ENSG00000141867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263377 ENSG00000141867 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD4 protein_coding protein_coding 28.49727 33.65777 25.45478 2.105876 0.5723249 -0.4028648 3.745712 9.92624042 0.000000 0.36886512 0.00000000 -9.9565563 0.1196958 0.2963000 0.0000000 -0.2963000 1.464545e-68 6.323618e-69 FALSE TRUE
ENST00000371835 ENSG00000141867 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD4 protein_coding protein_coding 28.49727 33.65777 25.45478 2.105876 0.5723249 -0.4028648 9.382898 15.35443632 5.001148 0.94206696 0.10532957 -1.6163819 0.3158917 0.4564000 0.1967333 -0.2596667 2.451966e-26 6.323618e-69 FALSE TRUE
ENST00000679869 ENSG00000141867 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD4 protein_coding protein_coding 28.49727 33.65777 25.45478 2.105876 0.5723249 -0.4028648 6.562158 5.92448868 6.836503 0.93135695 0.06034671 0.2062435 0.2293042 0.1750333 0.2687333 0.0937000 2.747624e-02 6.323618e-69 FALSE TRUE
MSTRG.16611.10 ENSG00000141867 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD4 protein_coding   28.49727 33.65777 25.45478 2.105876 0.5723249 -0.4028648 1.943440 0.00000000 3.597463 0.00000000 0.41119128 8.4948409 0.0767000 0.0000000 0.1409333 0.1409333 5.844617e-35 6.323618e-69 FALSE TRUE
MSTRG.16611.7 ENSG00000141867 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD4 protein_coding   28.49727 33.65777 25.45478 2.105876 0.5723249 -0.4028648 2.479661 0.02095915 5.323408 0.02095915 0.08668672 7.4285478 0.0969125 0.0006000 0.2092333 0.2086333 6.323618e-69 6.323618e-69 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141867 E001 568.9552497 0.0070107061 8.265904e-21 5.832219e-19 19 15235519 15237081 1563 - 2.404 2.844 1.467
ENSG00000141867 E002 233.6905374 0.0039934823 8.028084e-37 2.249847e-34 19 15237082 15237284 203 - 1.893 2.478 1.957
ENSG00000141867 E003 117.0567020 0.0087087940 7.750690e-09 9.752557e-08 19 15237285 15237350 66 - 1.772 2.151 1.271
ENSG00000141867 E004 138.2226490 0.0037150520 2.453366e-05 1.491362e-04 19 15237351 15237389 39 - 1.969 2.186 0.728
ENSG00000141867 E005 257.5321755 0.0030931340 3.788685e-10 6.066219e-09 19 15237390 15237566 177 - 2.206 2.465 0.864
ENSG00000141867 E006 184.9469536 0.0016468821 7.674113e-08 7.969727e-07 19 15237567 15237674 108 - 2.093 2.308 0.719
ENSG00000141867 E007 226.1570932 0.0018873330 1.639915e-07 1.598626e-06 19 15237675 15237890 216 - 2.189 2.392 0.678
ENSG00000141867 E008 424.6897083 0.0028612163 7.309837e-02 1.484862e-01 19 15237891 15238445 555 - 2.546 2.634 0.294
ENSG00000141867 E009 224.8125875 0.0014839189 6.614995e-01 7.699436e-01 19 15238743 15238980 238 - 2.317 2.333 0.054
ENSG00000141867 E010 279.1147977 0.0007445026 1.350948e-01 2.412232e-01 19 15239059 15239264 206 - 2.428 2.419 -0.030
ENSG00000141867 E011 226.8415166 0.0010166221 3.215801e-02 7.616250e-02 19 15239392 15239522 131 - 2.352 2.320 -0.106
ENSG00000141867 E012 169.9185031 0.0020502349 4.663817e-02 1.031879e-01 19 15239659 15239821 163 - 2.232 2.192 -0.135
ENSG00000141867 E013 109.9317197 0.0042445898 6.394811e-02 1.332700e-01 19 15239910 15240022 113 - 2.055 1.999 -0.186
ENSG00000141867 E014 66.7415506 0.0035364934 4.652394e-03 1.496455e-02 19 15242900 15243038 139 - 1.877 1.759 -0.398
ENSG00000141867 E015 2.8241275 0.0081991040 9.748443e-01 9.883351e-01 19 15243039 15243107 69 - 0.535 0.560 0.116
ENSG00000141867 E016 3.2075875 0.0048379145 1.563893e-02 4.193200e-02 19 15243108 15243221 114 - 0.796 0.453 -1.518
ENSG00000141867 E017 58.1380824 0.0010790683 2.399248e-02 5.979402e-02 19 15243222 15243487 266 - 1.798 1.715 -0.281
ENSG00000141867 E018 71.3448987 0.0003728700 1.158419e-03 4.499971e-03 19 15244231 15244522 292 - 1.904 1.793 -0.375
ENSG00000141867 E019 32.4792248 0.0143473184 2.348366e-02 5.874521e-02 19 15244523 15244600 78 - 1.604 1.445 -0.545
ENSG00000141867 E020 0.7665478 0.0197782430 5.790942e-02 1.230486e-01 19 15244601 15244709 109 - 0.418 0.101 -2.624
ENSG00000141867 E021 46.8820983 0.0007644834 3.973404e-04 1.764077e-03 19 15244710 15244762 53 - 1.757 1.600 -0.535
ENSG00000141867 E022 4.0338587 0.0055961113 3.100804e-01 4.524462e-01 19 15244763 15244998 236 - 0.767 0.644 -0.511
ENSG00000141867 E023 1.9208024 0.1056838879 6.500560e-01 7.611555e-01 19 15246508 15246618 111 - 0.480 0.414 -0.339
ENSG00000141867 E024 79.6862214 0.0265581315 1.896457e-04 9.197639e-04 19 15247047 15247276 230 - 1.600 1.989 1.315
ENSG00000141867 E025 768.8889737 0.0012327437 4.021381e-32 7.821751e-30 19 15247277 15248793 1517 - 2.663 2.944 0.934
ENSG00000141867 E026 83.7739733 0.0003600085 3.291587e-01 4.726643e-01 19 15248794 15248823 30 - 1.863 1.930 0.226
ENSG00000141867 E027 168.1365585 0.0002118796 4.117291e-02 9.320544e-02 19 15248824 15249004 181 - 2.145 2.232 0.291
ENSG00000141867 E028 88.3722221 0.0028923134 9.529778e-02 1.833291e-01 19 15249005 15249061 57 - 1.856 1.963 0.362
ENSG00000141867 E029 172.8971337 0.0026800639 3.837108e-03 1.268357e-02 19 15249062 15249290 229 - 2.121 2.260 0.465
ENSG00000141867 E030 12.4257546 0.0016736434 2.837040e-01 4.238578e-01 19 15252992 15253750 759 - 1.156 1.079 -0.277
ENSG00000141867 E031 2.9548049 0.0050665526 3.012941e-01 4.430900e-01 19 15253751 15253783 33 - 0.666 0.526 -0.625
ENSG00000141867 E032 8.9623225 0.0150318339 1.430207e-02 3.891484e-02 19 15253784 15254151 368 - 1.131 0.864 -0.989
ENSG00000141867 E033 208.3079892 0.0002076790 1.785357e-02 4.682103e-02 19 15254152 15254262 111 - 2.320 2.286 -0.110
ENSG00000141867 E034 362.6020417 0.0014133333 4.277030e-07 3.834692e-06 19 15255297 15255592 296 - 2.601 2.500 -0.335
ENSG00000141867 E035 118.6385686 0.0150207966 2.645539e-02 6.485957e-02 19 15256064 15256098 35 - 2.136 2.007 -0.432
ENSG00000141867 E036 103.5475788 0.0307735798 1.022681e-01 1.939727e-01 19 15256099 15256134 36 - 2.084 1.946 -0.463
ENSG00000141867 E037 124.4859470 0.0121163264 1.064619e-04 5.517560e-04 19 15256135 15256207 73 - 2.206 1.991 -0.722
ENSG00000141867 E038 116.4114981 0.0075631231 2.063400e-04 9.911635e-04 19 15256208 15256263 56 - 2.151 1.980 -0.573
ENSG00000141867 E039 252.9855342 0.0062480058 1.965066e-02 5.074091e-02 19 15256964 15257173 210 - 2.426 2.356 -0.233
ENSG00000141867 E040 1.5478668 0.0090233174 3.208719e-01 4.640452e-01 19 15257174 15258201 1028 - 0.257 0.452 1.182
ENSG00000141867 E041 2.9703443 0.0078776171 8.276385e-01 8.916477e-01 19 15258889 15259793 905 - 0.535 0.590 0.252
ENSG00000141867 E042 248.7015802 0.0006232507 3.919775e-14 1.180775e-12 19 15263420 15263548 129 - 2.471 2.309 -0.540
ENSG00000141867 E043 0.3332198 0.0295666121 7.174578e-01   19 15264118 15264403 286 - 0.147 0.101 -0.625
ENSG00000141867 E044 328.7319224 0.0001870033 8.611845e-30 1.421157e-27 19 15264404 15264766 363 - 2.614 2.413 -0.667
ENSG00000141867 E045 186.9258274 0.0009360183 3.411733e-09 4.582689e-08 19 15265354 15265626 273 - 2.341 2.195 -0.488
ENSG00000141867 E046 89.4664753 0.0023023700 1.236131e-06 1.006668e-05 19 15265627 15265643 17 - 2.045 1.862 -0.613
ENSG00000141867 E047 167.0677380 0.0031228735 7.771353e-09 9.776609e-08 19 15267416 15267513 98 - 2.315 2.125 -0.636
ENSG00000141867 E048 136.7552371 0.0124346608 3.585129e-04 1.612976e-03 19 15267514 15267551 38 - 2.226 2.043 -0.612
ENSG00000141867 E049 18.3062760 0.0225257303 4.135720e-02 9.354552e-02 19 15268154 15268240 87 - 1.381 1.193 -0.659
ENSG00000141867 E050 8.9886133 0.0018741908 6.654743e-04 2.772400e-03 19 15268241 15268281 41 - 1.169 0.830 -1.253
ENSG00000141867 E051 194.3764444 0.0054151885 1.562657e-10 2.667273e-09 19 15268905 15269012 108 - 2.411 2.165 -0.823
ENSG00000141867 E052 114.3836050 0.0003514098 3.728042e-18 1.912964e-16 19 15269013 15269042 30 - 2.191 1.926 -0.888
ENSG00000141867 E053 4.2168133 0.0066102490 8.660799e-04 3.494776e-03 19 15271322 15271392 71 - 0.939 0.491 -1.874
ENSG00000141867 E054 212.3570422 0.0010593302 6.779749e-23 5.954581e-21 19 15272815 15273133 319 - 2.452 2.200 -0.843
ENSG00000141867 E055 0.0000000       19 15275657 15275839 183 -      
ENSG00000141867 E056 0.1472490 0.0432815601 3.032967e-01   19 15280264 15280451 188 - 0.147 0.000 -9.183
ENSG00000141867 E057 3.3086486 0.0046625469 8.444499e-01 9.031853e-01 19 15331836 15331907 72 - 0.627 0.617 -0.040
ENSG00000141867 E058 27.4376664 0.0007101765 2.242929e-13 6.071966e-12 19 15332290 15332579 290 - 1.669 1.210 -1.586