ENSG00000141622

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269439 ENSG00000141622 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF165 protein_coding protein_coding 0.7191819 0.9114414 0.5338723 0.06835246 0.0130373 -0.7606244 0.23695388 0.23623187 0.31107997 0.04466048 0.04434974 0.3829151 0.3671625 0.25436667 0.58546667 0.33110000 0.0431068506 1.38355e-05 FALSE TRUE
ENST00000543885 ENSG00000141622 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF165 protein_coding protein_coding 0.7191819 0.9114414 0.5338723 0.06835246 0.0130373 -0.7606244 0.01909286 0.00000000 0.03998305 0.00000000 0.03998305 2.3214389 0.0424500 0.00000000 0.07143333 0.07143333 0.6758798763 1.38355e-05 FALSE TRUE
ENST00000586604 ENSG00000141622 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF165 protein_coding nonsense_mediated_decay 0.7191819 0.9114414 0.5338723 0.06835246 0.0130373 -0.7606244 0.15794523 0.39705360 0.00000000 0.05455089 0.00000000 -5.3471469 0.1745167 0.44323333 0.00000000 -0.44323333 0.0000138355 1.38355e-05 FALSE TRUE
ENST00000587853 ENSG00000141622 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF165 protein_coding protein_coding 0.7191819 0.9114414 0.5338723 0.06835246 0.0130373 -0.7606244 0.18995147 0.18860561 0.12667224 0.02237316 0.01673185 -0.5391861 0.2607667 0.21036667 0.23790000 0.02753333 0.8963277431 1.38355e-05 FALSE FALSE
ENST00000588679 ENSG00000141622 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF165 protein_coding protein_coding 0.7191819 0.9114414 0.5338723 0.06835246 0.0130373 -0.7606244 0.07281239 0.04682018 0.05613710 0.02804232 0.01630559 0.2190562 0.1037125 0.04746667 0.10523333 0.05776667 0.6222432366 1.38355e-05   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141622 E001 0.0000000       18 46326809 46326947 139 +      
ENSG00000141622 E002 0.1817044 0.0406250345 0.84472593   18 46333968 46334017 50 + 0.001 0.097 7.749
ENSG00000141622 E003 0.1817044 0.0406250345 0.84472593   18 46334018 46334027 10 + 0.000 0.097 9.732
ENSG00000141622 E004 0.4847352 0.1458938145 0.32343848 0.46676760 18 46334028 46334112 85 + 0.267 0.097 -1.761
ENSG00000141622 E005 1.5532672 0.0112141180 0.23096556 0.36363112 18 46334113 46334223 111 + 0.494 0.301 -1.080
ENSG00000141622 E006 1.4362071 0.0592785079 0.92820447 0.95879844 18 46334224 46334229 6 + 0.356 0.355 -0.010
ENSG00000141622 E007 6.8193887 0.0027065665 0.81188823 0.88065426 18 46334230 46334335 106 + 0.867 0.861 -0.023
ENSG00000141622 E008 2.7939134 0.1831212514 0.20797584 0.33606332 18 46334336 46335887 1552 + 0.682 0.454 -1.046
ENSG00000141622 E009 4.6717037 0.0040594697 0.69275165 0.79391029 18 46335888 46336628 741 + 0.753 0.720 -0.132
ENSG00000141622 E010 3.1698463 0.1075899523 0.46602132 0.60559692 18 46336629 46337127 499 + 0.683 0.569 -0.498
ENSG00000141622 E011 6.2863522 0.0031846001 0.51522260 0.64991861 18 46337128 46337647 520 + 0.753 0.861 0.426
ENSG00000141622 E012 1.6522545 0.0085821288 0.77987480 0.85850306 18 46433190 46433505 316 + 0.430 0.398 -0.176
ENSG00000141622 E013 2.2026532 0.0071167811 0.83669190 0.89786819 18 46435289 46435396 108 + 0.494 0.477 -0.082
ENSG00000141622 E014 0.0000000       18 46447447 46447562 116 +      
ENSG00000141622 E015 4.1300138 0.0047936737 0.15370283 0.26669725 18 46447563 46447692 130 + 0.784 0.603 -0.758
ENSG00000141622 E016 2.6884961 0.0083474574 0.03109749 0.07409729 18 46450296 46450349 54 + 0.719 0.398 -1.494
ENSG00000141622 E017 2.6927625 0.0061438432 0.03034928 0.07265718 18 46450350 46450400 51 + 0.719 0.398 -1.495
ENSG00000141622 E018 2.9109986 0.0055845090 0.14879975 0.26004615 18 46450704 46450799 96 + 0.682 0.478 -0.928
ENSG00000141622 E019 3.7496517 0.1368031814 0.35776805 0.50219008 18 46455974 46456067 94 + 0.718 0.591 -0.546
ENSG00000141622 E020 2.8295121 0.1978949750 0.98345673 0.99371665 18 46456068 46456080 13 + 0.493 0.565 0.338
ENSG00000141622 E021 54.5768850 0.0005311017 0.93741279 0.96464421 18 46456519 46460820 4302 + 1.693 1.723 0.101
ENSG00000141622 E022 40.5537602 0.0326844696 0.01715361 0.04528062 18 46460821 46463140 2320 + 1.423 1.655 0.796