ENSG00000142173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300527 ENSG00000142173 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A2 protein_coding protein_coding 23.13543 29.31785 18.31905 2.37519 0.6743989 -0.6781397 16.345010 19.306069 12.4421280 1.8068647 0.6611982 -0.6334092 0.70653333 0.65773333 0.678400000 0.02066667 0.8027310 0.010109 FALSE TRUE
MSTRG.21503.1 ENSG00000142173 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A2 protein_coding   23.13543 29.31785 18.31905 2.37519 0.6743989 -0.6781397 2.046155 2.929294 2.2839250 1.6252870 0.8001021 -0.3576515 0.09853333 0.10433333 0.127233333 0.02290000 0.8761227 0.010109 FALSE TRUE
MSTRG.21503.7 ENSG00000142173 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A2 protein_coding   23.13543 29.31785 18.31905 2.37519 0.6743989 -0.6781397 1.469475 1.635618 1.2219562 1.6356183 0.6508922 -0.4176787 0.05530000 0.04983333 0.065000000 0.01516667 0.5452677 0.010109 FALSE TRUE
MSTRG.21503.8 ENSG00000142173 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A2 protein_coding   23.13543 29.31785 18.31905 2.37519 0.6743989 -0.6781397 1.099944 2.868079 0.1006172 0.1845562 0.1006172 -4.7014581 0.04457083 0.10026667 0.005866667 -0.09440000 0.0101090 0.010109 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142173 E001 0.3634088 0.3465921101 4.922676e-01   21 46098076 46098111 36 + 0.001 0.177 8.519
ENSG00000142173 E002 0.8836184 0.0161316936 8.736655e-01 9.227995e-01 21 46098112 46098118 7 + 0.267 0.243 -0.184
ENSG00000142173 E003 56.3385144 0.0004574048 5.409052e-01 6.719577e-01 21 46098119 46098173 55 + 1.740 1.719 -0.072
ENSG00000142173 E004 0.1451727 0.0427111053 2.856726e-01   21 46098797 46099147 351 + 0.154 0.000 -12.799
ENSG00000142173 E005 73.0796724 0.0003790268 2.420589e-01 3.766268e-01 21 46111450 46111476 27 + 1.865 1.823 -0.140
ENSG00000142173 E006 124.3669859 0.0028594039 1.436164e-02 3.904944e-02 21 46111477 46111591 115 + 2.126 2.036 -0.302
ENSG00000142173 E007 286.2270256 0.0027867393 9.672583e-02 1.854698e-01 21 46111979 46112417 439 + 2.457 2.414 -0.142
ENSG00000142173 E008 193.6362068 0.0002716377 2.566361e-02 6.324662e-02 21 46112418 46112577 160 + 2.293 2.242 -0.169
ENSG00000142173 E009 117.6019301 0.0016482397 1.024174e-01 1.942054e-01 21 46112804 46112824 21 + 2.079 2.026 -0.177
ENSG00000142173 E010 1.8694228 0.0390205638 5.001035e-02 1.091926e-01 21 46112825 46112949 125 + 0.643 0.300 -1.771
ENSG00000142173 E011 4.4545024 0.0037724529 1.064358e-02 3.031578e-02 21 46113617 46114007 391 + 0.915 0.573 -1.399
ENSG00000142173 E012 162.4477636 0.0024013488 3.683374e-01 5.127557e-01 21 46114008 46114073 66 + 2.201 2.178 -0.075
ENSG00000142173 E013 163.2087124 0.0006718438 4.024264e-01 5.461599e-01 21 46115872 46115925 54 + 2.197 2.181 -0.055
ENSG00000142173 E014 146.9834020 0.0003603415 1.932090e-01 3.178099e-01 21 46116009 46116053 45 + 2.160 2.129 -0.105
ENSG00000142173 E015 126.5143662 0.0002587071 1.086867e-01 2.035928e-01 21 46116377 46116403 27 + 2.103 2.059 -0.147
ENSG00000142173 E016 137.0877147 0.0002557894 4.664122e-01 6.059449e-01 21 46116651 46116677 27 + 2.116 2.102 -0.048
ENSG00000142173 E017 147.3487941 0.0002726415 9.427397e-01 9.680384e-01 21 46116770 46116814 45 + 2.130 2.141 0.038
ENSG00000142173 E018 153.1622012 0.0030361332 8.028618e-01 8.744582e-01 21 46117400 46117453 54 + 2.141 2.163 0.073
ENSG00000142173 E019 0.9879930 0.0139650677 1.399659e-01 2.479787e-01 21 46117454 46117521 68 + 0.431 0.176 -1.769
ENSG00000142173 E020 140.9906808 0.0003344575 2.122183e-02 5.405815e-02 21 46117874 46117936 63 + 2.162 2.098 -0.212
ENSG00000142173 E021 131.4836517 0.0026585824 2.635820e-01 4.015021e-01 21 46118614 46118676 63 + 2.112 2.078 -0.112
ENSG00000142173 E022 144.7067765 0.0003440283 4.833018e-01 6.213275e-01 21 46119030 46119119 90 + 2.137 2.124 -0.043
ENSG00000142173 E023 104.0844611 0.0015023232 8.040273e-02 1.601907e-01 21 46119788 46119850 63 + 1.928 2.011 0.277
ENSG00000142173 E024 85.5035048 0.0060067225 5.619656e-01 6.896727e-01 21 46120515 46120559 45 + 1.870 1.917 0.157
ENSG00000142173 E025 67.3263088 0.0055634901 2.424849e-01 3.770822e-01 21 46120560 46120577 18 + 1.834 1.781 -0.179
ENSG00000142173 E026 104.8366998 0.0010845406 1.416458e-02 3.859728e-02 21 46121061 46121123 63 + 2.046 1.961 -0.283
ENSG00000142173 E027 122.8659020 0.0005424282 5.386840e-03 1.697868e-02 21 46121556 46121618 63 + 2.116 2.031 -0.287
ENSG00000142173 E028 106.0443084 0.0002877662 2.016429e-01 3.282269e-01 21 46122108 46122158 51 + 2.024 1.987 -0.124
ENSG00000142173 E029 110.1992760 0.0002735744 7.996529e-01 8.722300e-01 21 46122496 46122531 36 + 2.013 2.013 -0.001
ENSG00000142173 E030 128.4597054 0.0002587720 2.798542e-01 4.196290e-01 21 46122875 46122937 63 + 2.047 2.092 0.151
ENSG00000142173 E031 130.5118950 0.0002688339 7.171005e-01 8.125857e-01 21 46124651 46124713 63 + 2.071 2.092 0.070
ENSG00000142173 E032 129.8929871 0.0003796556 6.986326e-01 7.985440e-01 21 46124885 46124920 36 + 2.090 2.086 -0.013
ENSG00000142173 E033 131.4765581 0.0021761770 9.943367e-01 1.000000e+00 21 46125266 46125311 46 + 2.087 2.097 0.034
ENSG00000142173 E034 3.0390421 0.0883895304 8.168196e-01 8.841455e-01 21 46125417 46125464 48 + 0.550 0.602 0.236
ENSG00000142173 E035 248.5534774 0.0011189293 7.783118e-01 8.573487e-01 21 46125465 46125617 153 + 2.367 2.369 0.007
ENSG00000142173 E036 540.4964293 0.0007535547 1.485596e-02 4.016636e-02 21 46125785 46126237 453 + 2.662 2.721 0.196
ENSG00000142173 E037 170.7925110 0.0006001395 8.341293e-02 1.649099e-01 21 46126503 46126541 39 + 2.159 2.221 0.208
ENSG00000142173 E038 19.6435599 0.0039265950 6.279385e-01 7.436043e-01 21 46128903 46129195 293 + 1.304 1.272 -0.111
ENSG00000142173 E039 96.9179041 0.0003002915 3.323718e-02 7.826906e-02 21 46129196 46129808 613 + 1.894 1.986 0.307
ENSG00000142173 E040 465.4873951 0.0043938565 7.814725e-08 8.102707e-07 21 46131954 46132848 895 + 2.492 2.696 0.678