ENSG00000141959

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349048 ENSG00000141959 HEK293_OSMI2_2hA HEK293_TMG_2hB PFKL protein_coding protein_coding 115.067 198.9177 70.84198 9.319213 1.352927 -1.489364 103.135 185.4131 59.91985 10.3114 1.518873 -1.629475 0.8781042 0.9313667 0.8456333 -0.08573333 0.003916407 2.172264e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141959 E001 2.219694 0.0133422159 2.675832e-02 6.548954e-02 21 44300048 44300048 1 + 0.697 0.327 -1.825
ENSG00000141959 E002 5.456436 0.0366888337 7.402205e-03 2.226514e-02 21 44300049 44300050 2 + 1.004 0.605 -1.588
ENSG00000141959 E003 7.660221 0.0946215024 3.828464e-02 8.788318e-02 21 44300051 44300052 2 + 1.092 0.753 -1.286
ENSG00000141959 E004 34.571524 0.0884274666 1.164480e-02 3.268692e-02 21 44300053 44300066 14 + 1.707 1.365 -1.172
ENSG00000141959 E005 142.784685 0.0264957482 1.891907e-03 6.889173e-03 21 44300067 44300095 29 + 2.249 2.005 -0.815
ENSG00000141959 E006 183.692375 0.0210711835 3.977636e-03 1.307976e-02 21 44300096 44300105 10 + 2.327 2.128 -0.663
ENSG00000141959 E007 401.708594 0.0143550253 3.724554e-02 8.594250e-02 21 44300106 44300190 85 + 2.601 2.492 -0.361
ENSG00000141959 E008 9.874200 0.0017073531 6.632782e-03 2.027038e-02 21 44304275 44304455 181 + 1.165 0.877 -1.061
ENSG00000141959 E009 3.681620 0.0044660019 9.501835e-01 9.728292e-01 21 44305194 44305256 63 + 0.584 0.601 0.073
ENSG00000141959 E010 8.333909 0.0021372098 7.558140e-04 3.100219e-03 21 44305257 44305417 161 + 1.148 0.768 -1.427
ENSG00000141959 E011 5.989606 0.0096193998 1.345041e-01 2.404109e-01 21 44305800 44305935 136 + 0.923 0.723 -0.783
ENSG00000141959 E012 551.853849 0.0083050602 2.542564e-02 6.275811e-02 21 44306681 44306754 74 + 2.726 2.634 -0.305
ENSG00000141959 E013 5.263919 0.0030535406 8.212004e-02 1.628671e-01 21 44307260 44307328 69 + 0.893 0.658 -0.942
ENSG00000141959 E014 6.434416 0.0319601562 3.370536e-05 1.979594e-04 21 44307964 44308111 148 + 1.166 0.583 -2.272
ENSG00000141959 E015 628.713564 0.0032750987 2.346792e-02 5.871767e-02 21 44311006 44311083 78 + 2.757 2.698 -0.197
ENSG00000141959 E016 1189.643777 0.0012714939 1.362026e-02 3.735530e-02 21 44312105 44312294 190 + 3.017 2.979 -0.127
ENSG00000141959 E017 1287.286626 0.0002830113 4.487366e-07 4.006589e-06 21 44312978 44313143 166 + 3.067 3.007 -0.198
ENSG00000141959 E018 582.704569 0.0009292584 1.534531e-06 1.223949e-05 21 44313638 44313646 9 + 2.753 2.656 -0.323
ENSG00000141959 E019 647.438290 0.0016846816 4.427841e-02 9.889662e-02 21 44313647 44313682 36 + 2.756 2.715 -0.137
ENSG00000141959 E020 1015.009167 0.0005995940 4.647031e-03 1.495111e-02 21 44313913 44314021 109 + 2.948 2.909 -0.129
ENSG00000141959 E021 77.587661 0.0143783492 6.708295e-31 1.201197e-28 21 44314022 44315526 1505 + 2.287 1.460 -2.791
ENSG00000141959 E022 41.613410 0.0005229003 3.993266e-37 1.147970e-34 21 44315527 44316243 717 + 1.966 1.277 -2.351
ENSG00000141959 E023 1058.934316 0.0007493613 7.779622e-01 8.571575e-01 21 44316244 44316339 96 + 2.932 2.937 0.019
ENSG00000141959 E024 1050.608486 0.0001510598 7.231058e-01 8.170180e-01 21 44316432 44316524 93 + 2.921 2.935 0.046
ENSG00000141959 E025 1145.888818 0.0002327898 2.804077e-01 4.202697e-01 21 44318470 44318595 126 + 2.949 2.974 0.083
ENSG00000141959 E026 934.401626 0.0001535908 3.012974e-01 4.430900e-01 21 44319351 44319411 61 + 2.861 2.886 0.081
ENSG00000141959 E027 500.933052 0.0001157094 9.965744e-01 1.000000e+00 21 44319412 44319415 4 + 2.604 2.612 0.028
ENSG00000141959 E028 36.917664 0.0458876152 5.528260e-10 8.597917e-09 21 44319416 44319622 207 + 1.926 1.212 -2.446
ENSG00000141959 E029 33.388660 0.0519196766 2.775867e-08 3.145778e-07 21 44319623 44319840 218 + 1.868 1.190 -2.328
ENSG00000141959 E030 8.695690 0.0033406609 2.919706e-11 5.634406e-10 21 44319841 44319866 26 + 1.343 0.621 -2.727
ENSG00000141959 E031 27.754442 0.0039578722 5.315382e-29 8.193516e-27 21 44319867 44320083 217 + 1.840 1.052 -2.730
ENSG00000141959 E032 504.190941 0.0001170071 8.083518e-01 8.782564e-01 21 44320084 44320086 3 + 2.611 2.614 0.012
ENSG00000141959 E033 846.676378 0.0001293887 5.644974e-01 6.917876e-01 21 44320087 44320147 61 + 2.839 2.839 0.000
ENSG00000141959 E034 17.132555 0.0010855452 8.838746e-14 2.533627e-12 21 44320148 44320576 429 + 1.565 0.964 -2.124
ENSG00000141959 E035 37.602843 0.0221054514 8.241826e-09 1.032051e-07 21 44320577 44321728 1152 + 1.844 1.321 -1.785
ENSG00000141959 E036 1226.845938 0.0014891087 4.409920e-01 5.826350e-01 21 44321729 44321875 147 + 2.980 3.008 0.093
ENSG00000141959 E037 860.365508 0.0015103909 3.553312e-02 8.267699e-02 21 44322133 44322203 71 + 2.799 2.860 0.202
ENSG00000141959 E038 923.147977 0.0001305199 4.644240e-06 3.330699e-05 21 44322962 44323049 88 + 2.814 2.892 0.259
ENSG00000141959 E039 1462.961653 0.0001128001 7.434011e-02 1.504858e-01 21 44323766 44323918 153 + 3.052 3.082 0.101
ENSG00000141959 E040 8.971956 0.0021133951 1.230096e-01 2.242519e-01 21 44324420 44324490 71 + 1.050 0.877 -0.646
ENSG00000141959 E041 750.664092 0.0001118196 5.014357e-01 6.375878e-01 21 44324491 44324492 2 + 2.787 2.785 -0.007
ENSG00000141959 E042 1808.562124 0.0011821205 9.329989e-01 9.617843e-01 21 44324493 44324655 163 + 3.159 3.174 0.047
ENSG00000141959 E043 1302.812996 0.0017630924 2.338425e-01 3.669438e-01 21 44324856 44324917 62 + 2.996 3.037 0.135
ENSG00000141959 E044 38.443170 0.0032462546 2.910205e-24 2.970526e-22 21 44324918 44325152 235 + 1.906 1.285 -2.119
ENSG00000141959 E045 1521.536850 0.0023883643 1.375610e-02 3.766842e-02 21 44325153 44325264 112 + 3.035 3.111 0.254
ENSG00000141959 E046 48.295354 0.0029600002 1.009840e-12 2.477803e-11 21 44325265 44325427 163 + 1.884 1.482 -1.363
ENSG00000141959 E047 64.157297 0.0090038982 5.483715e-12 1.190686e-10 21 44325428 44325731 304 + 2.018 1.588 -1.452
ENSG00000141959 E048 83.897301 0.0049628094 2.182775e-18 1.152509e-16 21 44325732 44325960 229 + 2.145 1.699 -1.499
ENSG00000141959 E049 1348.313861 0.0008929428 1.175653e-08 1.431080e-07 21 44325961 44326060 100 + 2.948 3.066 0.392
ENSG00000141959 E050 1335.236514 0.0010580521 3.773034e-09 5.027005e-08 21 44326159 44326264 106 + 2.935 3.063 0.425
ENSG00000141959 E051 2469.827469 0.0027228163 1.329135e-15 4.949883e-14 21 44326715 44327376 662 + 3.125 3.345 0.729