ENSG00000142002

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262960 ENSG00000142002 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP9 protein_coding protein_coding 43.05561 64.32933 27.42666 5.381903 0.9650143 -1.229596 29.999002 44.562679 19.698223 3.3912444 0.43924635 -1.177362 0.69639167 0.6937333 0.719266667 0.02553333 0.692452695 0.005254769 FALSE  
ENST00000594671 ENSG00000142002 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP9 protein_coding protein_coding 43.05561 64.32933 27.42666 5.381903 0.9650143 -1.229596 1.586349 4.145107 0.174215 0.7311981 0.09410215 -4.495424 0.03017083 0.0637000 0.006566667 -0.05713333 0.005254769 0.005254769 FALSE  
ENST00000597849 ENSG00000142002 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP9 protein_coding protein_coding 43.05561 64.32933 27.42666 5.381903 0.9650143 -1.229596 5.770536 8.589824 3.390831 0.7340339 0.46919572 -1.338420 0.13325000 0.1336667 0.122800000 -0.01086667 0.809622349 0.005254769 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000142002 E001 0.5911836 0.0311933839 3.445134e-01 4.886066e-01 19 4675224 4675226 3 - 0.000 0.211 11.254
ENSG00000142002 E002 603.1363425 0.0072196854 8.397173e-10 1.261754e-08 19 4675227 4675763 537 - 2.483 2.778 0.982
ENSG00000142002 E003 954.2842344 0.0019587774 1.521502e-11 3.075587e-10 19 4675764 4676463 700 - 2.772 2.957 0.617
ENSG00000142002 E004 303.9020561 0.0013259969 1.524807e-03 5.717256e-03 19 4676464 4676563 100 - 2.333 2.443 0.365
ENSG00000142002 E005 180.5639274 0.0012939466 7.589010e-02 1.529305e-01 19 4676564 4676575 12 - 2.136 2.212 0.253
ENSG00000142002 E006 294.8505603 0.0024487688 1.419485e-01 2.506988e-01 19 4676576 4676656 81 - 2.359 2.424 0.216
ENSG00000142002 E007 168.8100766 0.0034418023 1.851245e-01 3.076320e-01 19 4679835 4679836 2 - 2.114 2.185 0.236
ENSG00000142002 E008 398.0955420 0.0015970367 5.748129e-01 7.005608e-01 19 4679837 4679946 110 - 2.516 2.546 0.101
ENSG00000142002 E009 462.5836987 0.0014463784 8.594688e-01 9.133446e-01 19 4682696 4682838 143 - 2.588 2.608 0.067
ENSG00000142002 E010 1.5574344 0.0206981430 8.439877e-03 2.488497e-02 19 4682944 4683189 246 - 0.659 0.211 -2.511
ENSG00000142002 E011 10.2095329 0.0055838878 2.938553e-01 4.349117e-01 19 4683190 4683324 135 - 1.067 0.961 -0.393
ENSG00000142002 E012 419.8189895 0.0002115125 9.037372e-01 9.427559e-01 19 4683477 4683629 153 - 2.550 2.560 0.035
ENSG00000142002 E013 334.5730777 0.0001896672 1.420720e-05 9.109257e-05 19 4684663 4684809 147 - 2.518 2.436 -0.273
ENSG00000142002 E014 9.9454285 0.0592261999 9.867906e-02 1.884749e-01 19 4684810 4684862 53 - 1.153 0.907 -0.905
ENSG00000142002 E015 40.0267619 0.0005278541 2.777798e-11 5.383035e-10 19 4684863 4685625 763 - 1.789 1.425 -1.239
ENSG00000142002 E016 129.6599005 0.0002470212 2.356023e-01 3.690889e-01 19 4685626 4685627 2 - 2.072 2.042 -0.098
ENSG00000142002 E017 286.6109474 0.0001716115 1.215038e-02 3.389138e-02 19 4685628 4685771 144 - 2.426 2.380 -0.156
ENSG00000142002 E018 20.6198076 0.0054963099 2.950545e-03 1.011824e-02 19 4688292 4688756 465 - 1.028 1.339 1.108
ENSG00000142002 E019 281.9350622 0.0001807751 9.709930e-01 9.858815e-01 19 4688757 4688892 136 - 2.375 2.387 0.039
ENSG00000142002 E020 218.3819041 0.0002102725 2.253609e-01 3.568445e-01 19 4689570 4689655 86 - 2.239 2.285 0.155
ENSG00000142002 E021 181.3573742 0.0002104647 7.061548e-01 8.043535e-01 19 4689656 4689683 28 - 2.195 2.196 0.004
ENSG00000142002 E022 213.6328428 0.0002648789 7.765737e-01 8.561194e-01 19 4689684 4689722 39 - 2.262 2.267 0.016
ENSG00000142002 E023 329.9710118 0.0002839915 4.337358e-01 5.761388e-01 19 4690878 4690957 80 - 2.459 2.454 -0.017
ENSG00000142002 E024 5.9280610 0.0038715988 1.218792e-03 4.703916e-03 19 4694317 4694317 1 - 0.305 0.873 2.668
ENSG00000142002 E025 108.0348885 0.0036597608 1.525334e-13 4.222855e-12 19 4694318 4694660 343 - 1.625 2.049 1.431
ENSG00000142002 E026 536.0106948 0.0018423653 8.189713e-01 8.856648e-01 19 4694661 4694823 163 - 2.662 2.671 0.030
ENSG00000142002 E027 0.0000000       19 4694824 4695094 271 -      
ENSG00000142002 E028 507.1407028 0.0013888008 9.630094e-01 9.806295e-01 19 4695378 4695555 178 - 2.633 2.647 0.045
ENSG00000142002 E029 390.4819229 0.0001799020 1.177649e-01 2.167387e-01 19 4697551 4697651 101 - 2.491 2.537 0.152
ENSG00000142002 E030 299.5210192 0.0001752385 2.380366e-01 3.718628e-01 19 4700216 4700273 58 - 2.381 2.422 0.136
ENSG00000142002 E031 180.6115343 0.0002002310 9.878261e-01 9.964559e-01 19 4700274 4700277 4 - 2.185 2.197 0.043
ENSG00000142002 E032 397.1238461 0.0001694988 8.084346e-01 8.783231e-01 19 4702027 4702155 129 - 2.530 2.537 0.025
ENSG00000142002 E033 301.3364814 0.0001710432 4.245523e-02 9.554520e-02 19 4702603 4702683 81 - 2.439 2.405 -0.115
ENSG00000142002 E034 206.1974677 0.0008862674 2.032790e-01 3.303079e-01 19 4702684 4702716 33 - 2.267 2.242 -0.084
ENSG00000142002 E035 382.4432023 0.0006107054 2.663117e-02 6.522722e-02 19 4703886 4704054 169 - 2.546 2.509 -0.122
ENSG00000142002 E036 328.0805383 0.0013375441 9.414363e-02 1.816099e-01 19 4704131 4704257 127 - 2.476 2.445 -0.102
ENSG00000142002 E037 202.4334557 0.0002050140 2.649113e-02 6.493292e-02 19 4704258 4704304 47 - 2.278 2.228 -0.166
ENSG00000142002 E038 150.0947460 0.0002103394 1.098669e-01 2.053570e-01 19 4705858 4705862 5 - 2.142 2.103 -0.132
ENSG00000142002 E039 185.1773838 0.0002145608 7.211913e-02 1.468639e-01 19 4705863 4705898 36 - 2.234 2.194 -0.135
ENSG00000142002 E040 171.9585049 0.0003663538 8.771156e-04 3.534038e-03 19 4705899 4705914 16 - 2.238 2.149 -0.296
ENSG00000142002 E041 162.9728648 0.0023287437 3.864979e-03 1.276270e-02 19 4705915 4705925 11 - 2.221 2.126 -0.316
ENSG00000142002 E042 223.9462941 0.0038988288 1.022400e-02 2.931730e-02 19 4705926 4705970 45 - 2.351 2.267 -0.281
ENSG00000142002 E043 212.0004275 0.0019653674 2.890042e-03 9.941348e-03 19 4714081 4714105 25 - 2.327 2.241 -0.287
ENSG00000142002 E044 234.0264421 0.0024219231 1.170222e-03 4.539861e-03 19 4714106 4714160 55 - 2.377 2.281 -0.320
ENSG00000142002 E045 155.5691468 0.0022783144 1.810259e-02 4.735217e-02 19 4714161 4714186 26 - 2.185 2.109 -0.252
ENSG00000142002 E046 123.3585994 0.0057167154 2.526540e-02 6.241789e-02 19 4714187 4714203 17 - 2.099 2.005 -0.315
ENSG00000142002 E047 145.3778897 0.0090115326 6.733530e-02 1.389246e-01 19 4714204 4714245 42 - 2.162 2.080 -0.273
ENSG00000142002 E048 198.7544209 0.0063993219 3.244601e-02 7.671130e-02 19 4714246 4714337 92 - 2.296 2.216 -0.268
ENSG00000142002 E049 0.5514428 0.0196331819 3.424065e-01 4.864048e-01 19 4715529 4715664 136 - 0.000 0.211 11.234
ENSG00000142002 E050 1.2856366 0.0115092191 5.865308e-01 7.100867e-01 19 4715665 4715726 62 - 0.402 0.310 -0.551
ENSG00000142002 E051 0.6568746 0.0210460936 8.903794e-01 9.339651e-01 19 4715727 4715889 163 - 0.178 0.211 0.297
ENSG00000142002 E052 0.5546650 0.0201806219 8.492204e-01 9.064204e-01 19 4715890 4716052 163 - 0.179 0.151 -0.285
ENSG00000142002 E053 0.5546650 0.0201806219 8.492204e-01 9.064204e-01 19 4716053 4716152 100 - 0.179 0.151 -0.285
ENSG00000142002 E054 0.9545924 0.0136968632 1.365295e-01 2.432252e-01 19 4717615 4717888 274 - 0.000 0.310 11.972
ENSG00000142002 E055 1.2532576 0.0649178423 2.355383e-01 3.690027e-01 19 4719203 4719324 122 - 0.482 0.262 -1.295
ENSG00000142002 E056 0.6621601 0.0165413015 3.708082e-01 5.152261e-01 19 4719618 4719850 233 - 0.305 0.151 -1.287
ENSG00000142002 E057 187.9671028 0.0024945106 1.553110e-02 4.169424e-02 19 4719851 4719922 72 - 2.265 2.192 -0.244
ENSG00000142002 E058 130.5268685 0.0006769930 2.976601e-02 7.150115e-02 19 4719923 4719941 19 - 2.101 2.036 -0.218
ENSG00000142002 E059 5.7391915 0.0029615694 5.657247e-02 1.207141e-01 19 4722195 4722304 110 - 0.936 0.696 -0.945
ENSG00000142002 E060 151.5721258 0.0021371783 1.670125e-02 4.427717e-02 19 4722499 4722551 53 - 2.174 2.098 -0.257
ENSG00000142002 E061 0.6255398 0.0209907162 8.907991e-01 9.342450e-01 19 4722552 4722656 105 - 0.179 0.210 0.295
ENSG00000142002 E062 0.1482932 0.0425256827 1.000000e+00   19 4722657 4722772 116 - 0.000 0.082 9.645
ENSG00000142002 E063 155.8396059 0.0045982072 3.696040e-02 8.539070e-02 19 4723674 4723842 169 - 2.186 2.111 -0.252
ENSG00000142002 E064 0.1451727 0.0432387539 1.917417e-01   19 4724407 4724532 126 - 0.178 0.000 -12.497
ENSG00000142002 E065 0.3729606 0.0306100696 5.025384e-01 6.385867e-01 19 4724634 4724673 40 - 0.179 0.082 -1.284