ENSG00000142188

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420455 ENSG00000142188 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM50B protein_coding nonsense_mediated_decay 27.63776 15.68092 36.52952 3.910945 0.4166418 1.219528 3.4311724 3.6915821 4.4616931 1.1045097 0.6397079 0.27267915 0.14426667 0.23316667 0.121866667 -0.11130000 0.03409869 0.01238743 TRUE TRUE
ENST00000484377 ENSG00000142188 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM50B protein_coding processed_transcript 27.63776 15.68092 36.52952 3.910945 0.4166418 1.219528 1.1021684 1.1219178 1.0133196 0.1334971 0.1719433 -0.14551243 0.04937917 0.07770000 0.027666667 -0.05003333 0.01238743 0.01238743   FALSE
ENST00000542230 ENSG00000142188 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM50B protein_coding protein_coding 27.63776 15.68092 36.52952 3.910945 0.4166418 1.219528 14.5041379 6.0880261 20.8990131 2.3574394 0.6838189 1.77771075 0.46022500 0.36360000 0.572666667 0.20906667 0.03051861 0.01238743 FALSE TRUE
MSTRG.21266.11 ENSG00000142188 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM50B protein_coding   27.63776 15.68092 36.52952 3.910945 0.4166418 1.219528 3.7343981 0.8550434 5.6421661 0.4334889 0.9966877 2.70795945 0.12935000 0.05376667 0.154066667 0.10030000 0.37138102 0.01238743 FALSE TRUE
MSTRG.21266.4 ENSG00000142188 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM50B protein_coding   27.63776 15.68092 36.52952 3.910945 0.4166418 1.219528 2.1421256 1.6848855 1.7705211 0.5509040 0.3111036 0.07111173 0.10248333 0.10866667 0.048400000 -0.06026667 0.25186403 0.01238743   FALSE
MSTRG.21266.5 ENSG00000142188 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM50B protein_coding   27.63776 15.68092 36.52952 3.910945 0.4166418 1.219528 0.7937384 1.2450265 0.2669655 0.1810795 0.1607202 -2.17993963 0.04206667 0.09146667 0.007366667 -0.08410000 0.02518713 0.01238743 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142188 E001 1.3809388 0.4144793717 3.987072e-01 5.424453e-01 21 33432485 33432509 25 - 0.294 0.490 1.116
ENSG00000142188 E002 8.3172622 0.0033612545 6.231825e-03 1.922301e-02 21 33432510 33432540 31 - 0.813 1.126 1.168
ENSG00000142188 E003 63.9056614 0.0007879659 5.864605e-15 1.997540e-13 21 33432541 33432758 218 - 1.635 1.992 1.204
ENSG00000142188 E004 49.3469427 0.0127046879 8.335951e-06 5.639873e-05 21 33432759 33432797 39 - 1.547 1.856 1.048
ENSG00000142188 E005 33.3106516 0.0159993677 1.928911e-04 9.334483e-04 21 33432798 33432802 5 - 1.384 1.687 1.036
ENSG00000142188 E006 5.8355378 0.0220288929 1.511144e-02 4.073967e-02 21 33436883 33436883 1 - 0.662 0.994 1.301
ENSG00000142188 E007 11.1547795 0.0148690502 2.309359e-03 8.180804e-03 21 33436884 33436992 109 - 0.913 1.249 1.222
ENSG00000142188 E008 55.8117962 0.0218477889 9.147532e-05 4.819033e-04 21 33439214 33439297 84 - 1.592 1.915 1.094
ENSG00000142188 E009 6.3857249 0.0025863171 6.723174e-02 1.387532e-01 21 33447018 33447140 123 - 0.763 0.993 0.884
ENSG00000142188 E010 45.2334741 0.0081815254 9.526412e-08 9.709222e-07 21 33448782 33448879 98 - 1.484 1.846 1.232
ENSG00000142188 E011 22.9855299 0.0084703912 3.409237e-04 1.543976e-03 21 33448880 33448903 24 - 1.237 1.544 1.064
ENSG00000142188 E012 40.7887400 0.0074725720 6.682065e-04 2.782253e-03 21 33448904 33449140 237 - 1.510 1.753 0.827
ENSG00000142188 E013 61.5225588 0.0005139777 1.483194e-07 1.457475e-06 21 33449141 33449233 93 - 1.689 1.933 0.823
ENSG00000142188 E014 636.2884131 0.0043876125 2.266372e-01 3.583742e-01 21 33449234 33450520 1287 - 2.809 2.781 -0.094
ENSG00000142188 E015 59.3160796 0.0004496766 3.450058e-02 8.071466e-02 21 33450521 33450546 26 - 1.812 1.722 -0.307
ENSG00000142188 E016 184.9984598 0.0004347611 5.276493e-06 3.735206e-05 21 33450547 33450863 317 - 2.311 2.194 -0.393
ENSG00000142188 E017 1.4715057 0.1412060352 5.072856e-03 1.613007e-02 21 33453339 33453428 90 - 0.093 0.650 3.856
ENSG00000142188 E018 146.5894691 0.0002297044 5.167256e-07 4.557997e-06 21 33455727 33455784 58 - 2.219 2.075 -0.480
ENSG00000142188 E019 7.2354732 0.0109854243 7.908100e-01 8.662321e-01 21 33456004 33456097 94 - 0.926 0.905 -0.077
ENSG00000142188 E020 161.5770112 0.0005815985 3.501965e-04 1.580891e-03 21 33460413 33460505 93 - 2.247 2.149 -0.328
ENSG00000142188 E021 1.2543904 0.0106600529 9.157755e-01 9.507237e-01 21 33465018 33465341 324 - 0.342 0.367 0.148
ENSG00000142188 E022 110.5258332 0.0003288587 7.309388e-02 1.484807e-01 21 33465342 33465377 36 - 2.069 2.016 -0.175
ENSG00000142188 E023 118.0927677 0.0003191365 1.092198e-01 2.043955e-01 21 33465378 33465409 32 - 2.092 2.047 -0.151
ENSG00000142188 E024 190.9867736 0.0019053782 3.519336e-02 8.201136e-02 21 33467010 33467122 113 - 2.307 2.240 -0.224
ENSG00000142188 E025 1.2532576 0.0778911129 4.311821e-01 5.737609e-01 21 33467123 33467135 13 - 0.292 0.441 0.875
ENSG00000142188 E026 3.5223748 0.0479113998 2.219922e-01 3.527812e-01 21 33468420 33468786 367 - 0.725 0.505 -0.970
ENSG00000142188 E027 185.9645443 0.0049716469 5.166946e-02 1.121276e-01 21 33468787 33468926 140 - 2.301 2.206 -0.318
ENSG00000142188 E028 1.1792493 0.0731978342 7.645999e-01 8.476261e-01 21 33469531 33469683 153 - 0.342 0.277 -0.421
ENSG00000142188 E029 0.4031496 0.1021697896 8.136176e-02 1.616882e-01 21 33479109 33479289 181 - 0.000 0.277 10.433
ENSG00000142188 E030 88.3661710 0.0021323554 2.557224e-02 6.306329e-02 21 33479838 33479974 137 - 1.984 1.889 -0.317