ENSG00000141756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321562 ENSG00000141756 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP10 protein_coding protein_coding 162.6122 206.5677 152.5851 10.15575 2.865685 -0.4369754 64.766657 75.01875 76.790704 11.2049424 2.7261492 0.033676092 0.39285833 0.36166667 0.50346667 0.141800000 1.277201e-01 9.807668e-31 FALSE TRUE
ENST00000464180 ENSG00000141756 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP10 protein_coding retained_intron 162.6122 206.5677 152.5851 10.15575 2.865685 -0.4369754 11.715643 12.20717 9.888141 1.6548222 0.1205666 -0.303680899 0.07512917 0.05873333 0.06486667 0.006133333 7.506094e-01 9.807668e-31 FALSE TRUE
ENST00000490938 ENSG00000141756 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP10 protein_coding retained_intron 162.6122 206.5677 152.5851 10.15575 2.865685 -0.4369754 21.476451 28.65856 14.251923 3.5273004 0.4876522 -1.007300978 0.13315833 0.13880000 0.09333333 -0.045466667 9.984418e-02 9.807668e-31 FALSE TRUE
MSTRG.14315.12 ENSG00000141756 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP10 protein_coding   162.6122 206.5677 152.5851 10.15575 2.865685 -0.4369754 8.853061 13.43022 5.039525 1.2164057 1.0252225 -1.412337271 0.05281667 0.06523333 0.03313333 -0.032100000 6.301280e-02 9.807668e-31 FALSE TRUE
MSTRG.14315.20 ENSG00000141756 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP10 protein_coding   162.6122 206.5677 152.5851 10.15575 2.865685 -0.4369754 9.181463 33.30688 0.000000 6.7603462 0.0000000 -11.702037652 0.04676250 0.16316667 0.00000000 -0.163166667 9.807668e-31 9.807668e-31 FALSE TRUE
MSTRG.14315.9 ENSG00000141756 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP10 protein_coding   162.6122 206.5677 152.5851 10.15575 2.865685 -0.4369754 20.712861 21.06371 21.181957 0.8283606 0.7569185 0.008072449 0.13091667 0.10220000 0.13893333 0.036733333 5.288493e-03 9.807668e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141756 E001 1.689817 9.091516e-03 1.637608e-01 2.800328e-01 17 41801947 41804349 2403 + 0.243 0.512 1.584
ENSG00000141756 E002 7.332099 2.273524e-03 5.540947e-01 6.831262e-01 17 41807803 41812500 4698 + 0.930 0.890 -0.152
ENSG00000141756 E003 4.799460 9.115819e-03 5.806335e-01 7.053316e-01 17 41812501 41812609 109 + 0.770 0.719 -0.205
ENSG00000141756 E004 3.566840 6.753508e-02 6.547657e-01 7.648596e-01 17 41812610 41812679 70 + 0.560 0.676 0.507
ENSG00000141756 E005 7.777095 4.229670e-03 1.784709e-01 2.992361e-01 17 41812680 41812694 15 + 1.001 0.874 -0.476
ENSG00000141756 E006 16.687354 1.298071e-03 5.933657e-02 1.255053e-01 17 41812695 41812714 20 + 1.305 1.179 -0.443
ENSG00000141756 E007 97.529874 4.280443e-04 1.844687e-01 3.068118e-01 17 41812715 41812739 25 + 1.989 1.973 -0.054
ENSG00000141756 E008 105.435119 5.130858e-04 4.227799e-01 5.659181e-01 17 41812790 41812901 112 + 2.009 2.013 0.014
ENSG00000141756 E009 64.527887 8.174285e-03 1.288047e-01 2.324898e-01 17 41812902 41812922 21 + 1.837 1.775 -0.210
ENSG00000141756 E010 42.162849 3.827599e-03 1.213102e-02 3.384799e-02 17 41812923 41812967 45 + 1.688 1.567 -0.411
ENSG00000141756 E011 88.494014 1.193026e-02 1.471757e-01 2.578411e-01 17 41812968 41812988 21 + 1.854 1.982 0.432
ENSG00000141756 E012 105.753606 9.098649e-03 2.387761e-01 3.727302e-01 17 41812989 41813003 15 + 1.946 2.050 0.349
ENSG00000141756 E013 234.290644 9.320593e-03 2.905687e-01 4.313854e-01 17 41813004 41813029 26 + 2.294 2.392 0.325
ENSG00000141756 E014 443.548190 9.231980e-03 9.628636e-01 9.805232e-01 17 41813030 41813154 125 + 2.608 2.649 0.136
ENSG00000141756 E015 354.479394 5.561359e-03 5.203595e-01 6.543376e-01 17 41813155 41813192 38 + 2.528 2.541 0.046
ENSG00000141756 E016 709.213746 3.388594e-03 6.697842e-03 2.043986e-02 17 41813193 41813279 87 + 2.865 2.819 -0.150
ENSG00000141756 E017 1.615708 9.998070e-03 6.396303e-01 7.529924e-01 17 41813487 41813490 4 + 0.328 0.430 0.587
ENSG00000141756 E018 2.541057 6.124959e-03 5.479715e-01 6.778999e-01 17 41813491 41813524 34 + 0.459 0.582 0.585
ENSG00000141756 E019 953.943585 2.279970e-03 1.457886e-06 1.169314e-05 17 41817058 41817203 146 + 3.016 2.932 -0.281
ENSG00000141756 E020 1233.889087 9.527437e-04 1.182166e-09 1.727269e-08 17 41818089 41818278 190 + 3.119 3.049 -0.233
ENSG00000141756 E021 1078.774095 3.055407e-04 7.152682e-12 1.525103e-10 17 41818382 41818527 146 + 3.052 2.995 -0.190
ENSG00000141756 E022 50.940954 3.693740e-03 2.613838e-05 1.577420e-04 17 41818528 41818602 75 + 1.812 1.606 -0.698
ENSG00000141756 E023 34.115578 9.901297e-04 1.961837e-06 1.528853e-05 17 41818603 41818641 39 + 1.667 1.412 -0.873
ENSG00000141756 E024 50.304648 3.687760e-03 4.207596e-08 4.608675e-07 17 41818870 41819209 340 + 1.841 1.561 -0.950
ENSG00000141756 E025 556.528819 1.235313e-04 5.538485e-02 1.186491e-01 17 41819210 41819254 45 + 2.728 2.732 0.011
ENSG00000141756 E026 1024.738745 8.964799e-05 3.482374e-05 2.036880e-04 17 41819255 41819399 145 + 3.005 2.990 -0.050
ENSG00000141756 E027 1257.317625 6.673187e-05 5.581215e-05 3.107095e-04 17 41819530 41819675 146 + 3.089 3.081 -0.028
ENSG00000141756 E028 79.703711 9.045538e-03 2.116315e-03 7.585113e-03 17 41819676 41819840 165 + 1.976 1.825 -0.509
ENSG00000141756 E029 87.976322 2.073439e-02 1.711562e-02 4.519735e-02 17 41819841 41820002 162 + 2.014 1.873 -0.476
ENSG00000141756 E030 47.022482 2.096629e-02 2.013750e-01 3.278975e-01 17 41820003 41820023 21 + 1.708 1.635 -0.248
ENSG00000141756 E031 35.573367 1.087598e-02 1.630133e-01 2.790695e-01 17 41820024 41820049 26 + 1.587 1.514 -0.248
ENSG00000141756 E032 107.089330 6.064610e-03 7.657081e-05 4.118012e-04 17 41820050 41820268 219 + 2.110 1.946 -0.550
ENSG00000141756 E033 1557.795434 7.746997e-05 1.180494e-03 4.575215e-03 17 41820269 41820442 174 + 3.175 3.178 0.009
ENSG00000141756 E034 694.516833 1.443800e-04 9.669430e-01 9.832767e-01 17 41820443 41820461 19 + 2.805 2.838 0.111
ENSG00000141756 E035 75.839690 9.829984e-03 2.177368e-05 1.338143e-04 17 41820462 41820599 138 + 1.993 1.765 -0.767
ENSG00000141756 E036 78.673891 3.482670e-04 3.035232e-10 4.934772e-09 17 41820600 41820706 107 + 2.006 1.786 -0.741
ENSG00000141756 E037 140.153253 1.065817e-03 1.081514e-07 1.091638e-06 17 41820707 41820946 240 + 2.216 2.072 -0.483
ENSG00000141756 E038 1411.282593 8.323006e-05 6.219030e-04 2.613234e-03 17 41820947 41821089 143 + 3.091 3.160 0.230
ENSG00000141756 E039 1622.248802 4.021566e-04 1.018804e-04 5.305955e-04 17 41821654 41821817 164 + 3.142 3.227 0.283
ENSG00000141756 E040 5559.171999 3.696937e-03 2.443673e-07 2.302988e-06 17 41822223 41823213 991 + 3.630 3.786 0.518