ENSG00000141564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306801 ENSG00000141564 HEK293_OSMI2_2hA HEK293_TMG_2hB RPTOR protein_coding protein_coding 20.05184 29.93586 16.29919 2.084918 0.1872127 -0.8766716 13.6509161 15.387202 13.793882 3.9092849 0.20825837 -0.1575941 0.72287917 0.5064333 0.846300000 0.33986667 1.138443e-02 3.971212e-12 FALSE TRUE
ENST00000544334 ENSG00000141564 HEK293_OSMI2_2hA HEK293_TMG_2hB RPTOR protein_coding protein_coding 20.05184 29.93586 16.29919 2.084918 0.1872127 -0.8766716 0.8007162 2.397311 0.114086 0.9154414 0.07541249 -4.2780096 0.03073750 0.0805000 0.006933333 -0.07356667 3.759950e-02 3.971212e-12 FALSE TRUE
ENST00000575542 ENSG00000141564 HEK293_OSMI2_2hA HEK293_TMG_2hB RPTOR protein_coding processed_transcript 20.05184 29.93586 16.29919 2.084918 0.1872127 -0.8766716 2.6080805 8.328198 0.000000 2.0094043 0.00000000 -9.7035919 0.09793333 0.2854667 0.000000000 -0.28546667 3.971212e-12 3.971212e-12 FALSE TRUE
MSTRG.15244.9 ENSG00000141564 HEK293_OSMI2_2hA HEK293_TMG_2hB RPTOR protein_coding   20.05184 29.93586 16.29919 2.084918 0.1872127 -0.8766716 1.1971558 1.678839 0.804011 0.2534480 0.10562403 -1.0529116 0.05497917 0.0565000 0.049200000 -0.00730000 8.516966e-01 3.971212e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141564 E001 0.0000000       17 80544724 80544806 83 +      
ENSG00000141564 E002 0.0000000       17 80544807 80544818 12 +      
ENSG00000141564 E003 0.0000000       17 80544819 80544830 12 +      
ENSG00000141564 E004 2.3938843 0.0857491643 1.861065e-01 3.088657e-01 17 80544831 80544837 7 + 0.636 0.408 -1.093
ENSG00000141564 E005 44.1581434 0.0004744225 5.837268e-15 1.988586e-13 17 80544838 80544873 36 + 1.840 1.463 -1.281
ENSG00000141564 E006 47.8388117 0.0004559242 3.630111e-16 1.451792e-14 17 80544874 80544876 3 + 1.875 1.496 -1.286
ENSG00000141564 E007 283.7151178 0.0036148835 3.588159e-09 4.798913e-08 17 80544877 80545467 591 + 2.531 2.363 -0.560
ENSG00000141564 E008 173.9586808 0.0065507424 2.271023e-03 8.062751e-03 17 80545468 80545665 198 + 2.281 2.178 -0.346
ENSG00000141564 E009 165.2618232 0.0105552645 1.522169e-02 4.098998e-02 17 80545666 80545791 126 + 2.254 2.160 -0.314
ENSG00000141564 E010 0.3697384 0.0249953964 4.007024e-01 5.443662e-01 17 80593244 80593805 562 + 0.000 0.179 15.739
ENSG00000141564 E011 138.8409077 0.0114959680 4.673791e-03 1.502241e-02 17 80625691 80625793 103 + 2.196 2.073 -0.412
ENSG00000141564 E012 129.9749082 0.0139972450 5.976273e-03 1.854536e-02 17 80643728 80643810 83 + 2.172 2.042 -0.435
ENSG00000141564 E013 160.2755417 0.0060213109 3.889223e-05 2.248403e-04 17 80707841 80707999 159 + 2.273 2.123 -0.502
ENSG00000141564 E014 0.5451131 0.6048907374 4.616184e-01 6.015449e-01 17 80708933 80709114 182 + 0.000 0.249 16.341
ENSG00000141564 E015 143.1092038 0.0041545330 3.048715e-03 1.040948e-02 17 80730560 80730706 147 + 2.187 2.099 -0.297
ENSG00000141564 E016 0.0000000       17 80743287 80743427 141 +      
ENSG00000141564 E017 152.0525252 0.0002762886 3.398006e-06 2.513537e-05 17 80754010 80754185 176 + 2.220 2.115 -0.351
ENSG00000141564 E018 3.2480792 0.1160120700 2.768305e-01 4.163072e-01 17 80754186 80755098 913 + 0.425 0.696 1.254
ENSG00000141564 E019 85.4685147 0.0036391079 9.167175e-02 1.777433e-01 17 80791450 80791509 60 + 1.935 1.890 -0.153
ENSG00000141564 E020 121.9042349 0.0003234205 9.814150e-04 3.896270e-03 17 80822201 80822301 101 + 2.109 2.033 -0.255
ENSG00000141564 E021 174.5737387 0.0067043618 2.370545e-02 5.920703e-02 17 80823079 80823223 145 + 2.260 2.194 -0.222
ENSG00000141564 E022 2.2906531 0.1268884867 5.179568e-01 6.522688e-01 17 80823224 80823620 397 + 0.352 0.529 0.932
ENSG00000141564 E023 127.1619681 0.0058483497 8.395173e-03 2.477669e-02 17 80837922 80837997 76 + 2.136 2.048 -0.294
ENSG00000141564 E024 135.8477250 0.0072899923 1.039742e-02 2.973985e-02 17 80846473 80846574 102 + 2.167 2.077 -0.301
ENSG00000141564 E025 124.0783056 0.0030195252 3.130296e-01 4.555495e-01 17 80855464 80855547 84 + 2.074 2.067 -0.023
ENSG00000141564 E026 166.6721234 0.0065221241 1.544009e-01 2.676195e-01 17 80857790 80857900 111 + 2.217 2.187 -0.100
ENSG00000141564 E027 0.0000000       17 80857901 80858124 224 +      
ENSG00000141564 E028 146.4989900 0.0041471404 9.425908e-02 1.817812e-01 17 80880415 80880489 75 + 2.162 2.128 -0.113
ENSG00000141564 E029 140.3961164 0.0017916876 1.584355e-01 2.730393e-01 17 80883419 80883484 66 + 2.130 2.114 -0.052
ENSG00000141564 E030 191.3702987 0.0005006675 1.623308e-02 4.323808e-02 17 80883781 80883972 192 + 2.275 2.242 -0.109
ENSG00000141564 E031 154.6748616 0.0019191407 1.238425e-01 2.254382e-01 17 80885008 80885148 141 + 2.177 2.158 -0.062
ENSG00000141564 E032 153.6384263 0.0019218721 3.104865e-02 7.400882e-02 17 80891720 80891837 118 + 2.188 2.148 -0.136
ENSG00000141564 E033 170.1182834 0.0017800693 2.076005e-02 5.308169e-02 17 80892729 80892869 141 + 2.234 2.191 -0.143
ENSG00000141564 E034 164.4721036 0.0003340656 6.658281e-01 7.734352e-01 17 80893707 80893865 159 + 2.175 2.197 0.072
ENSG00000141564 E035 130.3328717 0.0002635316 3.503246e-01 4.945145e-01 17 80908811 80908929 119 + 2.086 2.090 0.012
ENSG00000141564 E036 0.1817044 0.0394762376 8.226268e-01   17 80909554 80909867 314 + 0.000 0.099 14.739
ENSG00000141564 E037 130.8498688 0.0002534362 4.087699e-01 5.523870e-01 17 80922724 80922827 104 + 2.047 2.109 0.207
ENSG00000141564 E038 184.4698769 0.0015063685 9.455218e-01 9.698227e-01 17 80923490 80923673 184 + 2.210 2.249 0.132
ENSG00000141564 E039 0.5106578 0.2045784423 9.912048e-01 9.986321e-01 17 80923674 80924172 499 + 0.151 0.180 0.302
ENSG00000141564 E040 140.6945346 0.0031627918 8.252143e-02 1.634877e-01 17 80925370 80925480 111 + 2.141 2.109 -0.108
ENSG00000141564 E041 172.7632647 0.0020924436 8.205111e-02 1.627594e-01 17 80940496 80940601 106 + 2.226 2.202 -0.083
ENSG00000141564 E042 0.7697675 0.0274578641 6.400494e-01 7.533734e-01 17 80945567 80945666 100 + 0.151 0.247 0.886
ENSG00000141564 E043 189.7487690 0.0048819384 1.993967e-01 3.254875e-01 17 80945667 80945781 115 + 2.264 2.247 -0.056
ENSG00000141564 E044 203.4503105 0.0026527752 6.434097e-01 7.559712e-01 17 80947227 80947351 125 + 2.248 2.301 0.177
ENSG00000141564 E045 0.1817044 0.0394762376 8.226268e-01   17 80948550 80948659 110 + 0.000 0.099 14.739
ENSG00000141564 E046 184.9400727 0.0001989563 1.506302e-02 4.063224e-02 17 80949443 80949547 105 + 2.168 2.271 0.344
ENSG00000141564 E047 208.2656241 0.0002633699 1.930247e-04 9.340304e-04 17 80957624 80957730 107 + 2.195 2.332 0.455
ENSG00000141564 E048 237.5230972 0.0002182651 3.527437e-03 1.180571e-02 17 80960078 80960205 128 + 2.273 2.381 0.361
ENSG00000141564 E049 220.7160995 0.0014319351 1.842666e-02 4.806979e-02 17 80961394 80961480 87 + 2.243 2.353 0.365
ENSG00000141564 E050 273.1824899 0.0008825815 5.075285e-03 1.613652e-02 17 80962461 80962577 117 + 2.334 2.445 0.368
ENSG00000141564 E051 275.9805409 0.0007003751 1.150457e-03 4.472891e-03 17 80962928 80963057 130 + 2.331 2.450 0.399
ENSG00000141564 E052 1689.4405646 0.0081332199 2.456271e-10 4.049897e-09 17 80964262 80966371 2110 + 3.001 3.278 0.923