ENSG00000141627

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269445 ENSG00000141627 HEK293_OSMI2_2hA HEK293_TMG_2hB DYM protein_coding protein_coding 16.93273 15.17233 19.51779 1.696744 0.520469 0.3631351 4.256673 4.146273 5.066023 0.5462853 0.2498718 0.2884083 0.26035833 0.2736000 0.26046667 -0.01313333 8.965161e-01 5.662809e-15 FALSE TRUE
ENST00000442713 ENSG00000141627 HEK293_OSMI2_2hA HEK293_TMG_2hB DYM protein_coding protein_coding 16.93273 15.17233 19.51779 1.696744 0.520469 0.3631351 1.425318 1.651446 1.826478 0.9198522 0.9680594 0.1445021 0.08704583 0.1102667 0.09110000 -0.01916667 9.945864e-01 5.662809e-15 FALSE TRUE
ENST00000577734 ENSG00000141627 HEK293_OSMI2_2hA HEK293_TMG_2hB DYM protein_coding protein_coding 16.93273 15.17233 19.51779 1.696744 0.520469 0.3631351 2.272156 3.634047 1.131616 0.4255448 0.1294508 -1.6744638 0.14573750 0.2397000 0.05793333 -0.18176667 5.662809e-15 5.662809e-15 FALSE FALSE
MSTRG.15787.7 ENSG00000141627 HEK293_OSMI2_2hA HEK293_TMG_2hB DYM protein_coding   16.93273 15.17233 19.51779 1.696744 0.520469 0.3631351 5.191336 1.966071 5.522905 0.6500320 0.8257871 1.4854028 0.29505000 0.1311333 0.28546667 0.15433333 1.374753e-01 5.662809e-15 FALSE TRUE
MSTRG.15787.8 ENSG00000141627 HEK293_OSMI2_2hA HEK293_TMG_2hB DYM protein_coding   16.93273 15.17233 19.51779 1.696744 0.520469 0.3631351 2.323322 2.384014 3.448884 0.2443482 0.3739522 0.5308750 0.12600833 0.1593333 0.17590000 0.01656667 8.091888e-01 5.662809e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141627 E001 31.6072301 0.0095525356 4.242548e-12 9.383981e-11 18 49036387 49041473 5087 - 1.707 1.098 -2.112
ENSG00000141627 E002 254.1209577 0.0003796488 1.981583e-07 1.899822e-06 18 49041474 49043668 2195 - 2.353 2.470 0.389
ENSG00000141627 E003 41.9041161 0.0005482614 2.353741e-04 1.114188e-03 18 49043669 49043803 135 - 1.725 1.523 -0.690
ENSG00000141627 E004 47.1773980 0.0005036182 3.709234e-02 8.564643e-02 18 49043804 49043844 41 - 1.638 1.742 0.353
ENSG00000141627 E005 45.5721982 0.0008085434 6.640573e-02 1.374017e-01 18 49043845 49043846 2 - 1.629 1.724 0.321
ENSG00000141627 E006 53.1085160 0.0014225856 1.932440e-02 5.003620e-02 18 49043847 49043853 7 - 1.684 1.801 0.395
ENSG00000141627 E007 84.2804210 0.0035328409 2.428980e-02 6.041342e-02 18 49043854 49043902 49 - 1.884 1.989 0.353
ENSG00000141627 E008 196.0891403 0.0026448856 8.754704e-06 5.895817e-05 18 49043903 49044204 302 - 2.222 2.372 0.504
ENSG00000141627 E009 5.6357582 0.0030574864 1.864431e-04 9.055293e-04 18 49093217 49093311 95 - 0.516 1.012 2.027
ENSG00000141627 E010 0.1451727 0.0436283176 6.481584e-01   18 49097185 49097401 217 - 0.109 0.000 -10.773
ENSG00000141627 E011 117.8158321 0.0010356029 8.823203e-11 1.571873e-09 18 49097402 49097498 97 - 1.961 2.188 0.761
ENSG00000141627 E012 74.6058127 0.0005120945 6.817769e-07 5.867469e-06 18 49097499 49097515 17 - 1.780 1.982 0.681
ENSG00000141627 E013 0.0000000       18 49114508 49114615 108 -      
ENSG00000141627 E014 0.2214452 0.0572818212 3.691060e-01   18 49116025 49116189 165 - 0.000 0.138 11.271
ENSG00000141627 E015 196.3181663 0.0002945343 1.000263e-07 1.015524e-06 18 49118744 49118926 183 - 2.233 2.366 0.445
ENSG00000141627 E016 143.1651523 0.0002388376 1.715201e-02 4.527851e-02 18 49163685 49163787 103 - 2.131 2.199 0.227
ENSG00000141627 E017 0.0000000       18 49209551 49209715 165 -      
ENSG00000141627 E018 139.5408532 0.0002426829 8.650568e-02 1.698175e-01 18 49257010 49257104 95 - 2.129 2.178 0.164
ENSG00000141627 E019 142.2883655 0.0002538068 2.799752e-01 4.197800e-01 18 49258380 49258493 114 - 2.147 2.177 0.100
ENSG00000141627 E020 127.9511495 0.0006796150 2.099452e-01 3.384654e-01 18 49272178 49272303 126 - 2.097 2.135 0.127
ENSG00000141627 E021 159.8852623 0.0002745364 9.361054e-01 9.638219e-01 18 49281997 49282167 171 - 2.212 2.212 0.001
ENSG00000141627 E022 69.0813313 0.0006822793 3.572415e-01 5.016434e-01 18 49282168 49282175 8 - 1.872 1.831 -0.138
ENSG00000141627 E023 74.9171313 0.0004402359 8.788563e-02 1.719049e-01 18 49286434 49286447 14 - 1.921 1.850 -0.238
ENSG00000141627 E024 69.2526967 0.0004174241 1.256483e-01 2.280725e-01 18 49286448 49286451 4 - 1.885 1.819 -0.222
ENSG00000141627 E025 82.9747923 0.0003628394 1.816367e-01 3.032861e-01 18 49286452 49286487 36 - 1.956 1.904 -0.178
ENSG00000141627 E026 59.7797007 0.0004328986 1.948624e-01 3.198249e-01 18 49286488 49286488 1 - 1.819 1.759 -0.203
ENSG00000141627 E027 64.4944718 0.0003795419 1.613203e-01 2.768114e-01 18 49286489 49286496 8 - 1.852 1.789 -0.211
ENSG00000141627 E028 104.2649715 0.0003089468 2.311743e-02 5.799163e-02 18 49286497 49286613 117 - 2.066 1.986 -0.268
ENSG00000141627 E029 39.1205354 0.0005578182 8.442841e-01 9.030793e-01 18 49286614 49286616 3 - 1.615 1.602 -0.042
ENSG00000141627 E030 0.5985731 0.0212136299 4.573373e-01 5.976656e-01 18 49321125 49321377 253 - 0.268 0.137 -1.204
ENSG00000141627 E031 0.4396707 0.0285734077 1.413978e-01 2.499547e-01 18 49329573 49329707 135 - 0.268 0.000 -12.358
ENSG00000141627 E032 109.2581550 0.0022543066 9.892465e-01 9.973115e-01 18 49331864 49332006 143 - 2.049 2.041 -0.025
ENSG00000141627 E033 77.0478254 0.0004440804 1.079062e-01 2.024310e-01 18 49333728 49333853 126 - 1.927 1.859 -0.227
ENSG00000141627 E034 0.0000000       18 49359749 49359872 124 -      
ENSG00000141627 E035 57.2520020 0.0117249513 5.828441e-01 7.070919e-01 18 49363161 49363218 58 - 1.790 1.746 -0.147
ENSG00000141627 E036 41.3141461 0.0156241024 8.570252e-01 9.116633e-01 18 49363219 49363233 15 - 1.640 1.623 -0.058
ENSG00000141627 E037 0.0000000       18 49368602 49368617 16 -      
ENSG00000141627 E038 0.0000000       18 49368618 49368671 54 -      
ENSG00000141627 E039 0.0000000       18 49368672 49368713 42 -      
ENSG00000141627 E040 0.6621732 0.0805319374 7.926499e-01 8.674319e-01 18 49375648 49375724 77 - 0.196 0.242 0.386
ENSG00000141627 E041 63.4574955 0.0077897446 5.200039e-01 6.540394e-01 18 49378567 49378622 56 - 1.835 1.792 -0.146
ENSG00000141627 E042 57.4931456 0.0008859128 1.391563e-01 2.469022e-01 18 49378623 49378658 36 - 1.808 1.736 -0.243
ENSG00000141627 E043 64.0066513 0.0008937351 1.018187e-03 4.021525e-03 18 49378659 49378700 42 - 1.884 1.730 -0.518
ENSG00000141627 E044 85.0548219 0.0004957644 1.402594e-05 9.005840e-05 18 49379665 49379745 81 - 2.014 1.841 -0.582
ENSG00000141627 E045 51.9447761 0.0005183160 1.694454e-04 8.327305e-04 18 49379746 49379758 13 - 1.810 1.622 -0.637
ENSG00000141627 E046 2.2830943 0.0070141932 8.055857e-01 8.763972e-01 18 49390720 49390812 93 - 0.516 0.556 0.188
ENSG00000141627 E047 0.4407149 0.0217681645 7.435683e-01 8.321870e-01 18 49391385 49391451 67 - 0.196 0.137 -0.618
ENSG00000141627 E048 50.5595578 0.0007622857 1.005411e-04 5.243841e-04 18 49391593 49391609 17 - 1.802 1.602 -0.678
ENSG00000141627 E049 48.9807842 0.0022035284 3.457868e-05 2.024672e-04 18 49391610 49391619 10 - 1.798 1.564 -0.794
ENSG00000141627 E050 52.9243914 0.0066255004 3.003884e-04 1.381187e-03 18 49391620 49391642 23 - 1.832 1.597 -0.797
ENSG00000141627 E051 35.0576837 0.0009044965 5.487641e-04 2.342377e-03 18 49391643 49391645 3 - 1.649 1.437 -0.724
ENSG00000141627 E052 1.8811779 0.0076999613 1.947065e-01 3.196324e-01 18 49393645 49393742 98 - 0.552 0.325 -1.201
ENSG00000141627 E053 0.0000000       18 49411905 49411941 37 -      
ENSG00000141627 E054 0.0000000       18 49412967 49413132 166 -      
ENSG00000141627 E055 0.8084787 0.0604845350 3.110351e-01 4.534771e-01 18 49417935 49417938 4 - 0.330 0.138 -1.609
ENSG00000141627 E056 1.1814393 0.3792244341 6.268533e-01 7.427370e-01 18 49417939 49418053 115 - 0.384 0.250 -0.872
ENSG00000141627 E057 0.2214452 0.0572818212 3.691060e-01   18 49418054 49418057 4 - 0.000 0.138 11.271
ENSG00000141627 E058 109.9329020 0.0039359355 8.759001e-07 7.363508e-06 18 49430255 49430447 193 - 2.144 1.910 -0.784
ENSG00000141627 E059 85.7158739 0.0196978321 5.149932e-02 1.118134e-01 18 49460398 49460802 405 - 2.012 1.837 -0.588
ENSG00000141627 E060 0.0000000       18 49461176 49461347 172 -