ENSG00000142197

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399151 ENSG00000142197 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1B protein_coding protein_coding 3.010669 2.923538 2.970813 0.2396737 0.2076766 0.02306452 0.1517588 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.05699583 0.00000000 0.00000000 0.0000000   3.894948e-06 FALSE TRUE
ENST00000492760 ENSG00000142197 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1B protein_coding processed_transcript 3.010669 2.923538 2.970813 0.2396737 0.2076766 0.02306452 0.1643106 0.0000000 0.5302468 0.00000000 0.17555914 5.7555468 0.04956667 0.00000000 0.17210000 0.1721000 3.894948e-06 3.894948e-06 FALSE FALSE
ENST00000691173 ENSG00000142197 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1B protein_coding protein_coding 3.010669 2.923538 2.970813 0.2396737 0.2076766 0.02306452 2.4505134 2.7067184 2.2903637 0.19957173 0.07885774 -0.2400030 0.80952500 0.92720000 0.77903333 -0.1481667 9.388596e-02 3.894948e-06 FALSE TRUE
ENST00000693273 ENSG00000142197 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1B protein_coding nonsense_mediated_decay 3.010669 2.923538 2.970813 0.2396737 0.2076766 0.02306452 0.1967019 0.1610961 0.1318776 0.07961579 0.07852137 -0.2701603 0.06691667 0.05143333 0.04263333 -0.0088000 8.875814e-01 3.894948e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142197 E001 2.2338637 0.1410823256 2.526620e-01 3.890506e-01 21 36156782 36156823 42 + 0.639 0.385 -1.231
ENSG00000142197 E002 8.0620016 0.0021951881 2.653364e-01 4.033799e-01 21 36156824 36156937 114 + 1.014 0.893 -0.454
ENSG00000142197 E003 5.8811434 0.0037458539 6.147699e-01 7.331704e-01 21 36156938 36156943 6 + 0.866 0.805 -0.235
ENSG00000142197 E004 0.0000000       21 36164535 36164593 59 +      
ENSG00000142197 E005 11.9047084 0.0014585544 1.869481e-02 4.866544e-02 21 36164708 36164835 128 + 1.222 1.003 -0.788
ENSG00000142197 E006 7.4745102 0.0053846681 8.301854e-04 3.367076e-03 21 36164836 36164871 36 + 1.112 0.721 -1.489
ENSG00000142197 E007 13.0088587 0.0013343006 5.432751e-04 2.321954e-03 21 36199070 36199251 182 + 1.302 0.991 -1.114
ENSG00000142197 E008 12.0484552 0.0352296535 1.429950e-01 2.521207e-01 21 36200331 36200501 171 + 1.202 1.021 -0.652
ENSG00000142197 E009 17.9907777 0.0246777261 4.014086e-03 1.318132e-02 21 36208715 36208904 190 + 1.427 1.115 -1.098
ENSG00000142197 E010 12.0031786 0.0216910770 4.619509e-02 1.023953e-01 21 36211553 36211651 99 + 1.222 0.994 -0.824
ENSG00000142197 E011 14.9462677 0.0337327576 1.294337e-01 2.333739e-01 21 36211974 36212097 124 + 1.294 1.105 -0.671
ENSG00000142197 E012 15.0562236 0.0053953639 1.300350e-03 4.977619e-03 21 36214081 36214190 110 + 1.348 1.061 -1.019
ENSG00000142197 E013 16.9342904 0.0014077707 2.183729e-03 7.792004e-03 21 36214442 36214556 115 + 1.376 1.130 -0.867
ENSG00000142197 E014 17.8586938 0.0013609515 5.490719e-03 1.726328e-02 21 36219372 36219492 121 + 1.383 1.165 -0.765
ENSG00000142197 E015 16.2186297 0.0011680475 2.230328e-02 5.630266e-02 21 36223231 36223350 120 + 1.325 1.139 -0.658
ENSG00000142197 E016 14.6337405 0.0047757146 1.614523e-03 6.006804e-03 21 36225565 36225667 103 + 1.326 1.040 -1.018
ENSG00000142197 E017 20.6441485 0.0010060658 2.170748e-03 7.752255e-03 21 36227686 36227877 192 + 1.439 1.213 -0.789
ENSG00000142197 E018 50.1194632 0.0110119551 3.606798e-03 1.202945e-02 21 36230450 36231134 685 + 1.799 1.609 -0.644
ENSG00000142197 E019 22.4150096 0.0127820363 4.118642e-02 9.322600e-02 21 36232804 36233075 272 + 1.451 1.279 -0.597
ENSG00000142197 E020 13.6521029 0.0022883035 2.098880e-03 7.530806e-03 21 36237262 36237414 153 + 1.302 1.027 -0.980
ENSG00000142197 E021 10.5592822 0.0017063219 4.752514e-02 1.047759e-01 21 36238601 36238701 101 + 1.159 0.965 -0.707
ENSG00000142197 E022 20.6730211 0.0009447857 7.016277e-01 8.007016e-01 21 36239765 36239955 191 + 1.333 1.308 -0.089
ENSG00000142197 E023 87.2788815 0.0118336426 1.121458e-01 2.086798e-01 21 36245048 36246300 1253 + 1.985 1.899 -0.290
ENSG00000142197 E024 33.5817671 0.0058603889 1.659455e-01 2.829158e-01 21 36246301 36246677 377 + 1.579 1.489 -0.307
ENSG00000142197 E025 23.7785822 0.0008892991 4.545088e-01 5.951432e-01 21 36247517 36247628 112 + 1.348 1.405 0.198
ENSG00000142197 E026 31.3315046 0.0272446292 3.823375e-01 5.265757e-01 21 36248380 36248568 189 + 1.438 1.528 0.309
ENSG00000142197 E027 24.2639784 0.0010175878 1.109291e-01 2.069173e-01 21 36251162 36251284 123 + 1.310 1.429 0.413
ENSG00000142197 E028 24.6394127 0.0007917884 6.675287e-01 7.747478e-01 21 36253772 36253909 138 + 1.376 1.410 0.117
ENSG00000142197 E029 14.0457701 0.0013664053 7.499531e-01 8.367622e-01 21 36260677 36260732 56 + 1.181 1.156 -0.089
ENSG00000142197 E030 0.2924217 0.0290785164 1.349337e-01   21 36260733 36261915 1183 + 0.242 0.000 -10.258
ENSG00000142197 E031 25.8009048 0.0008285307 9.517527e-01 9.737834e-01 21 36263546 36263650 105 + 1.415 1.414 -0.002
ENSG00000142197 E032 23.8873520 0.0049966179 6.841439e-01 7.871838e-01 21 36263748 36263814 67 + 1.402 1.375 -0.097
ENSG00000142197 E033 31.7289938 0.0015378443 1.276748e-01 2.309168e-01 21 36270013 36270157 145 + 1.439 1.541 0.349
ENSG00000142197 E034 22.4958705 0.0010282353 4.394061e-03 1.424782e-02 21 36277021 36277100 80 + 1.212 1.433 0.770
ENSG00000142197 E035 23.8641728 0.0064931512 3.670201e-02 8.490971e-02 21 36277975 36278084 110 + 1.268 1.442 0.606
ENSG00000142197 E036 29.1908835 0.0007526302 5.217902e-01 6.556647e-01 21 36278209 36278355 147 + 1.439 1.484 0.155
ENSG00000142197 E037 22.1853903 0.0028265483 5.710718e-01 6.974417e-01 21 36280285 36280346 62 + 1.376 1.337 -0.136
ENSG00000142197 E038 32.1805439 0.0009903163 9.591860e-02 1.842633e-01 21 36281483 36281611 129 + 1.439 1.548 0.373
ENSG00000142197 E039 43.1400515 0.0005577038 6.748050e-02 1.391605e-01 21 36288014 36288150 137 + 1.566 1.669 0.350
ENSG00000142197 E040 34.2803420 0.0114446305 2.647175e-02 6.489046e-02 21 36288756 36288811 56 + 1.416 1.595 0.616
ENSG00000142197 E041 52.4842877 0.0112783328 4.732467e-03 1.518498e-02 21 36289045 36289206 162 + 1.575 1.780 0.696
ENSG00000142197 E042 43.9839496 0.0052307238 1.816417e-04 8.850235e-04 21 36292104 36292233 130 + 1.468 1.716 0.846
ENSG00000142197 E043 120.5764202 0.0041556767 6.741511e-16 2.606979e-14 21 36293320 36294274 955 + 1.812 2.180 1.236