ENSG00000141905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341919 ENSG00000141905 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIC protein_coding protein_coding 4.148856 5.241534 3.826667 0.6321891 0.2221577 -0.4528854 0.4132995 0.5615771 0.7094685 0.5615771 0.06686636 0.3319836 0.0887125 0.10073333 0.18596667 0.08523333 0.25462883 0.0001875554 FALSE TRUE
ENST00000395111 ENSG00000141905 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIC protein_coding protein_coding 4.148856 5.241534 3.826667 0.6321891 0.2221577 -0.4528854 0.7110637 1.1769722 0.9087639 0.5899993 0.07498164 -0.3695200 0.1841667 0.20193333 0.23930000 0.03736667 0.84696323 0.0001875554 FALSE TRUE
ENST00000586919 ENSG00000141905 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIC protein_coding protein_coding 4.148856 5.241534 3.826667 0.6321891 0.2221577 -0.4528854 0.9424567 0.2769908 1.5234206 0.2769908 0.17408721 2.4176770 0.2370250 0.04516667 0.39560000 0.35043333 0.03325609 0.0001875554 FALSE TRUE
ENST00000589123 ENSG00000141905 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIC protein_coding protein_coding 4.148856 5.241534 3.826667 0.6321891 0.2221577 -0.4528854 0.7113259 1.1284378 0.4981409 0.1166682 0.01249342 -1.1637549 0.1624625 0.21736667 0.13066667 -0.08670000 0.06383432 0.0001875554 FALSE TRUE
ENST00000589537 ENSG00000141905 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIC protein_coding retained_intron 4.148856 5.241534 3.826667 0.6321891 0.2221577 -0.4528854 0.3702436 0.6927675 0.1271426 0.1469134 0.03907860 -2.3573703 0.0856500 0.14110000 0.03446667 -0.10663333 0.06647748 0.0001875554 FALSE FALSE
ENST00000590282 ENSG00000141905 HEK293_OSMI2_2hA HEK293_TMG_2hB NFIC protein_coding protein_coding 4.148856 5.241534 3.826667 0.6321891 0.2221577 -0.4528854 0.7502903 1.0979774 0.0000000 0.5599073 0.00000000 -6.7917846 0.1766208 0.23156667 0.00000000 -0.23156667 0.19222220 0.0001875554 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141905 E001 0.0000000       19 3314403 3314856 454 +      
ENSG00000141905 E002 2.9088205 0.0053725567 5.556120e-01 6.844557e-01 19 3359563 3359646 84 + 0.595 0.547 -0.220
ENSG00000141905 E003 9.3123883 0.0022086556 1.527244e-01 2.653689e-01 19 3359647 3359682 36 + 1.044 0.946 -0.365
ENSG00000141905 E004 9.3123883 0.0022086556 1.527244e-01 2.653689e-01 19 3359683 3359685 3 + 1.044 0.946 -0.365
ENSG00000141905 E005 0.2987644 0.0290785164 7.579859e-02   19 3366549 3366582 34 + 0.265 0.000 -9.952
ENSG00000141905 E006 6.5570317 0.0025046969 3.816160e-01 5.259230e-01 19 3366583 3366666 84 + 0.888 0.833 -0.211
ENSG00000141905 E007 70.4216122 0.0010837952 3.180117e-04 1.452875e-03 19 3381712 3382243 532 + 1.882 1.787 -0.320
ENSG00000141905 E008 0.0000000       19 3410596 3411178 583 +      
ENSG00000141905 E009 29.6769663 0.0007168229 1.396120e-02 3.813468e-02 19 3425106 3425177 72 + 1.517 1.419 -0.339
ENSG00000141905 E010 33.0974465 0.0006975417 5.994344e-02 1.265121e-01 19 3433518 3433592 75 + 1.534 1.478 -0.192
ENSG00000141905 E011 44.8979071 0.0005289538 4.496048e-04 1.965213e-03 19 3434277 3434400 124 + 1.707 1.584 -0.420
ENSG00000141905 E012 5.7122353 0.0032557259 5.389127e-01 6.702685e-01 19 3435046 3435082 37 + 0.810 0.782 -0.112
ENSG00000141905 E013 53.5603294 0.0054413672 1.080765e-02 3.070372e-02 19 3435083 3435207 125 + 1.761 1.678 -0.281
ENSG00000141905 E014 50.6944051 0.0005004946 3.879202e-03 1.280431e-02 19 3449014 3449139 126 + 1.735 1.652 -0.280
ENSG00000141905 E015 43.0051689 0.0005170627 9.195888e-02 1.781650e-01 19 3452482 3452578 97 + 1.629 1.598 -0.106
ENSG00000141905 E016 35.5043535 0.0007775961 1.279081e-01 2.312512e-01 19 3452579 3452640 62 + 1.544 1.513 -0.107
ENSG00000141905 E017 24.0527509 0.0007966005 5.832454e-01 7.073923e-01 19 3452641 3452666 26 + 1.351 1.370 0.069
ENSG00000141905 E018 8.3199984 0.0021304472 4.600472e-01 6.001040e-01 19 3453763 3453916 154 + 0.838 0.981 0.545
ENSG00000141905 E019 0.7352249 0.6678433095 8.000073e-01 8.724778e-01 19 3453917 3454350 434 + 0.264 0.232 -0.243
ENSG00000141905 E020 19.2636371 0.0022675534 4.759672e-01 6.146469e-01 19 3456550 3456635 86 + 1.270 1.272 0.005
ENSG00000141905 E021 1.4402595 0.0178335696 9.566957e-01 9.768381e-01 19 3457883 3457989 107 + 0.354 0.400 0.261
ENSG00000141905 E022 610.8932969 0.0047570329 9.401462e-09 1.165780e-07 19 3462752 3469217 6466 + 2.633 2.810 0.591