204 27364394 191 - 1.783 1.537 -0.836
ENSG00000142733 E038 13.0529360 0.0013927570 8.347666e-07 7.052131e-06 1 27364661 27364684 24 - 1.376 0.910 -1.673
ENSG00000142733 E039 6.5196514 0.0025108912 1.782461e-08 2.097070e-07 1 27364685 27364768 84 - 1.208 0.519 -2.717
ENSG00000142733 E040 25.3669613 0.0269700233 2.177407e-03 7.771643e-03 1 27364773 27364912 140 - 1.567 1.250 -1.095
ENSG00000142733 E041 48.5441381 0.0606257141 3.612653e-03 1.204559e-02 1 27366258 27366961 704 - 1.865 1.513 -1.195