ENSG00000141569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269383 ENSG00000141569 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM65 protein_coding protein_coding 40.94434 60.44482 27.72176 4.597566 0.937172 -1.124318 29.375037 48.25005 16.688416 3.1733113 0.6265611 -1.5311182 0.6932292 0.79963333 0.60296667 -0.1966667 1.121592e-06 1.121592e-06 FALSE TRUE
ENST00000540812 ENSG00000141569 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM65 protein_coding retained_intron 40.94434 60.44482 27.72176 4.597566 0.937172 -1.124318 1.896583 1.62401 1.610852 0.2534151 0.1853713 -0.0116640 0.0509625 0.02656667 0.05786667 0.0313000 9.055082e-04 1.121592e-06 FALSE FALSE
ENST00000648382 ENSG00000141569 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM65 protein_coding processed_transcript 40.94434 60.44482 27.72176 4.597566 0.937172 -1.124318 7.257486 7.87291 6.007463 1.2755347 0.5866205 -0.3895729 0.1895292 0.12860000 0.21640000 0.0878000 1.349197e-02 1.121592e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141569 E001 3.630913 0.0084472848 2.322910e-05 1.418752e-04 17 75880304 75880334 31 - 0.982 0.376 -2.641
ENSG00000141569 E002 5.579728 0.0029440883 7.066109e-06 4.861499e-05 17 75880335 75880440 106 - 1.108 0.552 -2.207
ENSG00000141569 E003 3.093635 0.0050959506 1.558043e-02 4.180238e-02 17 75880441 75880443 3 - 0.804 0.443 -1.600
ENSG00000141569 E004 8.188529 0.0027883469 1.488180e-07 1.461693e-06 17 75880444 75880629 186 - 1.260 0.694 -2.127
ENSG00000141569 E005 1344.988448 0.0049573510 1.300789e-04 6.591697e-04 17 75888963 75889852 890 - 2.949 3.083 0.445
ENSG00000141569 E006 388.431425 0.0001678684 6.258726e-08 6.615504e-07 17 75889853 75889952 100 - 2.403 2.539 0.453
ENSG00000141569 E007 530.991113 0.0020604663 4.850249e-03 1.551534e-02 17 75889953 75890212 260 - 2.571 2.670 0.330
ENSG00000141569 E008 1203.022881 0.0004938258 4.652296e-01 6.049415e-01 17 75890213 75891022 810 - 2.996 3.006 0.033
ENSG00000141569 E009 331.827261 0.0006620960 2.924274e-01 4.333963e-01 17 75891023 75891179 157 - 2.412 2.456 0.146
ENSG00000141569 E010 253.505162 0.0003855381 6.078469e-01 7.277545e-01 17 75891180 75891276 97 - 2.326 2.328 0.009
ENSG00000141569 E011 281.240702 0.0017297424 1.101578e-02 3.119908e-02 17 75891277 75891347 71 - 2.417 2.359 -0.194
ENSG00000141569 E012 131.290240 0.0007105271 2.332055e-03 8.250094e-03 17 75891813 75891878 66 - 2.110 2.017 -0.313
ENSG00000141569 E013 307.651548 0.0009159278 3.019574e-04 1.387459e-03 17 75892011 75892185 175 - 2.467 2.391 -0.253
ENSG00000141569 E014 375.355449 0.0057499188 3.800912e-02 8.737035e-02 17 75892267 75892500 234 - 2.546 2.485 -0.203
ENSG00000141569 E015 27.583606 0.0007004203 1.280137e-04 6.501305e-04 17 75892501 75892539 39 - 1.562 1.312 -0.863
ENSG00000141569 E016 33.551918 0.0006624416 1.672110e-05 1.055533e-04 17 75892583 75892754 172 - 1.643 1.385 -0.886
ENSG00000141569 E017 163.668786 0.0059602022 4.601554e-03 1.482447e-02 17 75892755 75892850 96 - 2.227 2.112 -0.385
ENSG00000141569 E018 20.948526 0.0203100913 2.831370e-09 3.862010e-08 17 75896002 75896155 154 - 1.622 1.049 -2.003
ENSG00000141569 E019 180.118716 0.0078601276 3.177059e-04 1.451618e-03 17 75896524 75896951 428 - 2.300 2.139 -0.539