ENSG00000141577

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269392 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 4.7140624 7.787477 2.6487554 1.2216773 0.21884073 -1.5522563 0.19397500 0.2049000 0.27170000 0.06680000 2.755255e-01 1.334206e-13 FALSE TRUE
ENST00000374782 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 3.0874442 5.148673 2.7472054 0.3492462 0.09912089 -0.9037934 0.14038750 0.1370333 0.28320000 0.14616667 8.776196e-07 1.334206e-13 FALSE TRUE
ENST00000450824 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 2.6309810 4.002381 0.0000000 0.8960547 0.00000000 -8.6483147 0.13077500 0.1077333 0.00000000 -0.10773333 1.533339e-10 1.334206e-13 FALSE TRUE
ENST00000570817 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 4.6242924 8.053761 1.5846894 0.7783214 0.17175509 -2.3381774 0.19535417 0.2178333 0.16353333 -0.05430000 5.532726e-01 1.334206e-13 FALSE TRUE
ENST00000571292 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 1.9204634 4.430556 0.7023698 2.4490170 0.37612629 -2.6400421 0.06625417 0.1080000 0.07093333 -0.03706667 9.680826e-01 1.334206e-13 FALSE FALSE
ENST00000573053 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 1.6870700 4.607343 0.0000000 0.4832837 0.00000000 -8.8509192 0.05366667 0.1256000 0.00000000 -0.12560000 1.334206e-13 1.334206e-13 FALSE TRUE
ENST00000575907 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding protein_coding 22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 0.5878799 0.000000 0.0000000 0.0000000 0.00000000 0.0000000 0.05095833 0.0000000 0.00000000 0.00000000   1.334206e-13 FALSE TRUE
MSTRG.15260.7 ENSG00000141577 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP131 protein_coding   22.52901 37.83041 9.721415 3.282439 0.2855329 -1.959206 2.1166970 2.210401 1.7007186 0.8243704 0.17381640 -0.3762179 0.11308333 0.0556000 0.17533333 0.11973333 7.915303e-03 1.334206e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141577 E001 1.141495 0.0186018731 6.900925e-01 7.918783e-01 17 81189593 81189595 3 - 0.216 0.297 0.609
ENSG00000141577 E002 2.687271 0.0057460556 1.407225e-01 2.490048e-01 17 81189596 81189596 1 - 0.216 0.519 1.835
ENSG00000141577 E003 34.404609 0.0066580592 5.419588e-04 2.316931e-03 17 81189597 81189647 51 - 1.143 1.479 1.175
ENSG00000141577 E004 172.871996 0.0046083500 5.395397e-05 3.015167e-04 17 81189648 81189826 179 - 1.948 2.151 0.681
ENSG00000141577 E005 115.633183 0.0020995475 3.126726e-05 1.852480e-04 17 81189827 81189843 17 - 1.766 1.979 0.716
ENSG00000141577 E006 33.470823 0.0107171236 1.508470e-01 2.628326e-01 17 81189844 81189914 71 - 1.308 1.446 0.478
ENSG00000141577 E007 145.492833 0.0015743004 8.515728e-06 5.749391e-05 17 81189915 81189975 61 - 1.876 2.076 0.671
ENSG00000141577 E008 80.496293 0.0026265594 6.707017e-05 3.659632e-04 17 81190639 81190649 11 - 1.584 1.828 0.826
ENSG00000141577 E009 256.164519 0.0002285791 2.850998e-07 2.650991e-06 17 81190650 81190802 153 - 2.157 2.312 0.518
ENSG00000141577 E010 297.567384 0.0008046611 6.483222e-03 1.988001e-02 17 81190907 81191084 178 - 2.283 2.364 0.270
ENSG00000141577 E011 267.147783 0.0002168044 4.831630e-01 6.212214e-01 17 81191193 81191332 140 - 2.289 2.307 0.062
ENSG00000141577 E012 96.190554 0.0036471432 2.336269e-01 3.667087e-01 17 81191333 81191335 3 - 1.918 1.858 -0.202
ENSG00000141577 E013 23.228322 0.0008688672 8.133353e-02 1.616423e-01 17 81191336 81191350 15 - 1.384 1.237 -0.513
ENSG00000141577 E014 153.155503 0.0002634913 6.003697e-01 7.216069e-01 17 81192318 81192392 75 - 2.051 2.069 0.061
ENSG00000141577 E015 158.593188 0.0002133426 1.609477e-01 2.763573e-01 17 81192476 81192593 118 - 2.039 2.089 0.167
ENSG00000141577 E016 89.101020 0.0003558562 2.277266e-03 8.082076e-03 17 81192736 81192843 108 - 1.699 1.854 0.526
ENSG00000141577 E017 190.351544 0.0021472669 2.203293e-01 3.508096e-01 17 81193926 81194127 202 - 2.116 2.165 0.165
ENSG00000141577 E018 133.264060 0.0062352137 1.895389e-01 3.131739e-01 17 81194870 81194972 103 - 1.941 2.016 0.253
ENSG00000141577 E019 129.861630 0.0002470871 9.219942e-01 9.547730e-01 17 81195835 81195951 117 - 1.990 1.993 0.009
ENSG00000141577 E020 135.179406 0.0011721705 4.741778e-02 1.045733e-01 17 81196701 81196826 126 - 1.938 2.024 0.287
ENSG00000141577 E021 143.094736 0.0002779215 2.037229e-03 7.342139e-03 17 81196930 81197055 126 - 1.932 2.054 0.411
ENSG00000141577 E022 171.635304 0.0002529980 3.957180e-01 5.395137e-01 17 81197712 81197888 177 - 2.137 2.107 -0.100
ENSG00000141577 E023 29.533948 0.0166119872 2.920089e-01 4.329422e-01 17 81198106 81198114 9 - 1.438 1.345 -0.324
ENSG00000141577 E024 165.024251 0.0015125833 1.268848e-02 3.517921e-02 17 81198115 81198297 183 - 2.170 2.077 -0.312
ENSG00000141577 E025 108.876412 0.0007996881 1.148177e-01 2.125618e-01 17 81198877 81198971 95 - 1.972 1.904 -0.230
ENSG00000141577 E026 144.312914 0.0003121638 2.742864e-03 9.500627e-03 17 81199381 81199549 169 - 2.124 2.016 -0.363
ENSG00000141577 E027 122.576601 0.0002641069 1.201807e-02 3.357252e-02 17 81199719 81199817 99 - 2.049 1.951 -0.329
ENSG00000141577 E028 71.116615 0.0004890167 6.707749e-02 1.385028e-01 17 81199818 81199835 18 - 1.816 1.722 -0.317
ENSG00000141577 E029 109.766378 0.0003238435 3.267736e-02 7.715813e-02 17 81200329 81200446 118 - 1.996 1.907 -0.298
ENSG00000141577 E030 169.453448 0.0010822667 3.550323e-06 2.614468e-05 17 81202240 81202398 159 - 2.238 2.076 -0.542
ENSG00000141577 E031 134.673258 0.0002501347 3.381502e-10 5.450654e-09 17 81203494 81203607 114 - 2.185 1.965 -0.738
ENSG00000141577 E032 1.223069 0.0291417451 1.215140e-02 3.389350e-02 17 81203868 81204071 204 - 0.626 0.174 -2.714
ENSG00000141577 E033 126.974698 0.0005180816 1.388421e-05 8.923910e-05 17 81206744 81206871 128 - 2.118 1.954 -0.551
ENSG00000141577 E034 116.545800 0.0028529310 3.026146e-02 7.248082e-02 17 81207125 81207239 115 - 2.031 1.930 -0.340
ENSG00000141577 E035 97.510325 0.0037308153 8.553668e-03 2.517386e-02 17 81208928 81209022 95 - 1.978 1.844 -0.453
ENSG00000141577 E036 113.074730 0.0046396865 1.706723e-03 6.303044e-03 17 81219880 81220073 194 - 2.059 1.902 -0.527
ENSG00000141577 E037 52.084083 0.0531351688 1.136950e-01 2.109120e-01 17 81222769 81222999 231 - 1.751 1.566 -0.630