ENSG00000141759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000588162 ENSG00000141759 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNL4A protein_coding protein_coding 210.8377 333.0405 158.3259 19.44598 3.957968 -1.072753 61.69518 104.36733 30.10939 1.811809 0.902683 -1.793044 0.2770875 0.3150667 0.1905667 -0.124500000 6.300479e-06 6.219028e-20 FALSE FALSE
ENST00000592957 ENSG00000141759 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNL4A protein_coding protein_coding 210.8377 333.0405 158.3259 19.44598 3.957968 -1.072753 60.67595 101.87856 48.82037 14.388114 2.387687 -1.061141 0.2902167 0.3028667 0.3081333 0.005266667 9.668000e-01 6.219028e-20   FALSE
MSTRG.15962.9 ENSG00000141759 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNL4A protein_coding   210.8377 333.0405 158.3259 19.44598 3.957968 -1.072753 62.31037 96.71769 50.80037 4.143842 2.451545 -0.928806 0.2961042 0.2911667 0.3208667 0.029700000 5.007621e-01 6.219028e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141759 E001 148.0989763 1.470777e-03 9.680871e-26 1.135611e-23 18 79970813 79971448 636 - 2.352 1.995 -1.193
ENSG00000141759 E002 53.1478100 4.946812e-04 1.295489e-13 3.626815e-12 18 79971449 79971583 135 - 1.913 1.557 -1.206
ENSG00000141759 E003 27.2391401 1.268821e-03 7.107702e-08 7.425050e-07 18 79971584 79971617 34 - 1.634 1.277 -1.230
ENSG00000141759 E004 57.9388334 4.098491e-04 3.320956e-23 3.016036e-21 18 79971618 79971714 97 - 2.003 1.551 -1.527
ENSG00000141759 E005 75.6944230 7.653345e-03 1.280286e-12 3.085047e-11 18 79971715 79971858 144 - 2.094 1.679 -1.398
ENSG00000141759 E006 27.7434677 7.345631e-04 1.188454e-09 1.736190e-08 18 79971859 79971861 3 - 1.658 1.262 -1.363
ENSG00000141759 E007 28.0724211 7.130914e-04 1.009768e-09 1.496617e-08 18 79971862 79971863 2 - 1.663 1.268 -1.361
ENSG00000141759 E008 161.1139890 2.370469e-03 9.016687e-36 2.308357e-33 18 79971864 79972874 1011 - 2.437 1.988 -1.501
ENSG00000141759 E009 97.0646743 3.448066e-04 9.834517e-27 1.237131e-24 18 79972875 79973406 532 - 2.188 1.805 -1.288
ENSG00000141759 E010 286.6437177 2.059607e-04 6.294931e-01 7.448539e-01 18 79973407 79973512 106 - 2.419 2.414 -0.020
ENSG00000141759 E011 350.3137295 9.564719e-04 8.650793e-05 4.587065e-04 18 79973513 79973521 9 - 2.421 2.527 0.354
ENSG00000141759 E012 351.1408467 6.961995e-04 3.202344e-03 1.086257e-02 18 79973522 79973524 3 - 2.445 2.522 0.255
ENSG00000141759 E013 479.7181768 9.631130e-04 8.396732e-04 3.400604e-03 18 79973525 79973533 9 - 2.575 2.657 0.274
ENSG00000141759 E014 538.0170785 9.534518e-04 1.645663e-03 6.107189e-03 18 79973534 79973541 8 - 2.630 2.705 0.250
ENSG00000141759 E015 700.6102309 1.149633e-03 6.879157e-05 3.742672e-04 18 79973542 79973565 24 - 2.731 2.822 0.303
ENSG00000141759 E016 1263.8625767 1.189947e-04 7.418126e-07 6.338076e-06 18 79973566 79973641 76 - 3.010 3.072 0.206
ENSG00000141759 E017 2952.5337944 5.344640e-05 1.293423e-17 6.263679e-16 18 79973642 79973856 215 - 3.377 3.440 0.211
ENSG00000141759 E018 22.2007376 8.629741e-04 3.995572e-01 5.433026e-01 18 79976718 79976787 70 - 1.366 1.307 -0.208
ENSG00000141759 E019 7.3426222 2.260892e-03 1.340302e-02 3.685232e-02 18 79977331 79977597 267 - 1.066 0.781 -1.080
ENSG00000141759 E020 1084.3748660 5.389445e-04 1.063585e-02 3.029789e-02 18 79977598 79977601 4 - 3.014 2.977 -0.123
ENSG00000141759 E021 1700.3528909 8.248396e-05 8.849534e-06 5.955723e-05 18 79977602 79977701 100 - 3.211 3.174 -0.124
ENSG00000141759 E022 9.2823619 8.193310e-03 3.208017e-01 4.639626e-01 18 79977702 79977917 216 - 1.048 0.937 -0.410
ENSG00000141759 E023 8.5148292 1.854748e-02 2.625084e-06 1.991089e-05 18 79979333 79979640 308 - 1.265 0.693 -2.147
ENSG00000141759 E024 5.1217564 2.097814e-02 1.533179e-01 2.661878e-01 18 79985797 79985866 70 - 0.890 0.692 -0.789
ENSG00000141759 E025 153.0623848 2.324181e-04 4.677039e-06 3.351556e-05 18 79986602 79986750 149 - 2.235 2.101 -0.448
ENSG00000141759 E026 1659.6230934 2.842407e-03 2.071157e-01 3.350702e-01 18 79988240 79988581 342 - 3.149 3.177 0.094
ENSG00000141759 E027 0.7332358 6.099421e-01 6.227936e-01 7.395179e-01 18 79994943 79995433 491 - 0.293 0.167 -1.041
ENSG00000141759 E028 0.9158852 1.408016e-02 3.348267e-01 4.785561e-01 18 80030521 80030577 57 - 0.389 0.219 -1.145
ENSG00000141759 E029 12.2496058 2.621617e-02 1.085746e-01 2.034353e-01 18 80033851 80033949 99 - 0.917 1.137 0.809