ENSG00000141736

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269571 ENSG00000141736 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBB2 protein_coding protein_coding 17.71009 21.57943 12.37952 1.45422 0.631988 -0.8012051 4.615576 4.7067958 3.7023074 0.3725732 0.5504535 -0.3454910 0.26586250 0.21780000 0.29890000 0.081100000 0.28184616 6.581982e-07 FALSE TRUE
ENST00000445658 ENSG00000141736 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBB2 protein_coding protein_coding 17.71009 21.57943 12.37952 1.45422 0.631988 -0.8012051 1.089354 1.6470155 0.6313291 0.2908024 0.2977826 -1.3694503 0.05788333 0.07540000 0.05123333 -0.024166667 0.66028739 6.581982e-07 FALSE TRUE
ENST00000541774 ENSG00000141736 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBB2 protein_coding protein_coding 17.71009 21.57943 12.37952 1.45422 0.631988 -0.8012051 7.762169 11.9709099 4.7200437 0.6481523 0.1789254 -1.3408121 0.42831250 0.55760000 0.38496667 -0.172633333 0.03344073 6.581982e-07 FALSE TRUE
ENST00000580074 ENSG00000141736 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBB2 protein_coding protein_coding 17.71009 21.57943 12.37952 1.45422 0.631988 -0.8012051 1.246427 0.7588769 0.4812108 0.2112594 0.4812108 -0.6464103 0.07277917 0.03423333 0.03696667 0.002733333 0.42954843 6.581982e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141736 E001 0.1817044 0.0397801663 1.000000e+00   17 39687914 39688100 187 + 0.000 0.089 9.475
ENSG00000141736 E002 0.1451727 0.0427671553 2.328872e-01   17 39688101 39688118 18 + 0.166 0.000 -14.172
ENSG00000141736 E003 3.0752009 0.0072436261 6.706237e-03 2.046091e-02 17 39688119 39688204 86 + 0.818 0.415 -1.803
ENSG00000141736 E004 7.3219851 0.0023808939 3.919157e-03 1.291571e-02 17 39688205 39688278 74 + 1.084 0.763 -1.218
ENSG00000141736 E005 10.3122775 0.0017895053 1.113595e-03 4.349212e-03 17 39688696 39688800 105 + 1.213 0.895 -1.163
ENSG00000141736 E006 9.0817322 0.0019191441 4.277457e-02 9.613621e-02 17 39693261 39693325 65 + 1.101 0.894 -0.762
ENSG00000141736 E007 4.9131987 0.0050757215 1.957045e-02 5.056413e-02 17 39694681 39694930 250 + 0.926 0.623 -1.218
ENSG00000141736 E008 1.7164108 0.5434079160 1.664847e-01 2.836410e-01 17 39694931 39694987 57 + 0.631 0.241 -2.145
ENSG00000141736 E009 13.8919006 0.0118218039 5.292438e-02 1.143427e-01 17 39694988 39695181 194 + 1.249 1.063 -0.665
ENSG00000141736 E010 0.4502799 0.0281477694 1.848032e-02 4.818720e-02 17 39699537 39699559 23 + 0.379 0.000 -15.893
ENSG00000141736 E011 0.9620705 0.0136968632 1.053513e-02 3.005571e-02 17 39699560 39699587 28 + 0.521 0.089 -3.346
ENSG00000141736 E012 4.4835429 0.0136428805 3.790950e-01 5.233853e-01 17 39699976 39700023 48 + 0.786 0.667 -0.484
ENSG00000141736 E013 5.1822347 0.0300188249 5.187870e-01 6.529791e-01 17 39700024 39700036 13 + 0.817 0.727 -0.360
ENSG00000141736 E014 7.0538435 0.0381149886 8.740894e-01 9.230413e-01 17 39700037 39700063 27 + 0.875 0.858 -0.064
ENSG00000141736 E015 7.2053589 0.0127012294 6.632489e-01 7.713495e-01 17 39700064 39700073 10 + 0.901 0.856 -0.172
ENSG00000141736 E016 7.6599052 0.0024933482 2.774503e-01 4.170108e-01 17 39700074 39700079 6 + 0.971 0.855 -0.439
ENSG00000141736 E017 23.3299617 0.0009194106 5.332739e-02 1.150730e-01 17 39700080 39700226 147 + 1.424 1.295 -0.448
ENSG00000141736 E018 29.9701879 0.0007523102 2.877743e-02 6.955687e-02 17 39700227 39700311 85 + 1.531 1.401 -0.446
ENSG00000141736 E019 0.0000000       17 39703194 39703428 235 +      
ENSG00000141736 E020 0.1482932 0.0414053921 1.000000e+00   17 39706749 39706897 149 + 0.000 0.089 11.936
ENSG00000141736 E021 74.0413359 0.0003451491 2.643631e-06 2.003232e-05 17 39706990 39707141 152 + 1.950 1.767 -0.617
ENSG00000141736 E022 2.9326798 0.0207905076 7.994087e-01 8.720407e-01 17 39707142 39707204 63 + 0.578 0.546 -0.145
ENSG00000141736 E023 1.7995036 0.0076520036 3.647548e-01 5.090890e-01 17 39707404 39708320 917 + 0.521 0.374 -0.762
ENSG00000141736 E024 108.8254593 0.0004443573 1.849783e-07 1.784115e-06 17 39708321 39708534 214 + 2.108 1.938 -0.571
ENSG00000141736 E025 0.1482932 0.0414053921 1.000000e+00   17 39709244 39709317 74 + 0.000 0.089 11.936
ENSG00000141736 E026 87.5394315 0.0011879373 4.148415e-05 2.382025e-04 17 39709318 39709452 135 + 2.004 1.848 -0.522
ENSG00000141736 E027 66.6255155 0.0003680489 1.440226e-02 3.913785e-02 17 39709813 39709881 69 + 1.849 1.753 -0.323
ENSG00000141736 E028 70.9117729 0.0003817492 1.791694e-02 4.695672e-02 17 39710086 39710201 116 + 1.871 1.782 -0.300
ENSG00000141736 E029 48.2409830 0.0008010214 1.650203e-01 2.817262e-01 17 39710340 39710355 16 + 1.684 1.624 -0.204
ENSG00000141736 E030 92.6036553 0.0003510997 1.499098e-01 2.615676e-01 17 39710356 39710481 126 + 1.953 1.912 -0.138
ENSG00000141736 E031 97.3639424 0.0017469588 1.499151e-01 2.615696e-01 17 39711928 39712047 120 + 1.979 1.934 -0.152
ENSG00000141736 E032 0.5848540 0.0431958971 2.755297e-01 4.148541e-01 17 39712048 39712321 274 + 0.000 0.227 13.490
ENSG00000141736 E033 105.4766309 0.0013331529 3.369650e-01 4.808307e-01 17 39712322 39712448 127 + 1.995 1.973 -0.076
ENSG00000141736 E034 0.4396707 0.0251113552 1.836652e-02 4.793533e-02 17 39713153 39713269 117 + 0.379 0.000 -15.931
ENSG00000141736 E035 84.6370796 0.0035351394 1.136013e-01 2.107856e-01 17 39715286 39715359 74 + 1.927 1.866 -0.206
ENSG00000141736 E036 99.6349900 0.0029645806 1.908347e-02 4.951932e-02 17 39715446 39715536 91 + 2.015 1.927 -0.298
ENSG00000141736 E037 144.6402481 0.0018323090 1.383001e-02 3.784016e-02 17 39715740 39715939 200 + 2.165 2.092 -0.244
ENSG00000141736 E038 10.2246522 0.0298366212 6.653230e-03 2.032434e-02 17 39715940 39716300 361 + 1.213 0.884 -1.204
ENSG00000141736 E039 112.4589491 0.0014970758 1.432523e-01 2.524532e-01 17 39716301 39716433 133 + 2.034 1.993 -0.139
ENSG00000141736 E040 0.2998086 0.0297113390 5.848456e-01   17 39716434 39716514 81 + 0.166 0.089 -1.028
ENSG00000141736 E041 67.0487815 0.0010797401 8.520659e-01 9.083009e-01 17 39716515 39716550 36 + 1.764 1.790 0.085
ENSG00000141736 E042 80.0410095 0.0045430763 8.357448e-01 8.972840e-01 17 39716551 39716605 55 + 1.838 1.868 0.102
ENSG00000141736 E043 0.6621601 0.0175832176 4.647967e-01 6.044950e-01 17 39716974 39717319 346 + 0.285 0.163 -1.025
ENSG00000141736 E044 68.1054093 0.0114642443 5.591114e-01 6.872607e-01 17 39717320 39717342 23 + 1.801 1.787 -0.047
ENSG00000141736 E045 100.9876526 0.0019272532 4.584826e-01 5.988008e-01 17 39717343 39717428 86 + 1.970 1.956 -0.048
ENSG00000141736 E046 81.2921385 0.0010556030 1.066402e-01 2.005939e-01 17 39717429 39717480 52 + 1.910 1.856 -0.183
ENSG00000141736 E047 1.4726239 0.0095660588 2.504900e-02 6.197532e-02 17 39717481 39717657 177 + 0.000 0.451 15.088
ENSG00000141736 E048 80.9084001 0.0020974123 9.741043e-03 2.812570e-02 17 39719787 39719834 48 + 1.941 1.839 -0.345
ENSG00000141736 E049 2.6215982 0.0057767404 1.454643e-01 2.554864e-01 17 39719835 39720297 463 + 0.673 0.451 -1.025
ENSG00000141736 E050 139.8512632 0.0006872981 7.397229e-02 1.498646e-01 17 39723319 39723457 139 + 2.134 2.090 -0.147
ENSG00000141736 E051 120.7073439 0.0002800433 2.902289e-01 4.310092e-01 17 39723538 39723624 87 + 2.054 2.034 -0.070
ENSG00000141736 E052 74.8800401 0.0003558986 7.975929e-01 8.708665e-01 17 39723625 39723660 36 + 1.832 1.836 0.015
ENSG00000141736 E053 125.0149583 0.0002524788 4.800598e-01 6.183695e-01 17 39723912 39724010 99 + 2.062 2.053 -0.028
ENSG00000141736 E054 182.8854927 0.0003148816 7.947732e-01 8.689003e-01 17 39724726 39724911 186 + 2.204 2.227 0.079
ENSG00000141736 E055 166.4169406 0.0002376563 5.649441e-01 6.921533e-01 17 39725049 39725204 156 + 2.153 2.186 0.111
ENSG00000141736 E056 2.2874308 0.0539902086 2.610068e-01 3.986114e-01 17 39725205 39725326 122 + 0.285 0.521 1.319
ENSG00000141736 E057 104.9044463 0.0003150661 4.143698e-03 1.354519e-02 17 39725327 39725402 76 + 1.882 2.010 0.430
ENSG00000141736 E058 2.5829756 0.0069010413 2.510836e-01 3.872370e-01 17 39725403 39725706 304 + 0.628 0.451 -0.831
ENSG00000141736 E059 157.7160491 0.0002538912 7.944183e-03 2.363902e-02 17 39725707 39725853 147 + 2.080 2.180 0.334
ENSG00000141736 E060 3.5010534 0.0044127744 2.899432e-03 9.967676e-03 17 39725854 39726351 498 + 0.875 0.451 -1.833
ENSG00000141736 E061 149.6193768 0.0002921392 9.294231e-03 2.701967e-02 17 39726562 39726659 98 + 2.054 2.155 0.338
ENSG00000141736 E062 190.2477559 0.0002301280 7.756856e-03 2.316638e-02 17 39726815 39727003 189 + 2.165 2.258 0.310
ENSG00000141736 E063 199.0857244 0.0004127630 3.721178e-04 1.666429e-03 17 39727295 39727547 253 + 2.169 2.289 0.399
ENSG00000141736 E064 515.2965788 0.0053833359 7.387118e-05 3.986973e-04 17 39727689 39728347 659 + 2.545 2.712 0.556
ENSG00000141736 E065 124.6518404 0.0050969819 1.354426e-03 5.157833e-03 17 39728348 39728385 38 + 1.922 2.102 0.603
ENSG00000141736 E066 156.6474725 0.0071749398 1.954117e-04 9.442230e-04 17 39728386 39728481 96 + 1.991 2.208 0.726
ENSG00000141736 E067 84.9831289 0.0062532104 7.181202e-03 2.169477e-02 17 39728482 39728662 181 + 1.764 1.938 0.586
ENSG00000141736 E068 2.4837993 0.0250594069 5.396774e-01 6.709208e-01 17 39730023 39730538 516 + 0.578 0.484 -0.443