ENSG00000141698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393910 ENSG00000141698 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C3B protein_coding retained_intron 211.5216 359.0934 147.3729 31.59557 3.941302 -1.28483 34.64643 65.27427 19.27314 2.682540 0.5934800 -1.7593958 0.15696250 0.18343333 0.13113333 -0.05230000 0.01416718 7.577717e-11 FALSE  
ENST00000435506 ENSG00000141698 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C3B protein_coding protein_coding 211.5216 359.0934 147.3729 31.59557 3.941302 -1.28483 16.53976 27.05282 13.75864 6.253817 0.5803431 -0.9749256 0.08464167 0.07366667 0.09363333 0.01996667 0.49735425 7.577717e-11 FALSE  
ENST00000523903 ENSG00000141698 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C3B protein_coding retained_intron 211.5216 359.0934 147.3729 31.59557 3.941302 -1.28483 92.28065 132.98670 69.98483 19.294064 5.3237922 -0.9260701 0.43485417 0.37640000 0.47363333 0.09723333 0.48981746 7.577717e-11 FALSE  
MSTRG.14317.7 ENSG00000141698 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C3B protein_coding   211.5216 359.0934 147.3729 31.59557 3.941302 -1.28483 40.66205 87.80999 19.98643 17.472914 2.5293020 -2.1348066 0.18316250 0.24113333 0.13673333 -0.10440000 0.07337065 7.577717e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141698 E001 2.647533 5.777469e-03 6.655732e-01 7.732267e-01 17 41825057 41825180 124 - 0.566 0.501 -0.304
ENSG00000141698 E002 6.192008 4.224010e-02 1.200423e-01 2.200492e-01 17 41825181 41825199 19 - 0.566 0.867 1.246
ENSG00000141698 E003 62.729513 1.156326e-02 3.396012e-01 4.835327e-01 17 41825200 41825226 27 - 1.781 1.726 -0.186
ENSG00000141698 E004 125.830673 5.074922e-04 5.710514e-10 8.861728e-09 17 41825227 41825237 11 - 2.185 1.982 -0.680
ENSG00000141698 E005 3413.651887 1.593428e-03 2.661147e-07 2.489365e-06 17 41825238 41825653 416 - 3.380 3.484 0.343
ENSG00000141698 E006 1261.885428 1.362747e-03 2.615718e-05 1.578454e-04 17 41825654 41825657 4 - 2.955 3.052 0.322
ENSG00000141698 E007 3398.643020 4.507399e-04 1.524567e-03 5.716803e-03 17 41827426 41827626 201 - 3.427 3.471 0.146
ENSG00000141698 E008 33.583493 6.159799e-04 1.276665e-04 6.485235e-04 17 41828322 41828789 468 - 1.637 1.406 -0.791
ENSG00000141698 E009 1305.518327 3.216918e-04 4.188462e-01 5.620942e-01 17 41828790 41828804 15 - 3.049 3.048 -0.003
ENSG00000141698 E010 1352.114387 6.681488e-04 1.368581e-01 2.437105e-01 17 41828805 41828829 25 - 3.074 3.059 -0.050
ENSG00000141698 E011 1956.533884 3.900917e-04 8.912070e-01 9.345141e-01 17 41828830 41828904 75 - 3.217 3.225 0.026
ENSG00000141698 E012 1530.666098 9.265591e-04 2.070446e-01 3.350000e-01 17 41828905 41828952 48 - 3.091 3.123 0.106
ENSG00000141698 E013 2145.254227 1.724986e-04 7.416085e-01 8.307101e-01 17 41830801 41830890 90 - 3.253 3.267 0.045
ENSG00000141698 E014 1806.648185 5.315647e-05 1.825927e-01 3.044640e-01 17 41832392 41832477 86 - 3.191 3.190 -0.004
ENSG00000141698 E015 12.562064 5.014813e-03 3.951621e-08 4.350688e-07 17 41832478 41832607 130 - 1.400 0.876 -1.889
ENSG00000141698 E016 5.616160 2.987232e-02 3.204619e-04 1.462623e-03 17 41832608 41832703 96 - 1.089 0.576 -2.027
ENSG00000141698 E017 1028.623940 9.087258e-05 4.685862e-01 6.079919e-01 17 41835070 41835081 12 - 2.944 2.946 0.007
ENSG00000141698 E018 1156.162987 2.386531e-04 4.956802e-06 3.530268e-05 17 41835082 41835116 35 - 3.034 2.982 -0.172
ENSG00000141698 E019 1150.751551 8.123573e-04 2.771841e-04 1.286768e-03 17 41835203 41835272 70 - 3.034 2.977 -0.192
ENSG00000141698 E020 12.282164 1.582140e-03 3.595747e-09 4.807703e-08 17 41835273 41835498 226 - 1.400 0.853 -1.978
ENSG00000141698 E021 37.479866 5.566583e-04 1.696101e-10 2.878706e-09 17 41835588 41835642 55 - 1.766 1.406 -1.229
ENSG00000141698 E022 21.555489 8.593691e-04 1.663838e-09 2.366968e-08 17 41835643 41835682 40 - 1.574 1.135 -1.528
ENSG00000141698 E023 10.827016 2.142444e-03 1.198407e-09 1.749246e-08 17 41835683 41835858 176 - 1.371 0.774 -2.188
ENSG00000141698 E024 1098.271761 4.167422e-03 1.667202e-02 4.421700e-02 17 41835859 41835957 99 - 3.025 2.950 -0.249
ENSG00000141698 E025 796.397467 1.342386e-02 2.646375e-01 4.025984e-01 17 41835958 41836078 121 - 2.874 2.814 -0.200
ENSG00000141698 E026 564.351267 1.769790e-02 2.256607e-01 3.571730e-01 17 41836079 41836181 103 - 2.736 2.661 -0.250
ENSG00000141698 E027 420.165698 1.087926e-02 3.850758e-02 8.829115e-02 17 41836182 41836260 79 - 2.633 2.524 -0.365