ENSG00000142192

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346798 ENSG00000142192 HEK293_OSMI2_2hA HEK293_TMG_2hB APP protein_coding protein_coding 182.5475 123.2921 225.9009 9.900407 3.871836 0.8735559 31.36352 42.582190 33.25627 4.290038 9.2830859 -0.3565287 0.20322917 0.3444667 0.1480667 -0.1964000 3.438645e-02 3.859378e-34 FALSE TRUE
ENST00000348990 ENSG00000142192 HEK293_OSMI2_2hA HEK293_TMG_2hB APP protein_coding protein_coding 182.5475 123.2921 225.9009 9.900407 3.871836 0.8735559 15.85345 2.304112 16.17873 2.304112 0.3444675 2.8064593 0.08449583 0.0174000 0.0717000 0.0543000 9.864712e-02 3.859378e-34 FALSE TRUE
ENST00000357903 ENSG00000142192 HEK293_OSMI2_2hA HEK293_TMG_2hB APP protein_coding protein_coding 182.5475 123.2921 225.9009 9.900407 3.871836 0.8735559 75.17781 60.890093 80.64344 6.673661 4.2749182 0.4052917 0.43048333 0.4913333 0.3568667 -0.1344667 5.151329e-04 3.859378e-34 FALSE TRUE
ENST00000439274 ENSG00000142192 HEK293_OSMI2_2hA HEK293_TMG_2hB APP protein_coding protein_coding 182.5475 123.2921 225.9009 9.900407 3.871836 0.8735559 26.87709 0.000000 47.75112 0.000000 8.6595810 12.2216211 0.12128750 0.0000000 0.2110000 0.2110000 3.859378e-34 3.859378e-34 FALSE TRUE
MSTRG.21180.6 ENSG00000142192 HEK293_OSMI2_2hA HEK293_TMG_2hB APP protein_coding   182.5475 123.2921 225.9009 9.900407 3.871836 0.8735559 24.41768 6.058288 38.33494 2.212823 4.3936544 2.6596749 0.11277083 0.0529000 0.1693333 0.1164333 3.157782e-02 3.859378e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142192 E001 0.8469850 1.369686e-02 7.708257e-02 1.548165e-01 21 25880550 25880550 1 - 0.102 0.415 2.597
ENSG00000142192 E002 1068.1562458 3.613832e-03 4.302663e-13 1.119679e-11 21 25880551 25881014 464 - 2.903 3.146 0.806
ENSG00000142192 E003 2339.9003370 2.693053e-03 3.303405e-16 1.331532e-14 21 25881015 25881330 316 - 3.256 3.476 0.732
ENSG00000142192 E004 815.7328576 3.694344e-03 5.260304e-06 3.724859e-05 21 25881331 25881331 1 - 2.832 2.992 0.530
ENSG00000142192 E005 1947.0096006 8.861178e-04 3.536121e-16 1.418094e-14 21 25881332 25881513 182 - 3.217 3.363 0.486
ENSG00000142192 E006 1335.1724787 8.583163e-05 1.355241e-20 9.299033e-19 21 25881514 25881609 96 - 3.071 3.188 0.386
ENSG00000142192 E007 1665.6215941 3.961658e-04 6.725528e-11 1.221251e-09 21 25881610 25881771 162 - 3.174 3.275 0.334
ENSG00000142192 E008 1786.0902978 1.125312e-04 7.275545e-11 1.313822e-09 21 25891722 25891868 147 - 3.215 3.296 0.269
ENSG00000142192 E009 1683.2908359 6.838719e-04 8.248447e-02 1.634274e-01 21 25897573 25897673 101 - 3.206 3.247 0.137
ENSG00000142192 E010 6.2448463 7.870817e-03 4.384324e-01 5.803095e-01 21 25897674 25897983 310 - 0.817 0.933 0.448
ENSG00000142192 E011 1328.3366652 1.809179e-03 1.865022e-01 3.093550e-01 21 25905024 25905077 54 - 3.129 3.113 -0.055
ENSG00000142192 E012 2158.8197580 3.549072e-04 7.617889e-04 3.121190e-03 21 25911741 25911962 222 - 3.343 3.321 -0.075
ENSG00000142192 E013 7.6023796 2.321793e-03 1.325282e-07 1.315332e-06 21 25945524 25945975 452 - 0.529 1.188 2.597
ENSG00000142192 E014 1196.3951161 3.902741e-04 1.198687e-01 2.197932e-01 21 25954590 25954689 100 - 3.080 3.076 -0.014
ENSG00000142192 E015 1259.4459312 3.804312e-04 3.191137e-02 7.568623e-02 21 25955627 25955755 129 - 3.106 3.095 -0.037
ENSG00000142192 E016 1166.4286902 4.432456e-04 3.475984e-01 4.918050e-01 21 25975070 25975189 120 - 3.065 3.070 0.014
ENSG00000142192 E017 761.1232553 1.517989e-03 2.895496e-01 4.302433e-01 21 25975190 25975219 30 - 2.885 2.877 -0.024
ENSG00000142192 E018 657.7162628 3.108218e-03 1.257384e-01 2.281989e-01 21 25975220 25975228 9 - 2.831 2.801 -0.099
ENSG00000142192 E019 1151.3404674 7.255639e-04 7.021833e-05 3.811539e-04 21 25975954 25976028 75 - 3.082 3.033 -0.165
ENSG00000142192 E020 1559.0382995 3.172514e-04 2.422457e-23 2.220257e-21 21 25982344 25982477 134 - 3.236 3.130 -0.352
ENSG00000142192 E021 8.5269629 2.325494e-03 7.806007e-04 3.189667e-03 21 25997188 25997359 172 - 0.761 1.153 1.472
ENSG00000142192 E022 438.3222973 8.623320e-04 9.229884e-11 1.638622e-09 21 25997360 25997416 57 - 2.695 2.566 -0.427
ENSG00000142192 E023 1637.5556784 7.954660e-05 7.060562e-13 1.775421e-11 21 26000015 26000182 168 - 3.236 3.186 -0.166
ENSG00000142192 E024 0.0000000       21 26009596 26009913 318 -      
ENSG00000142192 E025 1203.9473164 4.898658e-04 9.967510e-01 1.000000e+00 21 26021840 26021921 82 - 3.073 3.091 0.059
ENSG00000142192 E026 1613.3029060 2.476510e-04 1.911904e-01 3.152209e-01 21 26021922 26022042 121 - 3.207 3.210 0.011
ENSG00000142192 E027 1624.9866950 6.708289e-05 1.586180e-32 3.210439e-30 21 26051000 26051159 160 - 3.250 3.156 -0.314
ENSG00000142192 E028 794.7986443 1.836983e-04 1.574052e-11 3.173009e-10 21 26051160 26051193 34 - 2.932 2.855 -0.258
ENSG00000142192 E029 1075.6333631 8.326947e-04 2.189809e-08 2.534845e-07 21 26053236 26053348 113 - 3.066 2.982 -0.280
ENSG00000142192 E030 1.0393871 6.224108e-02 6.563681e-01 7.659757e-01 21 26053349 26053502 154 - 0.254 0.344 0.604
ENSG00000142192 E031 0.0000000       21 26068125 26068338 214 -      
ENSG00000142192 E032 1.1717988 1.559044e-01 1.851217e-01 3.076320e-01 21 26089511 26089942 432 - 0.184 0.477 1.918
ENSG00000142192 E033 1036.8685131 1.570911e-03 2.814914e-09 3.841776e-08 21 26089943 26090072 130 - 3.063 2.945 -0.393
ENSG00000142192 E034 477.1318542 1.676537e-03 1.168449e-09 1.709998e-08 21 26111979 26111984 6 - 2.736 2.591 -0.482
ENSG00000142192 E035 953.2837481 2.744225e-03 8.343370e-10 1.254565e-08 21 26111985 26112146 162 - 3.041 2.881 -0.532
ENSG00000142192 E036 0.1451727 4.409233e-02 6.960948e-01   21 26140153 26140460 308 - 0.102 0.000 -9.627
ENSG00000142192 E037 0.2214452 5.340270e-02 3.387768e-01   21 26169218 26169429 212 - 0.000 0.147 10.554
ENSG00000142192 E038 488.4823473 9.321543e-03 1.701960e-05 1.072447e-04 21 26170564 26170787 224 - 2.766 2.563 -0.676
ENSG00000142192 E039 0.5117019 2.303217e-02 4.132427e-02 9.347771e-02 21 26170985 26171128 144 - 0.000 0.342 12.132