ENSG00000142453

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327064 ENSG00000142453 HEK293_OSMI2_2hA HEK293_TMG_2hB CARM1 protein_coding protein_coding 75.68252 115.2063 52.67915 9.259607 0.948849 -1.128767 1.735625 0.00000 4.409372 0.000000 0.3776002 8.787698 0.0290125 0.0000000 0.0838000 0.083800000 4.227695e-49 4.227695e-49 FALSE  
ENST00000344150 ENSG00000142453 HEK293_OSMI2_2hA HEK293_TMG_2hB CARM1 protein_coding protein_coding 75.68252 115.2063 52.67915 9.259607 0.948849 -1.128767 58.229934 90.93881 41.629199 8.392143 1.1255699 -1.127112 0.7603833 0.7880667 0.7900333 0.001966667 1.000000e+00 4.227695e-49 FALSE  
MSTRG.16433.10 ENSG00000142453 HEK293_OSMI2_2hA HEK293_TMG_2hB CARM1 protein_coding   75.68252 115.2063 52.67915 9.259607 0.948849 -1.128767 8.708927 15.16285 2.456904 1.248100 0.5410774 -2.620719 0.1115417 0.1319000 0.0467000 -0.085200000 6.272630e-04 4.227695e-49 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142453 E001 0.294498 3.383327e-01 1.045700e-01   19 10871553 10871595 43 + 0.289 0.000 -11.864
ENSG00000142453 E002 3.818548 4.568953e-02 1.934842e-11 3.843854e-10 19 10871596 10871672 77 + 1.124 0.000 -15.785
ENSG00000142453 E003 5.587840 3.842056e-02 2.001542e-15 7.266884e-14 19 10871673 10871702 30 + 1.278 0.000 -16.332
ENSG00000142453 E004 14.380646 2.623034e-03 9.358055e-27 1.181116e-24 19 10871703 10871738 36 + 1.590 0.592 -3.704
ENSG00000142453 E005 23.704024 8.281263e-04 2.281822e-23 2.099487e-21 19 10871739 10871756 18 + 1.710 1.026 -2.385
ENSG00000142453 E006 105.109667 3.245783e-02 1.802031e-04 8.789182e-04 19 10871757 10871827 71 + 2.169 1.871 -0.997
ENSG00000142453 E007 137.415005 1.941328e-02 4.273219e-04 1.879313e-03 19 10871828 10871852 25 + 2.235 2.021 -0.718
ENSG00000142453 E008 214.657185 8.343783e-03 5.263186e-05 2.948937e-04 19 10871853 10871909 57 + 2.397 2.231 -0.552
ENSG00000142453 E009 179.822403 4.866075e-03 3.713507e-05 2.157153e-04 19 10871910 10871922 13 + 2.305 2.161 -0.482
ENSG00000142453 E010 2.565018 4.838301e-02 4.779590e-01 6.164208e-01 19 10872378 10872393 16 + 0.585 0.481 -0.489
ENSG00000142453 E011 11.493445 4.226374e-02 4.929480e-01 6.300431e-01 19 10872394 10872592 199 + 1.108 1.040 -0.248
ENSG00000142453 E012 479.807838 7.099846e-04 1.381688e-11 2.813679e-10 19 10904951 10905076 126 + 2.708 2.597 -0.372
ENSG00000142453 E013 618.727613 1.226879e-04 1.788218e-10 3.020978e-09 19 10908039 10908145 107 + 2.791 2.719 -0.241
ENSG00000142453 E014 6.811315 4.086267e-03 1.751241e-04 8.574573e-04 19 10908550 10908633 84 + 1.109 0.681 -1.640
ENSG00000142453 E015 5.883891 3.217708e-03 5.734631e-05 3.183335e-04 19 10908634 10908668 35 + 1.076 0.592 -1.906
ENSG00000142453 E016 7.560674 5.509444e-02 4.757208e-04 2.067251e-03 19 10908669 10908747 79 + 1.183 0.666 -1.970
ENSG00000142453 E017 720.839911 1.099827e-04 2.526937e-06 1.923037e-05 19 10909103 10909207 105 + 2.836 2.795 -0.136
ENSG00000142453 E018 777.033762 1.157160e-03 1.483014e-03 5.582209e-03 19 10912184 10912294 111 + 2.864 2.831 -0.110
ENSG00000142453 E019 1068.640758 5.471595e-04 5.206825e-03 1.649389e-02 19 10913877 10914054 178 + 2.987 2.975 -0.040
ENSG00000142453 E020 825.380728 1.594833e-04 2.069685e-01 3.349008e-01 19 10916407 10916497 91 + 2.857 2.868 0.035
ENSG00000142453 E021 831.760339 2.669426e-04 2.687713e-01 4.072536e-01 19 10916696 10916777 82 + 2.859 2.872 0.043
ENSG00000142453 E022 18.193354 2.220680e-02 7.787671e-04 3.182857e-03 19 10918986 10919594 609 + 1.440 1.113 -1.151
ENSG00000142453 E023 885.947639 4.632994e-04 3.588074e-01 5.031867e-01 19 10919595 10919680 86 + 2.887 2.902 0.052
ENSG00000142453 E024 12.415575 1.424794e-03 3.287310e-03 1.111296e-02 19 10919833 10919876 44 + 1.245 0.988 -0.927
ENSG00000142453 E025 660.336132 5.652735e-04 1.770621e-01 2.974170e-01 19 10919877 10919928 52 + 2.730 2.786 0.186
ENSG00000142453 E026 608.194653 7.616905e-04 3.593412e-01 5.036779e-01 19 10919929 10919966 38 + 2.699 2.748 0.166
ENSG00000142453 E027 990.667846 8.032018e-05 3.347023e-02 7.871924e-02 19 10920436 10920573 138 + 2.944 2.945 0.005
ENSG00000142453 E028 418.249053 1.314351e-04 6.392599e-04 2.677423e-03 19 10920659 10920662 4 + 2.597 2.559 -0.125
ENSG00000142453 E029 454.657444 1.405926e-04 4.587595e-02 1.018070e-01 19 10920663 10920666 4 + 2.613 2.603 -0.031
ENSG00000142453 E030 807.247982 1.895012e-04 8.098950e-01 8.793531e-01 19 10920667 10920748 82 + 2.832 2.864 0.108
ENSG00000142453 E031 896.973525 8.408762e-04 2.853107e-01 4.256273e-01 19 10920834 10920946 113 + 2.865 2.917 0.174
ENSG00000142453 E032 15.799249 1.175399e-03 5.094283e-02 1.108440e-01 19 10920947 10921049 103 + 1.000 1.222 0.799
ENSG00000142453 E033 772.638702 6.887885e-04 5.275936e-04 2.262820e-03 19 10921050 10921127 78 + 2.767 2.863 0.321
ENSG00000142453 E034 157.232089 6.135734e-03 5.740748e-02 1.221808e-01 19 10921375 10921443 69 + 2.052 2.182 0.434
ENSG00000142453 E035 9.288493 1.875765e-03 1.720048e-04 8.438198e-04 19 10921444 10921614 171 + 1.196 0.819 -1.393
ENSG00000142453 E036 3028.367308 3.398559e-03 2.678366e-15 9.584593e-14 19 10921615 10923075 1461 + 3.255 3.488 0.775