ENSG00000142687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325722 ENSG00000142687 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0319L protein_coding protein_coding 29.9137 32.2498 26.10229 1.283379 0.5853536 -0.3050081 18.2896225 22.390844 15.5859949 1.1924634 0.6458708 -0.5223775 0.60886667 0.6936 0.59846667 -0.095133333 1.796543e-01 1.820701e-36 FALSE TRUE
ENST00000373266 ENSG00000142687 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0319L protein_coding protein_coding 29.9137 32.2498 26.10229 1.283379 0.5853536 -0.3050081 1.9606145 4.445982 0.0000000 0.2509455 0.0000000 -8.7995995 0.05902500 0.1386 0.00000000 -0.138600000 1.820701e-36 1.820701e-36 FALSE TRUE
ENST00000426982 ENSG00000142687 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0319L protein_coding protein_coding 29.9137 32.2498 26.10229 1.283379 0.5853536 -0.3050081 0.5374481 0.000000 1.6618392 0.0000000 0.2108982 7.3852922 0.02014167 0.0000 0.06356667 0.063566667 1.313842e-21 1.820701e-36 FALSE TRUE
ENST00000461312 ENSG00000142687 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0319L protein_coding processed_transcript 29.9137 32.2498 26.10229 1.283379 0.5853536 -0.3050081 1.6000719 1.317437 0.9326896 0.2614528 0.1283207 -0.4937883 0.05151667 0.0411 0.03553333 -0.005566667 8.733153e-01 1.820701e-36 FALSE TRUE
MSTRG.826.3 ENSG00000142687 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0319L protein_coding   29.9137 32.2498 26.10229 1.283379 0.5853536 -0.3050081 2.7112422 1.064174 3.4133449 0.4649586 0.2477935 1.6721784 0.09655000 0.0321 0.13053333 0.098433333 3.519190e-03 1.820701e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142687 E001 478.4056558 0.0057560161 6.315515e-08 6.666975e-07 1 35433492 35434104 613 - 2.515 2.744 0.761
ENSG00000142687 E002 108.3218506 0.0030372566 3.579319e-04 1.610783e-03 1 35434105 35434206 102 - 1.916 2.089 0.581
ENSG00000142687 E003 577.2303284 0.0014267319 2.527210e-11 4.929191e-10 1 35434207 35434964 758 - 2.641 2.808 0.557
ENSG00000142687 E004 264.0602566 0.0009649726 5.965931e-05 3.297432e-04 1 35434965 35435081 117 - 2.334 2.455 0.405
ENSG00000142687 E005 15.0944424 0.0084573094 3.859801e-01 5.301852e-01 1 35435304 35435597 294 - 1.139 1.238 0.354
ENSG00000142687 E006 33.2522088 0.0006061939 4.433409e-05 2.529808e-04 1 35438542 35441046 2505 - 1.648 1.417 -0.792
ENSG00000142687 E007 262.4373947 0.0035943066 8.327860e-02 1.646959e-01 1 35441047 35441138 92 - 2.360 2.437 0.255
ENSG00000142687 E008 145.6136254 0.0011949617 6.776471e-01 7.823121e-01 1 35442246 35442266 21 - 2.138 2.167 0.095
ENSG00000142687 E009 204.6381319 0.0013924176 9.413704e-01 9.671460e-01 1 35442267 35442336 70 - 2.296 2.308 0.042
ENSG00000142687 E010 274.9599022 0.0002035772 1.278836e-01 2.312216e-01 1 35442906 35443028 123 - 2.397 2.446 0.162
ENSG00000142687 E011 6.8049686 0.0615124408 6.700925e-01 7.766576e-01 1 35443029 35443255 227 - 0.911 0.847 -0.245
ENSG00000142687 E012 2.5808132 0.0185153186 2.777226e-01 4.173449e-01 1 35443262 35443335 74 - 0.641 0.474 -0.772
ENSG00000142687 E013 2.9860274 0.0070044821 1.759493e-01 2.959318e-01 1 35444036 35444160 125 - 0.710 0.513 -0.870
ENSG00000142687 E014 131.5401882 0.0002359722 2.284220e-01 3.605314e-01 1 35444161 35444164 4 - 2.076 2.129 0.177
ENSG00000142687 E015 292.7115264 0.0029046987 7.195886e-02 1.465912e-01 1 35444165 35444303 139 - 2.408 2.481 0.243
ENSG00000142687 E016 253.7942361 0.0014011301 5.164939e-03 1.637737e-02 1 35448173 35448332 160 - 2.333 2.427 0.314
ENSG00000142687 E017 247.8374436 0.0001705203 3.820318e-01 5.262890e-01 1 35449867 35450005 139 - 2.363 2.398 0.116
ENSG00000142687 E018 1.2189160 0.0100921227 2.515836e-01 3.878408e-01 1 35450006 35450006 1 - 0.459 0.266 -1.148
ENSG00000142687 E019 116.8417482 0.0020230066 8.540434e-01 9.096969e-01 1 35450358 35450364 7 - 2.058 2.067 0.029
ENSG00000142687 E020 252.4296971 0.0005289443 9.304905e-01 9.602854e-01 1 35450365 35450509 145 - 2.383 2.400 0.058
ENSG00000142687 E021 109.8757310 0.0003028252 8.315961e-01 8.944638e-01 1 35451628 35451634 7 - 2.028 2.036 0.024
ENSG00000142687 E022 199.5927207 0.0002979482 8.173747e-01 8.845290e-01 1 35451635 35451776 142 - 2.279 2.300 0.070
ENSG00000142687 E023 1.6565209 0.0087446086 8.940017e-01 9.362251e-01 1 35451777 35451791 15 - 0.398 0.430 0.175
ENSG00000142687 E024 0.2214452 0.0422365050 6.402698e-01   1 35453553 35453556 4 - 0.000 0.108 9.556
ENSG00000142687 E025 192.1468486 0.0002049850 8.504566e-01 9.072230e-01 1 35453557 35453689 133 - 2.269 2.279 0.033
ENSG00000142687 E026 0.0000000       1 35454237 35454361 125 -      
ENSG00000142687 E027 189.1904233 0.0002131799 5.664703e-01 6.934499e-01 1 35454362 35454485 124 - 2.268 2.268 -0.002
ENSG00000142687 E028 0.6966155 0.0172671820 4.806648e-01 6.188996e-01 1 35454486 35454613 128 - 0.138 0.267 1.176
ENSG00000142687 E029 0.4815130 0.0202949482 7.655220e-01 8.482531e-01 1 35454614 35454707 94 - 0.138 0.194 0.589
ENSG00000142687 E030 252.2410053 0.0001774119 2.028806e-03 7.315983e-03 1 35456013 35456241 229 - 2.426 2.371 -0.185
ENSG00000142687 E031 88.5317862 0.0005439938 4.149165e-01 5.583274e-01 1 35460305 35460307 3 - 1.954 1.937 -0.056
ENSG00000142687 E032 151.3164550 0.0002287466 1.042899e-01 1.970204e-01 1 35460308 35460373 66 - 2.192 2.159 -0.110
ENSG00000142687 E033 127.8752520 0.0003294905 7.689864e-04 3.146551e-03 1 35460374 35460433 60 - 2.151 2.058 -0.312
ENSG00000142687 E034 80.3343336 0.0005184651 1.647475e-03 6.112598e-03 1 35460434 35460437 4 - 1.961 1.848 -0.379
ENSG00000142687 E035 159.8285826 0.0002571070 6.187315e-07 5.374365e-06 1 35462621 35462713 93 - 2.268 2.141 -0.424
ENSG00000142687 E036 88.4134281 0.0042514678 6.548114e-02 1.358447e-01 1 35466608 35466609 2 - 1.985 1.911 -0.248
ENSG00000142687 E037 168.8664819 0.0026834169 2.873733e-03 9.894409e-03 1 35466610 35466695 86 - 2.275 2.182 -0.311
ENSG00000142687 E038 175.7325529 0.0010498331 2.120778e-03 7.598295e-03 1 35470863 35470960 98 - 2.283 2.205 -0.263
ENSG00000142687 E039 139.2357678 0.0008669209 1.391100e-02 3.802442e-02 1 35474805 35474868 64 - 2.173 2.106 -0.223
ENSG00000142687 E040 94.7552404 0.0044646230 2.033076e-01 3.303431e-01 1 35474869 35474906 38 - 1.995 1.947 -0.161
ENSG00000142687 E041 143.2585929 0.0070618225 2.077601e-01 3.357846e-01 1 35478966 35479059 94 - 2.176 2.125 -0.172
ENSG00000142687 E042 183.2122797 0.0018470104 1.272297e-04 6.466862e-04 1 35479060 35479212 153 - 2.318 2.205 -0.377
ENSG00000142687 E043 146.3923292 0.0036114120 1.193488e-04 6.108903e-04 1 35506612 35506738 127 - 2.237 2.095 -0.475
ENSG00000142687 E044 261.2983503 0.0034750764 2.018953e-05 1.250849e-04 1 35506739 35507135 397 - 2.484 2.349 -0.450
ENSG00000142687 E045 0.4482035 0.0310184176 4.699518e-02 1.038201e-01 1 35533096 35533441 346 - 0.327 0.000 -12.229
ENSG00000142687 E046 144.9748262 0.0002633457 3.426539e-08 3.815597e-07 1 35554350 35554519 170 - 2.238 2.088 -0.501
ENSG00000142687 E047 0.0000000       1 35554789 35554899 111 -      
ENSG00000142687 E048 0.0000000       1 35554900 35554987 88 -      
ENSG00000142687 E049 0.1451727 0.0432355460 3.651555e-01   1 35556471 35556757 287 - 0.138 0.000 -10.642
ENSG00000142687 E050 1.6167525 0.0087948531 2.128638e-01 3.419014e-01 1 35557048 35557206 159 - 0.243 0.474 1.399
ENSG00000142687 E051 69.4221826 0.0004611234 3.172753e-03 1.077512e-02 1 35557207 35557303 97 - 1.902 1.790 -0.376
ENSG00000142687 E052 48.7165984 0.0005425562 2.012368e-02 5.174425e-02 1 35557304 35557361 58 - 1.743 1.640 -0.351
ENSG00000142687 E053 43.2397414 0.0005334017 3.875011e-03 1.279226e-02 1 35557362 35557410 49 - 1.713 1.573 -0.475
ENSG00000142687 E054 5.1481122 0.0536692113 2.934690e-02 7.067541e-02 1 35557550 35557655 106 - 0.948 0.616 -1.330
ENSG00000142687 E055 0.5212538 0.0215294902 7.632157e-01 8.466168e-01 1 35557711 35557950 240 - 0.138 0.194 0.590