ENSG00000141664

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269499 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding protein_coding 5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 0.4908664 0.3053756 0.7219070 0.16277574 0.09192248 1.2145894 0.09239167 0.06910000 0.10986667 0.04076667 6.428574e-01 1.439697e-06 FALSE TRUE
ENST00000585873 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding nonsense_mediated_decay 5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 0.4052290 0.3142910 0.6426716 0.16662572 0.06394382 1.0090682 0.07316250 0.07656667 0.09813333 0.02156667 7.872164e-01 1.439697e-06 TRUE TRUE
ENST00000585949 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding retained_intron 5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 0.5539822 1.2770958 0.4629290 0.46966010 0.21182630 -1.4444240 0.12072917 0.32223333 0.06873333 -0.25350000 1.227224e-01 1.439697e-06 FALSE TRUE
ENST00000586834 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding protein_coding 5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 2.5585820 1.3049399 3.2586579 0.32902586 0.32772582 1.3137015 0.48226667 0.30283333 0.50263333 0.19980000 2.240233e-01 1.439697e-06 FALSE TRUE
ENST00000588676 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding protein_coding 5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 0.3786638 0.4715051 0.3215839 0.07323137 0.04308009 -0.5381771 0.07790417 0.11183333 0.04960000 -0.06223333 5.686515e-02 1.439697e-06 FALSE TRUE
ENST00000591145 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding nonsense_mediated_decay 5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 0.1140041 0.2896923 0.0000000 0.14489481 0.00000000 -4.9054100 0.02794583 0.06483333 0.00000000 -0.06483333 1.064832e-01 1.439697e-06 TRUE FALSE
MSTRG.15873.5 ENSG00000141664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC2 protein_coding   5.167257 4.198116 6.538911 0.2691232 0.2260667 0.6380806 0.2372365 0.0000000 0.5198224 0.00000000 0.09152025 5.7274370 0.04034583 0.00000000 0.07873333 0.07873333 1.439697e-06 1.439697e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141664 E001 2.4712417 0.0475420977 5.152780e-01 0.6499624895 18 62523025 62523197 173 + 0.459 0.620 0.755
ENSG00000141664 E002 3.5805612 0.0070495092 9.371468e-01 0.9644915150 18 62523198 62523618 421 + 0.632 0.664 0.138
ENSG00000141664 E003 1.2618922 0.1111536641 5.116383e-01 0.6466027768 18 62523619 62523666 48 + 0.382 0.280 -0.640
ENSG00000141664 E004 20.4802407 0.0272718599 2.301959e-01 0.3626876801 18 62523667 62524157 491 + 1.345 1.281 -0.221
ENSG00000141664 E005 5.8500423 0.0138340005 3.080242e-01 0.4502568900 18 62524158 62524172 15 + 0.865 0.775 -0.353
ENSG00000141664 E006 19.5250985 0.0014100830 8.873727e-01 0.9320242740 18 62524173 62524363 191 + 1.285 1.329 0.151
ENSG00000141664 E007 13.5945008 0.0180430528 5.983221e-06 0.0000418715 18 62524364 62525495 1132 + 0.851 1.399 1.981
ENSG00000141664 E008 0.1472490 0.0434144466 7.982919e-01   18 62526889 62526981 93 + 0.092 0.000 -10.132
ENSG00000141664 E009 0.1451727 0.0432899068 7.985593e-01   18 62539514 62539680 167 + 0.091 0.000 -10.132
ENSG00000141664 E010 22.8120506 0.0247603097 1.560608e-02 0.0418593505 18 62539681 62539792 112 + 1.431 1.229 -0.707
ENSG00000141664 E011 22.7828963 0.0332088732 3.203446e-03 0.0108661128 18 62542498 62542574 77 + 1.453 1.166 -1.003
ENSG00000141664 E012 19.0606988 0.0013600901 2.607138e-04 0.0012195720 18 62544802 62544873 72 + 1.376 1.120 -0.901
ENSG00000141664 E013 28.4260145 0.0007906220 9.886171e-05 0.0005165211 18 62550348 62550460 113 + 1.526 1.310 -0.748
ENSG00000141664 E014 27.6258731 0.0007287262 3.848925e-02 0.0882630179 18 62556203 62556297 95 + 1.475 1.389 -0.297
ENSG00000141664 E015 1.1220049 0.1648199368 2.684414e-01 0.4068954871 18 62558542 62558686 145 + 0.382 0.163 -1.629
ENSG00000141664 E016 22.5429849 0.0011318945 6.002395e-02 0.1266439091 18 62558687 62558770 84 + 1.388 1.300 -0.307
ENSG00000141664 E017 0.7469680 0.0168651352 6.317949e-02 0.1320036260 18 62560353 62560586 234 + 0.337 0.000 -12.455
ENSG00000141664 E018 19.4962754 0.0084850961 1.063556e-01 0.2001604594 18 62560587 62560644 58 + 1.331 1.238 -0.327
ENSG00000141664 E019 27.4747484 0.0007524163 9.046894e-02 0.1758664941 18 62563009 62563144 136 + 1.465 1.404 -0.208
ENSG00000141664 E020 21.6931441 0.0008806470 1.451817e-02 0.0394060570 18 62564571 62564635 65 + 1.393 1.259 -0.466
ENSG00000141664 E021 28.2975241 0.0007440752 4.348058e-02 0.0974351463 18 62565002 62565096 95 + 1.485 1.404 -0.278
ENSG00000141664 E022 31.7997956 0.0132547416 1.296697e-01 0.2336882147 18 62570103 62570231 129 + 1.529 1.463 -0.226
ENSG00000141664 E023 68.1523963 0.0010254306 9.345355e-04 0.0037351257 18 62574057 62574478 422 + 1.862 1.769 -0.312
ENSG00000141664 E024 39.6397347 0.0005528663 1.662993e-02 0.0441220363 18 62574479 62574644 166 + 1.629 1.548 -0.275
ENSG00000141664 E025 50.0534938 0.0005851906 8.708307e-01 0.9209913725 18 62574645 62574926 282 + 1.676 1.724 0.161
ENSG00000141664 E026 54.5712306 0.0054852329 1.354095e-01 0.2416848573 18 62574927 62575297 371 + 1.672 1.812 0.473
ENSG00000141664 E027 14.9483184 0.0012217029 5.180355e-02 0.1123696480 18 62575298 62575312 15 + 1.088 1.310 0.786
ENSG00000141664 E028 52.9622929 0.0023000028 4.901967e-01 0.6275428585 18 62575313 62575550 238 + 1.685 1.775 0.307
ENSG00000141664 E029 40.5539687 0.0005506621 3.005981e-02 0.0720725447 18 62576512 62576652 141 + 1.631 1.564 -0.228
ENSG00000141664 E030 216.8443554 0.0251453832 3.425673e-04 0.0015505147 18 62576653 62578579 1927 + 2.197 2.477 0.935
ENSG00000141664 E031 0.1817044 0.0387771190 2.927259e-01   18 62581805 62581896 92 + 0.000 0.162 11.747
ENSG00000141664 E032 6.0368021 0.0076974186 9.651101e-01 0.9820401621 18 62584446 62584595 150 + 0.821 0.865 0.167
ENSG00000141664 E033 32.2426363 0.0007197138 2.566467e-05 0.0001551600 18 62584596 62586729 2134 + 1.363 1.673 1.062
ENSG00000141664 E034 2.4420969 0.0210371962 4.778945e-01 0.6163796648 18 62586849 62586907 59 + 0.459 0.619 0.751
ENSG00000141664 E035 2.1444533 0.0075518738 6.343460e-01 0.7488274900 18 62587581 62587709 129 + 0.493 0.448 -0.224