ENSG00000142632

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449495 ENSG00000142632 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF19 protein_coding protein_coding 2.49852 3.906279 1.318861 0.3779093 0.1078258 -1.559293 0.3445212 0.43521150 0.3721054 0.26997353 0.09076215 -0.2205203 0.15210000 0.1080667 0.2775667 0.16950000 4.126603e-01 3.931126e-05 FALSE FALSE
ENST00000471928 ENSG00000142632 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF19 protein_coding processed_transcript 2.49852 3.906279 1.318861 0.3779093 0.1078258 -1.559293 0.1411968 0.08061855 0.1570874 0.04286747 0.08207758 0.8827248 0.06652917 0.0203000 0.1099000 0.08960000 3.841151e-01 3.931126e-05 FALSE FALSE
ENST00000478117 ENSG00000142632 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF19 protein_coding processed_transcript 2.49852 3.906279 1.318861 0.3779093 0.1078258 -1.559293 0.7889104 1.26104158 0.3980739 0.10841717 0.06090386 -1.6391088 0.31096667 0.3340333 0.3091000 -0.02493333 9.370038e-01 3.931126e-05 TRUE TRUE
ENST00000478210 ENSG00000142632 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF19 protein_coding processed_transcript 2.49852 3.906279 1.318861 0.3779093 0.1078258 -1.559293 0.2975762 0.53727770 0.0000000 0.12748355 0.00000000 -5.7742012 0.10951667 0.1351667 0.0000000 -0.13516667 3.931126e-05 3.931126e-05 TRUE FALSE
MSTRG.389.3 ENSG00000142632 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF19 protein_coding   2.49852 3.906279 1.318861 0.3779093 0.1078258 -1.559293 0.8571335 1.58074012 0.3625892 0.27676194 0.03926687 -2.0940405 0.33807500 0.3999333 0.2838000 -0.11613333 3.442613e-01 3.931126e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142632 E001 19.9742041 0.038643436 0.86391805 0.91625342 1 16197854 16198446 593 - 1.242 1.225 -0.060
ENSG00000142632 E002 34.1373654 0.001257276 0.38055018 0.52482395 1 16198447 16198744 298 - 1.394 1.451 0.198
ENSG00000142632 E003 21.9114577 0.002941971 0.29571135 0.43686010 1 16199150 16199254 105 - 1.177 1.269 0.325
ENSG00000142632 E004 18.3694064 0.001247837 0.16300822 0.27906325 1 16201782 16201861 80 - 1.285 1.158 -0.451
ENSG00000142632 E005 19.8524824 0.001084113 0.76388765 0.84711015 1 16202416 16202540 125 - 1.194 1.217 0.080
ENSG00000142632 E006 10.8579295 0.001912133 0.60317639 0.72402033 1 16202541 16202574 34 - 0.920 0.979 0.220
ENSG00000142632 E007 11.9637345 0.001703013 0.19909033 0.32508546 1 16204759 16204810 52 - 0.887 1.038 0.562
ENSG00000142632 E008 16.3462388 0.001151254 0.99241479 0.99934624 1 16204811 16204899 89 - 1.140 1.136 -0.014
ENSG00000142632 E009 11.6796962 0.037962067 0.71524321 0.81120174 1 16204900 16204919 20 - 0.951 1.009 0.217
ENSG00000142632 E010 17.0081571 0.012098714 0.56323331 0.69074071 1 16205087 16205176 90 - 1.100 1.161 0.219
ENSG00000142632 E011 15.8875952 0.007277183 0.78160684 0.85969038 1 16205351 16205425 75 - 1.159 1.125 -0.122
ENSG00000142632 E012 8.3930738 0.002171513 0.79285304 0.86754589 1 16205538 16205567 30 - 0.851 0.881 0.115
ENSG00000142632 E013 9.2016397 0.002295818 0.44264003 0.58422970 1 16205568 16205626 59 - 0.979 0.881 -0.369
ENSG00000142632 E014 8.1686970 0.004408901 0.35976963 0.50409577 1 16205627 16205667 41 - 0.951 0.829 -0.464
ENSG00000142632 E015 2.4077422 0.031081739 0.00334517 0.01127678 1 16205668 16205848 181 - 0.812 0.310 -2.398
ENSG00000142632 E016 1.0425076 0.045480912 0.55340898 0.68257443 1 16205849 16205930 82 - 0.346 0.229 -0.811
ENSG00000142632 E017 16.0731072 0.001668565 0.76712258 0.84942605 1 16205931 16206083 153 - 1.100 1.125 0.092
ENSG00000142632 E018 16.8343564 0.001275557 0.85442469 0.90993420 1 16206180 16206340 161 - 1.159 1.136 -0.080
ENSG00000142632 E019 5.6503563 0.077623337 0.34983632 0.49402163 1 16206341 16206543 203 - 0.851 0.691 -0.639
ENSG00000142632 E020 5.8697740 0.008213279 0.50844810 0.64385096 1 16206948 16207210 263 - 0.668 0.768 0.409
ENSG00000142632 E021 0.1515154 0.041943695 0.12938523   1 16207522 16207598 77 - 0.207 0.000 -13.264
ENSG00000142632 E022 0.1515154 0.041943695 0.12938523   1 16207675 16207777 103 - 0.207 0.000 -13.264
ENSG00000142632 E023 0.1515154 0.041943695 0.12938523   1 16207944 16208225 282 - 0.207 0.000 -13.264
ENSG00000142632 E024 0.2214452 0.037068274 1.00000000   1 16208643 16209083 441 - 0.000 0.070 9.633
ENSG00000142632 E025 0.0000000       1 16212502 16212652 151 -