ENSG00000141699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309428 ENSG00000141699 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG3 protein_coding protein_coding 27.83528 36.08686 17.53306 1.412054 0.2273879 -1.040973 24.78308 33.95472 14.77641 1.004305 0.3349156 -1.199765 0.8815875 0.9416333 0.8430333 -0.0986 0.003372759 0.003372759 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141699 E001 1.8486971 0.0102799545 9.054425e-03 2.641332e-02 17 42579513 42579514 2 - 0.675 0.281 -2.037
ENSG00000141699 E002 278.9764612 0.0085567497 2.352347e-08 2.704649e-07 17 42579515 42579731 217 - 2.122 2.482 1.201
ENSG00000141699 E003 536.6715053 0.0076059181 9.983967e-13 2.451630e-11 17 42579732 42579897 166 - 2.384 2.768 1.277
ENSG00000141699 E004 1200.2759868 0.0027309831 1.262732e-18 6.872690e-17 17 42579898 42580844 947 - 2.828 3.098 0.900
ENSG00000141699 E005 174.1173795 0.0005605286 4.039749e-04 1.789841e-03 17 42580845 42581011 167 - 2.061 2.243 0.607
ENSG00000141699 E006 175.2897049 0.0007018004 5.422367e-01 6.730259e-01 17 42581012 42581169 158 - 2.140 2.226 0.288
ENSG00000141699 E007 162.0494052 0.0012335883 1.156049e-04 5.936999e-04 17 42581170 42581328 159 - 2.211 2.149 -0.207
ENSG00000141699 E008 71.4735775 0.0003849623 1.461135e-01 2.564052e-01 17 42581329 42581340 12 - 1.818 1.818 0.001
ENSG00000141699 E009 232.7608680 0.0001860118 1.907586e-07 1.835195e-06 17 42581341 42581612 272 - 2.367 2.305 -0.208
ENSG00000141699 E010 441.2584792 0.0010846782 1.626812e-09 2.319345e-08 17 42581613 42582270 658 - 2.648 2.580 -0.226
ENSG00000141699 E011 123.9037188 0.0022526525 5.382961e-09 6.982443e-08 17 42582674 42582734 61 - 2.160 1.996 -0.547
ENSG00000141699 E012 121.2936314 0.0041493464 1.222949e-08 1.484108e-07 17 42582735 42582806 72 - 2.167 1.979 -0.629
ENSG00000141699 E013 129.5903492 0.0018449914 9.557152e-10 1.422289e-08 17 42583498 42583580 83 - 2.180 2.017 -0.547
ENSG00000141699 E014 113.1430492 0.0075302628 5.204391e-04 2.236286e-03 17 42585125 42585200 76 - 2.094 1.975 -0.397
ENSG00000141699 E015 57.1229198 0.0004479826 6.425033e-03 1.972745e-02 17 42585201 42585210 10 - 1.769 1.700 -0.234
ENSG00000141699 E016 91.7066642 0.0003843186 1.351946e-04 6.821192e-04 17 42585211 42585262 52 - 1.982 1.899 -0.281
ENSG00000141699 E017 109.1396744 0.0003113077 1.665638e-08 1.970587e-07 17 42586053 42586137 85 - 2.090 1.956 -0.450
ENSG00000141699 E018 10.9837053 0.1001943023 3.889626e-03 1.283514e-02 17 42586138 42586432 295 - 1.294 0.877 -1.516
ENSG00000141699 E019 58.3866738 0.0004820935 6.139392e-05 3.383533e-04 17 42586765 42586767 3 - 1.818 1.690 -0.433
ENSG00000141699 E020 121.7670739 0.0035180046 4.255202e-06 3.074857e-05 17 42586768 42586891 124 - 2.135 2.003 -0.444
ENSG00000141699 E021 5.5085641 0.0066241366 1.001659e-03 3.964095e-03 17 42586892 42586957 66 - 1.014 0.644 -1.453
ENSG00000141699 E022 2.9767652 0.0766637921 8.337656e-03 2.463678e-02 17 42587695 42587833 139 - 0.818 0.378 -2.009
ENSG00000141699 E023 78.2598100 0.0110323633 3.274539e-05 1.930255e-04 17 42587834 42587864 31 - 1.986 1.788 -0.669
ENSG00000141699 E024 91.0941085 0.0151846913 1.462817e-04 7.310955e-04 17 42592056 42592131 76 - 2.048 1.853 -0.655
ENSG00000141699 E025 68.0157471 0.0249816680 6.481173e-03 1.987437e-02 17 42592132 42592162 31 - 1.902 1.740 -0.545
ENSG00000141699 E026 2.1410276 0.0147040450 9.170918e-01 9.516151e-01 17 42596533 42596627 95 - 0.457 0.483 0.132
ENSG00000141699 E027 0.3299976 0.0276244424 5.600657e-01   17 42605248 42605291 44 - 0.000 0.163 9.944
ENSG00000141699 E028 0.6589510 0.0190798284 8.542293e-01 9.098284e-01 17 42608660 42609085 426 - 0.166 0.226 0.549
ENSG00000141699 E029 130.5953849 0.0108481936 8.133118e-04 3.306619e-03 17 42609086 42609386 301 - 2.160 2.033 -0.424
ENSG00000141699 E030 0.7395785 0.1337686547 4.305666e-01 5.731943e-01 17 42609498 42609727 230 - 0.286 0.165 -1.009
ENSG00000141699 E031 0.2214452 0.0392498736 1.000000e+00   17 42610537 42610623 87 - 0.000 0.089 8.803