ENSG00000142675

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361530 ENSG00000142675 HEK293_OSMI2_2hA HEK293_TMG_2hB CNKSR1 protein_coding protein_coding 1.833958 2.029734 2.068123 0.3376451 0.5770608 0.02689998 0.47476622 0.6196829 0.7895664 0.15043026 0.05027389 0.3445923 0.26609583 0.31793333 0.42596667 0.1080333 0.695840356 0.005882341 FALSE  
ENST00000374253 ENSG00000142675 HEK293_OSMI2_2hA HEK293_TMG_2hB CNKSR1 protein_coding protein_coding 1.833958 2.029734 2.068123 0.3376451 0.5770608 0.02689998 0.19905631 0.2168214 0.0000000 0.10983844 0.00000000 -4.5034846 0.11952083 0.10996667 0.00000000 -0.1099667 0.120780700 0.005882341 FALSE  
ENST00000480617 ENSG00000142675 HEK293_OSMI2_2hA HEK293_TMG_2hB CNKSR1 protein_coding retained_intron 1.833958 2.029734 2.068123 0.3376451 0.5770608 0.02689998 0.63728007 0.8936520 0.6516766 0.23569257 0.35614545 -0.4496410 0.32514167 0.42773333 0.27133333 -0.1564000 0.430936706 0.005882341    
ENST00000484874 ENSG00000142675 HEK293_OSMI2_2hA HEK293_TMG_2hB CNKSR1 protein_coding retained_intron 1.833958 2.029734 2.068123 0.3376451 0.5770608 0.02689998 0.18150136 0.1979898 0.1612260 0.05774763 0.11800976 -0.2806114 0.09552083 0.09473333 0.06323333 -0.0315000 0.759396995 0.005882341    
ENST00000525687 ENSG00000142675 HEK293_OSMI2_2hA HEK293_TMG_2hB CNKSR1 protein_coding nonsense_mediated_decay 1.833958 2.029734 2.068123 0.3376451 0.5770608 0.02689998 0.06167648 0.0000000 0.1363401 0.00000000 0.02366689 3.8712532 0.03546250 0.00000000 0.07560000 0.0756000 0.005882341 0.005882341 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142675 E001 1.1008118 0.012278807 0.60736611 0.72736781 1 26177484 26177489 6 + 0.375 0.285 -0.569
ENSG00000142675 E002 1.2523272 0.010917181 0.39480329 0.53863486 1 26177490 26177490 1 + 0.434 0.285 -0.891
ENSG00000142675 E003 1.2523272 0.010917181 0.39480329 0.53863486 1 26177491 26177502 12 + 0.434 0.285 -0.891
ENSG00000142675 E004 0.9233738 0.013873598 0.34644489 0.49057790 1 26177503 26177508 6 + 0.375 0.209 -1.154
ENSG00000142675 E005 1.1416099 0.013832218 0.81309476 0.88148856 1 26177509 26177511 3 + 0.307 0.349 0.261
ENSG00000142675 E006 1.8811884 0.009065485 0.89614179 0.93763703 1 26177512 26177580 69 + 0.434 0.455 0.111
ENSG00000142675 E007 1.2512805 0.011230678 0.31243938 0.45496894 1 26177581 26177599 19 + 0.227 0.406 1.170
ENSG00000142675 E008 0.0000000       1 26180168 26180452 285 +      
ENSG00000142675 E009 4.9705554 0.004729670 0.78115029 0.85939279 1 26180453 26180610 158 + 0.737 0.774 0.149
ENSG00000142675 E010 7.8919661 0.002274936 0.16711325 0.28444582 1 26180715 26180896 182 + 1.026 0.874 -0.568
ENSG00000142675 E011 0.7019140 0.017267182 0.91908416 0.95288977 1 26180897 26181083 187 + 0.227 0.209 -0.151
ENSG00000142675 E012 0.4783925 0.020951326 0.50802677 0.64346796 1 26181587 26181856 270 + 0.227 0.117 -1.153
ENSG00000142675 E013 5.0908537 0.003366486 0.08601588 0.16901716 1 26181857 26181941 85 + 0.896 0.672 -0.890
ENSG00000142675 E014 0.1451727 0.043816062 0.44388932   1 26182005 26182054 50 + 0.128 0.000 -10.885
ENSG00000142675 E015 0.1451727 0.043816062 0.44388932   1 26182055 26182082 28 + 0.128 0.000 -10.885
ENSG00000142675 E016 2.6741277 0.007067890 0.05573697 0.11924246 1 26182361 26182398 38 + 0.709 0.405 -1.417
ENSG00000142675 E017 1.6294274 0.010145085 0.43040035 0.57303733 1 26182399 26182402 4 + 0.486 0.349 -0.738
ENSG00000142675 E018 1.6251610 0.077990102 0.48239585 0.62053769 1 26182480 26182484 5 + 0.486 0.350 -0.735
ENSG00000142675 E019 2.8805069 0.056707169 0.83897477 0.89936033 1 26182485 26182584 100 + 0.574 0.608 0.156
ENSG00000142675 E020 1.4735689 0.025689435 0.02335357 0.05848506 1 26183197 26183203 7 + 0.128 0.539 2.840
ENSG00000142675 E021 2.8419225 0.005995745 0.13349283 0.23899309 1 26183204 26183256 53 + 0.434 0.672 1.109
ENSG00000142675 E022 3.6085721 0.004566431 0.80629164 0.87686299 1 26183346 26183414 69 + 0.679 0.643 -0.153
ENSG00000142675 E023 0.5514428 0.019805046 0.09987182 0.19028498 1 26183415 26183435 21 + 0.000 0.285 11.126
ENSG00000142675 E024 4.2946645 0.026846970 0.48790132 0.62553424 1 26183729 26183830 102 + 0.646 0.753 0.442
ENSG00000142675 E025 3.2785640 0.005130186 0.02631201 0.06457575 1 26184071 26184141 71 + 0.789 0.455 -1.475
ENSG00000142675 E026 1.7089367 0.008854039 0.09147814 0.17744233 1 26184142 26184213 72 + 0.574 0.285 -1.569
ENSG00000142675 E027 6.0379574 0.002979229 0.62816847 0.74377155 1 26184214 26184287 74 + 0.876 0.817 -0.231
ENSG00000142675 E028 4.7565766 0.011671827 0.04033736 0.09164798 1 26184401 26184507 107 + 0.896 0.611 -1.153
ENSG00000142675 E029 3.2827156 0.006972160 0.18615910 0.30892854 1 26184585 26184612 28 + 0.737 0.540 -0.855
ENSG00000142675 E030 1.1071545 0.012049162 0.60830327 0.72807999 1 26185014 26185050 37 + 0.375 0.285 -0.569
ENSG00000142675 E031 2.8743797 0.005788994 0.49079197 0.62813084 1 26185051 26185186 136 + 0.647 0.540 -0.476
ENSG00000142675 E032 6.1740667 0.038784518 0.21870353 0.34886028 1 26186915 26187167 253 + 0.738 0.911 0.676
ENSG00000142675 E033 6.0978854 0.002935740 0.41781281 0.56113273 1 26187168 26187241 74 + 0.896 0.796 -0.387
ENSG00000142675 E034 1.9144847 0.007809837 0.17465233 0.29424850 1 26187293 26187410 118 + 0.307 0.540 1.263
ENSG00000142675 E035 6.5927216 0.002885076 0.87385250 0.92291977 1 26187411 26187482 72 + 0.856 0.874 0.070
ENSG00000142675 E036 5.2867466 0.003580867 0.08777608 0.17175438 1 26188234 26188307 74 + 0.647 0.874 0.918
ENSG00000142675 E037 0.4502799 0.024206051 0.06953826 0.14259999 1 26188308 26188441 134 + 0.307 0.000 -12.226
ENSG00000142675 E038 6.9987893 0.002706566 0.15993579 0.27503114 1 26188442 26188503 62 + 0.789 0.956 0.641
ENSG00000142675 E039 8.6951648 0.002152754 0.13902355 0.24674531 1 26188598 26188697 100 + 0.876 1.037 0.600
ENSG00000142675 E040 13.9945002 0.001516763 0.27880733 0.41847275 1 26188772 26188953 182 + 1.114 1.207 0.332
ENSG00000142675 E041 23.2958391 0.001661335 0.13499339 0.24108161 1 26189279 26189884 606 + 1.320 1.420 0.346