ENSG00000142230

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270225 ENSG00000142230 HEK293_OSMI2_2hA HEK293_TMG_2hB SAE1 protein_coding protein_coding 217.2175 265.2557 187.2675 20.44675 4.627526 -0.5022607 139.3419 180.88739 113.34321 11.487954 2.773783 -0.6743464 0.6394292 0.6837000 0.6052667 -0.07843333 0.01648254 0.007511243 FALSE TRUE
ENST00000597808 ENSG00000142230 HEK293_OSMI2_2hA HEK293_TMG_2hB SAE1 protein_coding protein_coding 217.2175 265.2557 187.2675 20.44675 4.627526 -0.5022607 46.5186 33.87753 52.96814 9.457641 2.222626 0.6446425 0.2217792 0.1312333 0.2826333 0.15140000 0.09406017 0.007511243 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142230 E001 0.0000000       19 47113274 47113353 80 +      
ENSG00000142230 E002 1.4842693 0.0106019911 2.694704e-02 6.588333e-02 19 47113441 47113525 85 + 0.601 0.241 -2.014
ENSG00000142230 E003 0.0000000       19 47125096 47125330 235 +      
ENSG00000142230 E004 0.0000000       19 47130716 47130741 26 +      
ENSG00000142230 E005 0.3299976 0.0274424043 4.211192e-01   19 47130742 47130781 40 + 0.000 0.175 13.585
ENSG00000142230 E006 0.6287620 0.0180577636 5.466231e-01 6.767753e-01 19 47130782 47130786 5 + 0.268 0.175 -0.790
ENSG00000142230 E007 1.1834270 0.0119439930 6.802860e-01 7.842070e-01 19 47130787 47130789 3 + 0.359 0.299 -0.373
ENSG00000142230 E008 2.6183890 0.0914029398 5.716620e-01 6.978970e-01 19 47130790 47130796 7 + 0.602 0.508 -0.433
ENSG00000142230 E009 9.8354147 0.0017581452 9.471339e-01 9.707924e-01 19 47130797 47130828 32 + 0.999 1.017 0.067
ENSG00000142230 E010 9.6871215 0.0018160574 8.726478e-01 9.220844e-01 19 47130829 47130829 1 + 0.999 1.007 0.028
ENSG00000142230 E011 11.1952475 0.0016187698 8.857198e-01 9.309176e-01 19 47130830 47130834 5 + 1.035 1.075 0.147
ENSG00000142230 E012 24.3270253 0.0007651791 6.112198e-02 1.285198e-01 19 47130835 47130837 3 + 1.453 1.348 -0.364
ENSG00000142230 E013 99.7306087 0.0021358257 1.606444e-01 2.759666e-01 19 47130838 47130858 21 + 2.001 1.964 -0.125
ENSG00000142230 E014 35.9407379 0.0019141267 9.777465e-01 9.901728e-01 19 47130859 47130860 2 + 1.525 1.549 0.082
ENSG00000142230 E015 53.6602299 0.0012768268 4.361823e-01 5.782889e-01 19 47130861 47130865 5 + 1.666 1.734 0.230
ENSG00000142230 E016 196.0634714 0.0121538782 5.888716e-01 7.120168e-01 19 47130866 47130888 23 + 2.278 2.259 -0.064
ENSG00000142230 E017 221.1447156 0.0092306565 5.680440e-01 6.947605e-01 19 47130889 47130894 6 + 2.328 2.312 -0.053
ENSG00000142230 E018 1106.4882770 0.0028144118 1.144264e-01 2.120030e-01 19 47130895 47131028 134 + 3.034 3.007 -0.090
ENSG00000142230 E019 8.4423873 0.0021642278 1.528573e-01 2.655342e-01 19 47131029 47131112 84 + 1.035 0.899 -0.505
ENSG00000142230 E020 0.6235652 0.0193874923 1.103155e-01 2.060126e-01 19 47131250 47131320 71 + 0.359 0.096 -2.373
ENSG00000142230 E021 0.5149111 0.0203698954 9.762744e-01 9.891712e-01 19 47135528 47135605 78 + 0.155 0.175 0.212
ENSG00000142230 E022 1.2920680 0.0102496674 1.217484e-01 2.224214e-01 19 47142511 47142611 101 + 0.497 0.241 -1.525
ENSG00000142230 E023 1639.7687826 0.0013697120 2.790034e-03 9.644654e-03 19 47143494 47143605 112 + 3.214 3.174 -0.130
ENSG00000142230 E024 2264.7362795 0.0009472728 1.096814e-03 4.293408e-03 19 47150202 47150375 174 + 3.349 3.317 -0.107
ENSG00000142230 E025 1.1876934 0.1860822489 8.014802e-01 8.735124e-01 19 47151996 47152053 58 + 0.359 0.300 -0.371
ENSG00000142230 E026 2216.6842153 0.0005204566 1.097595e-05 7.224770e-05 19 47152898 47153040 143 + 3.342 3.308 -0.114
ENSG00000142230 E027 1872.9381125 0.0003329325 3.997356e-06 2.908727e-05 19 47155114 47155213 100 + 3.268 3.237 -0.102
ENSG00000142230 E028 0.6633060 0.0192194130 1.108770e-01 2.068400e-01 19 47156569 47156661 93 + 0.359 0.096 -2.372
ENSG00000142230 E029 0.9222279 0.0131548795 4.595489e-01 5.996581e-01 19 47156987 47157181 195 + 0.359 0.241 -0.791
ENSG00000142230 E030 809.5606280 0.0001196763 8.299116e-03 2.454175e-02 19 47169818 47169820 3 + 2.892 2.883 -0.030
ENSG00000142230 E031 1696.3008333 0.0001300059 3.719401e-02 8.583829e-02 19 47169821 47169923 103 + 3.203 3.208 0.018
ENSG00000142230 E032 20.5918692 0.0009911439 7.464984e-03 2.242407e-02 19 47180146 47180303 158 + 1.426 1.251 -0.609
ENSG00000142230 E033 1947.1092961 0.0001265629 4.133816e-01 5.568826e-01 19 47197233 47197377 145 + 3.254 3.273 0.063
ENSG00000142230 E034 1602.9958783 0.0001768482 9.193732e-02 1.781287e-01 19 47203671 47203740 70 + 3.151 3.196 0.150
ENSG00000142230 E035 7.6442800 0.0032369592 7.469855e-02 1.510564e-01 19 47205062 47205103 42 + 1.035 0.856 -0.671
ENSG00000142230 E036 75.4844753 0.0003938659 1.635395e-01 2.797376e-01 19 47205104 47205129 26 + 1.802 1.892 0.300
ENSG00000142230 E037 7123.5466909 0.0022860006 1.714970e-06 1.353563e-05 19 47209159 47210636 1478 + 3.750 3.856 0.350