ENSG00000142082

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382743 ENSG00000142082 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT3 protein_coding protein_coding 22.55469 34.79917 14.61524 1.649881 0.4320821 -1.251007 4.338611 6.291932 2.3733320 0.5541393 0.07941054 -1.4028143 0.19312083 0.18023333 0.16260000 -0.017633333 0.706074707 5.206728e-06 FALSE  
ENST00000524564 ENSG00000142082 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT3 protein_coding protein_coding 22.55469 34.79917 14.61524 1.649881 0.4320821 -1.251007 1.383585 1.881791 0.9225162 0.1789917 0.30392272 -1.0205524 0.05869583 0.05480000 0.06296667 0.008166667 0.948457277 5.206728e-06 FALSE  
ENST00000525776 ENSG00000142082 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT3 protein_coding protein_coding 22.55469 34.79917 14.61524 1.649881 0.4320821 -1.251007 2.282030 1.980986 1.7873053 0.2419599 0.22539049 -0.1476478 0.11292500 0.05676667 0.12156667 0.064800000 0.001277161 5.206728e-06    
ENST00000532837 ENSG00000142082 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT3 protein_coding nonsense_mediated_decay 22.55469 34.79917 14.61524 1.649881 0.4320821 -1.251007 10.048026 16.274544 6.4217624 2.2604068 0.06427005 -1.3402173 0.43613333 0.47123333 0.44006667 -0.031166667 0.904430063 5.206728e-06 FALSE  
MSTRG.4878.7 ENSG00000142082 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT3 protein_coding   22.55469 34.79917 14.61524 1.649881 0.4320821 -1.251007 1.697186 2.868767 1.3329499 0.7924979 0.37546907 -1.1000455 0.07534583 0.08256667 0.09140000 0.008833333 0.953280683 5.206728e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142082 E001 103.4304139 0.0003483421 2.693792e-01 0.4078959008 11 215030 216144 1115 - 1.963 1.920 -0.146
ENSG00000142082 E002 39.7675624 0.0032666578 9.694889e-01 0.9849139924 11 216145 216178 34 - 1.516 1.519 0.011
ENSG00000142082 E003 49.4169326 0.0006360963 4.146592e-01 0.5580604380 11 216179 216205 27 - 1.651 1.604 -0.158
ENSG00000142082 E004 202.0341209 0.0020570578 5.383644e-01 0.6697894247 11 216206 216390 185 - 2.204 2.228 0.079
ENSG00000142082 E005 256.6308220 0.0040302558 3.645015e-01 0.5088478999 11 216391 216524 134 - 2.295 2.333 0.126
ENSG00000142082 E006 201.1092441 0.0032642711 3.957541e-01 0.5395463612 11 216525 216610 86 - 2.193 2.227 0.115
ENSG00000142082 E007 194.9111954 0.0002336314 4.592196e-02 0.1018948035 11 216611 216718 108 - 2.155 2.216 0.205
ENSG00000142082 E008 25.6638877 0.0272979717 9.900341e-01 0.9978569972 11 218778 218831 54 - 1.342 1.349 0.024
ENSG00000142082 E009 229.4477829 0.0001758844 2.109034e-01 0.3396092265 11 218832 219041 210 - 2.247 2.282 0.117
ENSG00000142082 E010 3.4350348 0.3320583508 1.463214e-01 0.2566657445 11 222379 223849 1471 - 0.858 0.461 -1.716
ENSG00000142082 E011 0.6255398 0.0187557123 1.000000e+00 1.0000000000 11 224066 224077 12 - 0.195 0.193 -0.024
ENSG00000142082 E012 79.0595833 0.0003375346 5.074955e-01 0.6429928416 11 224078 224089 12 - 1.791 1.823 0.108
ENSG00000142082 E013 119.2243340 0.0002601721 3.928864e-01 0.5367787858 11 224090 224166 77 - 1.966 1.999 0.113
ENSG00000142082 E014 97.6695027 0.0003532649 8.882966e-01 0.9325826869 11 224167 224221 55 - 1.903 1.909 0.023
ENSG00000142082 E015 72.8304337 0.0005585098 5.557885e-01 0.6846019311 11 224222 224239 18 - 1.803 1.775 -0.093
ENSG00000142082 E016 0.1482932 0.0415051042 1.000000e+00   11 225673 225761 89 - 0.001 0.074 6.947
ENSG00000142082 E017 1.0768638 0.0490561512 3.077268e-01 0.4499639949 11 225762 226081 320 - 0.432 0.241 -1.204
ENSG00000142082 E018 134.0879364 0.0033634254 4.978263e-01 0.6343608745 11 230452 230552 101 - 2.063 2.035 -0.095
ENSG00000142082 E019 4.6351444 0.0042635826 1.621656e-01 0.2779271667 11 230553 230602 50 - 0.825 0.620 -0.840
ENSG00000142082 E020 3.8352871 0.0076599499 2.351424e-01 0.3685165612 11 230603 230641 39 - 0.744 0.558 -0.797
ENSG00000142082 E021 3.8342535 0.0158580045 9.214141e-01 0.9544018562 11 230642 230706 65 - 0.584 0.602 0.080
ENSG00000142082 E022 210.2763229 0.0010718008 1.844690e-01 0.3068118450 11 232983 233191 209 - 2.266 2.226 -0.133
ENSG00000142082 E023 90.7281231 0.0003044466 7.692317e-01 0.8509204823 11 233192 233208 17 - 1.864 1.878 0.045
ENSG00000142082 E024 81.4586672 0.0003819580 9.498907e-01 0.9726601766 11 233209 233215 7 - 1.825 1.829 0.012
ENSG00000142082 E025 134.1547305 0.0002349959 6.671347e-01 0.7744613332 11 233343 233437 95 - 2.030 2.046 0.054
ENSG00000142082 E026 95.6705996 0.0010298077 7.221982e-01 0.8163723002 11 233438 233486 49 - 1.909 1.895 -0.048
ENSG00000142082 E027 83.4503990 0.0003942114 1.970502e-01 0.3225297728 11 233487 233534 48 - 1.884 1.827 -0.190
ENSG00000142082 E028 12.3777575 0.0016606807 3.516469e-05 0.0002055174 11 233535 233683 149 - 1.320 0.918 -1.450
ENSG00000142082 E029 10.0655711 0.0017517338 7.488628e-04 0.0030745019 11 233911 234004 94 - 1.213 0.855 -1.316
ENSG00000142082 E030 92.8828897 0.0120749810 8.817249e-01 0.9282096425 11 236048 236193 146 - 1.887 1.883 -0.014
ENSG00000142082 E031 83.4025945 0.0104988487 7.801495e-01 0.8586857133 11 236194 236354 161 - 1.847 1.833 -0.047
ENSG00000142082 E032 7.8406650 0.0028629795 6.999824e-02 0.1433694386 11 236616 236931 316 - 1.027 0.807 -0.835