ENSG00000141985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269886 ENSG00000141985 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GL1 protein_coding protein_coding 120.6438 204.5581 78.52669 9.572049 2.337938 -1.381142 111.7534 190.6273457 68.707268 10.8819291 1.278144 -1.472086 0.92245833 0.930966667 0.8756333 -0.05533333 0.05049020 0.01122974 FALSE  
MSTRG.16210.5 ENSG00000141985 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GL1 protein_coding   120.6438 204.5581 78.52669 9.572049 2.337938 -1.381142 1.6792 0.7218761 6.400587 0.4905036 1.396359 3.130785 0.01959167 0.003533333 0.0806000 0.07706667 0.01122974 0.01122974 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141985 E001 8.8406825 2.874009e-02 1.189098e-02 3.327194e-02 19 4360370 4360370 1 - 0.567 1.006 1.764
ENSG00000141985 E002 4330.7008014 4.215128e-03 1.889899e-06 1.478667e-05 19 4360371 4361315 945 - 3.437 3.595 0.525
ENSG00000141985 E003 713.9318399 1.087802e-04 1.808839e-05 1.133461e-04 19 4361316 4361434 119 - 2.702 2.797 0.316
ENSG00000141985 E004 613.5123127 1.231225e-03 1.265300e-12 3.053207e-11 19 4361435 4361555 121 - 2.547 2.751 0.681
ENSG00000141985 E005 1857.1549477 6.155918e-04 1.320188e-04 6.676430e-04 19 4361556 4361796 241 - 3.127 3.211 0.281
ENSG00000141985 E006 1101.0882891 1.741943e-04 1.171107e-01 2.158249e-01 19 4362329 4362385 57 - 2.962 2.966 0.013
ENSG00000141985 E007 1456.3654054 1.406692e-04 5.358221e-01 6.676218e-01 19 4362612 4362736 125 - 3.073 3.091 0.059
ENSG00000141985 E008 1252.0540331 2.742554e-04 5.504996e-01 6.801214e-01 19 4363370 4363473 104 - 3.009 3.026 0.058
ENSG00000141985 E009 1244.1744662 1.250675e-04 6.937261e-02 1.423219e-01 19 4363720 4363821 102 - 3.018 3.020 0.007
ENSG00000141985 E010 734.8408809 1.948181e-04 5.271773e-04 2.261393e-03 19 4363822 4363852 31 - 2.815 2.783 -0.104
ENSG00000141985 E011 735.7777316 1.016937e-04 4.380028e-04 1.920617e-03 19 4363853 4363878 26 - 2.813 2.783 -0.099
ENSG00000141985 E012 807.7198377 1.145473e-04 5.087150e-04 2.192174e-03 19 4364088 4364120 33 - 2.851 2.824 -0.090
ENSG00000141985 E013 1085.9564314 1.199921e-04 7.472111e-05 4.028943e-04 19 4364121 4364221 101 - 2.980 2.953 -0.090
ENSG00000141985 E014 909.3904690 7.209268e-04 1.769068e-02 4.646872e-02 19 4365482 4365572 91 - 2.896 2.879 -0.057
ENSG00000141985 E015 820.3895637 3.375947e-04 1.375594e-04 6.928328e-04 19 4365573 4365625 53 - 2.866 2.829 -0.123
ENSG00000141985 E016 596.6469025 1.347723e-04 2.851522e-04 1.319457e-03 19 4366501 4366502 2 - 2.727 2.689 -0.126
ENSG00000141985 E017 874.4715350 9.989804e-05 1.081468e-08 1.325061e-07 19 4366503 4366570 68 - 2.907 2.851 -0.186
ENSG00000141985 E018 454.7987867 2.542646e-04 2.315047e-07 2.192674e-06 19 4366571 4366573 3 - 2.641 2.563 -0.261
ENSG00000141985 E019 738.7828346 1.416686e-03 1.407129e-07 1.389794e-06 19 4366926 4366994 69 - 2.864 2.770 -0.311
ENSG00000141985 E020 0.5483223 2.034550e-02 7.601266e-01 8.443143e-01 19 4380162 4380292 131 - 0.187 0.144 -0.448
ENSG00000141985 E021 5.3006390 6.375731e-03 2.002519e-01 3.265353e-01 19 4390052 4390610 559 - 0.840 0.677 -0.658
ENSG00000141985 E022 0.7414659 9.181742e-01 6.820234e-01 7.855847e-01 19 4395545 4396023 479 - 0.001 0.275 9.391
ENSG00000141985 E023 532.1587421 6.881863e-03 8.492036e-10 1.274795e-08 19 4400324 4400547 224 - 2.819 2.586 -0.775