ENSG00000141576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269391 ENSG00000141576 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF157 protein_coding protein_coding 14.99655 23.82435 10.44479 0.9020716 0.1059246 -1.188878 10.5192919 16.5421481 7.7113195 1.2326027 0.3198980 -1.100099 0.70954583 0.69246667 0.73873333 0.04626667 6.979306e-01 6.293872e-05 FALSE TRUE
ENST00000319945 ENSG00000141576 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF157 protein_coding protein_coding 14.99655 23.82435 10.44479 0.9020716 0.1059246 -1.188878 0.5860868 0.3285213 1.3885847 0.1233645 0.3306647 2.046649 0.05128750 0.01353333 0.13270000 0.11916667 6.293872e-05 6.293872e-05 FALSE TRUE
ENST00000592271 ENSG00000141576 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF157 protein_coding protein_coding 14.99655 23.82435 10.44479 0.9020716 0.1059246 -1.188878 0.8412874 1.9939505 0.3512084 0.1872910 0.1182891 -2.471943 0.04997500 0.08426667 0.03343333 -0.05083333 9.959124e-02 6.293872e-05 FALSE FALSE
ENST00000647930 ENSG00000141576 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF157 protein_coding protein_coding 14.99655 23.82435 10.44479 0.9020716 0.1059246 -1.188878 1.7832732 3.9453398 0.2091257 0.3134828 0.1233508 -4.173971 0.09651667 0.16676667 0.01990000 -0.14686667 1.476130e-02 6.293872e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141576 E001 6.7363493 0.0027812760 2.937177e-04 1.354230e-03 17 76142465 76142473 9 - 0.298 0.941 2.973
ENSG00000141576 E002 114.0994790 0.0207751242 2.828640e-04 1.309989e-03 17 76142474 76142632 159 - 1.726 2.078 1.185
ENSG00000141576 E003 75.0772963 0.0207069552 1.790841e-04 8.739779e-04 17 76142633 76142639 7 - 1.519 1.903 1.303
ENSG00000141576 E004 275.4276983 0.0149701783 3.790401e-05 2.197375e-04 17 76142640 76142846 207 - 2.140 2.451 1.039
ENSG00000141576 E005 927.6991295 0.0030521571 7.899967e-13 1.972878e-11 17 76142847 76144339 1493 - 2.737 2.963 0.750
ENSG00000141576 E006 176.7943626 0.0023557840 1.003969e-01 1.910740e-01 17 76144340 76144662 323 - 2.112 2.218 0.353
ENSG00000141576 E007 264.1196849 0.0019488378 4.389145e-01 5.807204e-01 17 76144663 76145014 352 - 2.317 2.385 0.228
ENSG00000141576 E008 193.9810260 0.0002025941 1.073729e-01 2.016663e-01 17 76145015 76145278 264 - 2.237 2.234 -0.009
ENSG00000141576 E009 82.7183906 0.0004035826 4.857148e-01 6.235477e-01 17 76145279 76145353 75 - 1.816 1.889 0.246
ENSG00000141576 E010 3.1699153 0.0081193890 1.958891e-02 5.060352e-02 17 76147269 76147309 41 - 0.174 0.648 2.806
ENSG00000141576 E011 100.3193623 0.0003231743 8.968620e-01 9.381160e-01 17 76152355 76152465 111 - 1.915 1.963 0.159
ENSG00000141576 E012 1.6230080 0.0127216944 5.541768e-01 6.831853e-01 17 76152466 76152583 118 - 0.298 0.434 0.800
ENSG00000141576 E013 2.0553024 0.0072801286 3.492195e-01 4.934483e-01 17 76154280 76154282 3 - 0.298 0.498 1.125
ENSG00000141576 E014 52.7161992 0.0004736448 7.407356e-01 8.300857e-01 17 76154283 76154301 19 - 1.656 1.680 0.081
ENSG00000141576 E015 56.2328456 0.0004377553 1.839703e-01 3.061948e-01 17 76154302 76154328 27 - 1.722 1.695 -0.090
ENSG00000141576 E016 60.4905656 0.0009151467 3.541566e-01 4.984244e-01 17 76155252 76155317 66 - 1.666 1.757 0.309
ENSG00000141576 E017 118.4933117 0.0003645058 1.567936e-01 2.708250e-01 17 76155562 76155734 173 - 2.031 2.022 -0.029
ENSG00000141576 E018 95.0449095 0.0003061472 2.163928e-03 7.732129e-03 17 76156210 76156321 112 - 1.985 1.907 -0.261
ENSG00000141576 E019 3.3579795 0.0046973274 5.229131e-01 6.566584e-01 17 76156322 76156370 49 - 0.648 0.579 -0.304
ENSG00000141576 E020 99.2650315 0.0010943452 1.508001e-02 4.066883e-02 17 76158393 76158501 109 - 1.987 1.930 -0.191
ENSG00000141576 E021 1.0684327 0.0122094498 1.986250e-02 5.119928e-02 17 76158502 76158523 22 - 0.539 0.155 -2.519
ENSG00000141576 E022 131.0647717 0.0003024233 6.881123e-04 2.855784e-03 17 76159335 76159573 239 - 2.117 2.046 -0.240
ENSG00000141576 E023 51.3665636 0.0004558324 3.401276e-03 1.144169e-02 17 76161535 76161561 27 - 1.746 1.635 -0.376
ENSG00000141576 E024 87.9744206 0.0006737573 3.152036e-04 1.441724e-03 17 76161562 76161647 86 - 1.969 1.862 -0.359
ENSG00000141576 E025 120.5453583 0.0084553753 7.176488e-03 2.168260e-02 17 76161843 76162002 160 - 2.104 2.003 -0.340
ENSG00000141576 E026 0.4427912 0.2066156829 2.191507e-01 3.493441e-01 17 76162003 76162145 143 - 0.298 0.084 -2.212
ENSG00000141576 E027 93.7100524 0.0020783501 3.386633e-05 1.988001e-04 17 76162552 76162623 72 - 2.017 1.879 -0.465
ENSG00000141576 E028 8.7054502 0.0020941957 5.884755e-03 1.830833e-02 17 76162761 76164747 1987 - 1.124 0.859 -0.983
ENSG00000141576 E029 80.1800133 0.0083495543 8.230308e-03 2.436832e-02 17 76164748 76164795 48 - 1.933 1.819 -0.384
ENSG00000141576 E030 85.6940751 0.0087334226 1.788497e-03 6.562695e-03 17 76165502 76165545 44 - 1.980 1.840 -0.472
ENSG00000141576 E031 103.7793207 0.0024457218 2.227462e-05 1.366093e-04 17 76166461 76166527 67 - 2.062 1.922 -0.468
ENSG00000141576 E032 122.3912095 0.0016589034 6.013088e-08 6.374358e-07 17 76167009 76167126 118 - 2.147 1.983 -0.550
ENSG00000141576 E033 125.3343200 0.0079048848 7.221021e-06 4.955627e-05 17 76167651 76167797 147 - 2.178 1.984 -0.650
ENSG00000141576 E034 91.0391109 0.0137118946 1.633521e-04 8.064044e-04 17 76173702 76173790 89 - 2.049 1.843 -0.690
ENSG00000141576 E035 25.6733909 0.0531094310 3.381895e-03 1.138458e-02 17 76211877 76212363 487 - 0.994 1.461 1.654
ENSG00000141576 E036 85.3031816 0.0064443443 5.762954e-05 3.197652e-04 17 76212364 76212482 119 - 2.000 1.823 -0.595
ENSG00000141576 E037 48.8777079 0.0120141057 2.739607e-04 1.273801e-03 17 76240153 76240493 341 - 1.789 1.567 -0.755