ENSG00000142156

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361866 ENSG00000142156 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A1 protein_coding protein_coding 50.66379 57.5165 44.56331 3.486613 0.1871708 -0.3680466 34.867267 39.772663 29.6839842 3.951899 0.06855118 -0.4219692 0.68931667 0.68993333 0.66613333 -0.0238000 0.864042984 0.002556699 FALSE TRUE
ENST00000498614 ENSG00000142156 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A1 protein_coding retained_intron 50.66379 57.5165 44.56331 3.486613 0.1871708 -0.3680466 3.797918 9.584471 0.7119419 3.108881 0.27721913 -3.7322488 0.06930000 0.16866667 0.01600000 -0.1526667 0.002556699 0.002556699 FALSE TRUE
MSTRG.21502.1 ENSG00000142156 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A1 protein_coding   50.66379 57.5165 44.56331 3.486613 0.1871708 -0.3680466 5.620919 3.961605 3.4982207 1.879775 2.32395405 -0.1789828 0.10874167 0.06546667 0.07806667 0.0126000 0.938388312 0.002556699 FALSE TRUE
MSTRG.21502.2 ENSG00000142156 HEK293_OSMI2_2hA HEK293_TMG_2hB COL6A1 protein_coding   50.66379 57.5165 44.56331 3.486613 0.1871708 -0.3680466 3.852032 2.961767 7.3680354 1.481160 1.81807687 1.3119157 0.08092083 0.05466667 0.16566667 0.1110000 0.553854085 0.002556699 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142156 E001 3.177381 0.0432401933 8.584152e-01 9.126449e-01 21 45981737 45981744 8 + 0.600 0.589 -0.047
ENSG00000142156 E002 40.092689 0.0048591884 2.208254e-02 5.584978e-02 21 45981745 45981769 25 + 1.666 1.542 -0.425
ENSG00000142156 E003 209.185198 0.0016660367 1.569429e-06 1.248944e-05 21 45981770 45981947 178 + 2.381 2.254 -0.426
ENSG00000142156 E004 325.482840 0.0001927030 3.073234e-20 2.015282e-18 21 45982634 45982763 130 + 2.593 2.427 -0.553
ENSG00000142156 E005 424.473605 0.0002148925 1.119324e-20 7.767492e-19 21 45984269 45984469 201 + 2.698 2.551 -0.492
ENSG00000142156 E006 444.907321 0.0001344063 2.797754e-12 6.384319e-11 21 45986526 45986685 160 + 2.692 2.592 -0.332
ENSG00000142156 E007 479.520465 0.0001302367 2.869143e-09 3.908748e-08 21 45986944 45987072 129 + 2.713 2.635 -0.259
ENSG00000142156 E008 1.477927 0.0236717977 8.506817e-02 1.675129e-01 21 45987109 45987154 46 + 0.557 0.267 -1.615
ENSG00000142156 E009 254.112814 0.0009707766 2.044070e-02 5.241796e-02 21 45987155 45987175 21 + 2.417 2.377 -0.131
ENSG00000142156 E010 4.208279 0.0184421558 4.287651e-02 9.631620e-02 21 45987176 45987498 323 + 0.865 0.584 -1.157
ENSG00000142156 E011 246.903045 0.0002276246 5.261729e-03 1.664333e-02 21 45987499 45987519 21 + 2.406 2.362 -0.147
ENSG00000142156 E012 297.052700 0.0015390947 2.789937e-01 4.186894e-01 21 45987610 45987654 45 + 2.464 2.458 -0.021
ENSG00000142156 E013 290.950736 0.0042396464 1.169201e-01 2.155671e-01 21 45989084 45989137 54 + 2.472 2.439 -0.109
ENSG00000142156 E014 291.859020 0.0039631169 1.787644e-01 2.996053e-01 21 45989608 45989652 45 + 2.469 2.445 -0.081
ENSG00000142156 E015 264.956814 0.0049681697 9.954560e-02 1.897875e-01 21 45989752 45989778 27 + 2.436 2.396 -0.135
ENSG00000142156 E016 243.014940 0.0003704747 6.750507e-03 2.057605e-02 21 45990258 45990284 27 + 2.399 2.355 -0.147
ENSG00000142156 E017 244.468547 0.0002214955 3.850894e-06 2.812304e-05 21 45990378 45990422 45 + 2.426 2.339 -0.290
ENSG00000142156 E018 237.692332 0.0001808336 4.115524e-04 1.818735e-03 21 45990773 45990826 54 + 2.400 2.338 -0.207
ENSG00000142156 E019 268.215664 0.0001682492 7.301254e-04 3.007416e-03 21 45990979 45991041 63 + 2.446 2.392 -0.179
ENSG00000142156 E020 292.968080 0.0008600124 3.471254e-01 4.913065e-01 21 45992010 45992072 63 + 2.454 2.453 -0.002
ENSG00000142156 E021 264.305584 0.0001929952 7.152757e-01 8.112238e-01 21 45992164 45992217 54 + 2.388 2.418 0.101
ENSG00000142156 E022 233.931486 0.0008810204 7.698796e-01 8.514184e-01 21 45992363 45992398 36 + 2.334 2.365 0.105
ENSG00000142156 E023 279.721990 0.0002143826 9.072600e-01 9.450995e-01 21 45992748 45992810 63 + 2.419 2.439 0.065
ENSG00000142156 E024 1.792205 0.1561748415 1.211832e-01 2.216239e-01 21 45994057 45994166 110 + 0.598 0.273 -1.763
ENSG00000142156 E025 285.377707 0.0002814481 2.193507e-01 3.495863e-01 21 45994167 45994229 63 + 2.410 2.460 0.166
ENSG00000142156 E026 282.180421 0.0002188120 5.598220e-01 6.879064e-01 21 45997421 45997483 63 + 2.414 2.449 0.117
ENSG00000142156 E027 249.845728 0.0001808075 6.864141e-02 1.411122e-01 21 45997700 45997762 63 + 2.341 2.406 0.217
ENSG00000142156 E028 265.385427 0.0002098257 9.073302e-03 2.646268e-02 21 45998121 45998171 51 + 2.357 2.439 0.275
ENSG00000142156 E029 251.300190 0.0003530266 6.112124e-02 1.285197e-01 21 45998398 45998433 36 + 2.342 2.410 0.227
ENSG00000142156 E030 9.615481 0.0362737733 7.087450e-01 8.063216e-01 21 45998434 45998552 119 + 1.028 0.996 -0.117
ENSG00000142156 E031 312.688524 0.0001783108 8.440131e-02 1.664506e-01 21 45998897 45998959 63 + 2.443 2.502 0.195
ENSG00000142156 E032 327.016190 0.0012554805 6.580515e-01 7.672691e-01 21 45999153 45999218 66 + 2.479 2.515 0.119
ENSG00000142156 E033 2.398165 0.0061697733 5.926625e-02 1.253832e-01 21 45999400 45999656 257 + 0.674 0.384 -1.387
ENSG00000142156 E034 254.131565 0.0028000811 9.670131e-01 9.833216e-01 21 45999657 45999692 36 + 2.375 2.403 0.092
ENSG00000142156 E035 235.425137 0.0039968776 7.249065e-01 8.182961e-01 21 46000331 46000367 37 + 2.351 2.365 0.047
ENSG00000142156 E036 154.737078 0.0002219001 1.007736e-01 1.916389e-01 21 46000759 46000767 9 + 2.192 2.165 -0.088
ENSG00000142156 E037 11.393135 0.0744902827 6.345197e-02 1.324468e-01 21 46000768 46000928 161 + 1.232 0.943 -1.050
ENSG00000142156 E038 10.116599 0.0254234185 7.614883e-04 3.120453e-03 21 46000931 46001151 221 + 1.231 0.827 -1.486
ENSG00000142156 E039 3.035460 0.0060440535 7.003881e-02 1.434293e-01 21 46001197 46001252 56 + 0.738 0.476 -1.165
ENSG00000142156 E040 270.028154 0.0009037682 5.265592e-01 6.597731e-01 21 46001253 46001304 52 + 2.412 2.419 0.023
ENSG00000142156 E041 346.720729 0.0004324829 2.827820e-01 4.228271e-01 21 46001305 46001386 82 + 2.524 2.524 -0.001
ENSG00000142156 E042 411.418225 0.0001588814 6.383163e-01 7.519641e-01 21 46001961 46002070 110 + 2.580 2.611 0.103
ENSG00000142156 E043 537.822476 0.0001242341 6.391350e-02 1.332111e-01 21 46002218 46002401 184 + 2.684 2.736 0.173
ENSG00000142156 E044 2.744071 0.0079076742 6.652213e-02 1.375900e-01 21 46002489 46002526 38 + 0.707 0.433 -1.261
ENSG00000142156 E045 541.760305 0.0008484870 4.473450e-01 5.887535e-01 21 46002527 46002710 184 + 2.696 2.736 0.133
ENSG00000142156 E046 283.478370 0.0026408407 2.301310e-01 3.626275e-01 21 46003120 46003149 30 + 2.400 2.465 0.215
ENSG00000142156 E047 831.553484 0.0015316739 3.562755e-04 1.604472e-03 21 46003391 46003857 467 + 2.838 2.945 0.356
ENSG00000142156 E048 384.235559 0.0019886222 9.916346e-03 2.855526e-02 21 46003858 46003998 141 + 2.508 2.607 0.332
ENSG00000142156 E049 821.885555 0.0027916160 1.972955e-08 2.303243e-07 21 46003999 46004575 577 + 2.780 2.966 0.616
ENSG00000142156 E050 791.837465 0.0092310567 2.550380e-07 2.394854e-06 21 46004576 46005050 475 + 2.701 2.974 0.910