ENSG00000141542

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269347 ENSG00000141542 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB40B protein_coding protein_coding 21.25843 27.04218 21.19614 1.255877 0.5946086 -0.3512626 11.205477 15.63571 10.245623 0.7784967 0.3426923 -0.6093524 0.5276917 0.5780667 0.4835667 -0.09450000 0.00760194 0.004329282 FALSE  
ENST00000538809 ENSG00000141542 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB40B protein_coding protein_coding 21.25843 27.04218 21.19614 1.255877 0.5946086 -0.3512626 6.019538 7.86584 6.407022 0.6933084 0.5584945 -0.2955300 0.2781917 0.2901000 0.3028667 0.01276667 0.92341514 0.004329282 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141542 E001 1.2887571 0.0290926196 0.4067524515 0.550367338 17 82654973 82655036 64 - 0.257 0.409 0.956
ENSG00000141542 E002 14.0493154 0.0342381065 0.7638309030 0.847072956 17 82655037 82655667 631 - 1.191 1.141 -0.178
ENSG00000141542 E003 10.2344658 0.0018024566 0.0993969364 0.189565122 17 82655668 82656492 825 - 1.131 0.961 -0.623
ENSG00000141542 E004 15.6607863 0.0067145137 0.0799653542 0.159507586 17 82656493 82657066 574 - 1.292 1.127 -0.585
ENSG00000141542 E005 2.0982575 0.0071738396 0.0032579966 0.011026076 17 82657067 82657067 1 - 0.736 0.252 -2.499
ENSG00000141542 E006 479.4228716 0.0010066965 0.7244152805 0.817941423 17 82657068 82657705 638 - 2.659 2.664 0.016
ENSG00000141542 E007 176.2831560 0.0002312665 0.0507237491 0.110454857 17 82657706 82657792 87 - 2.262 2.208 -0.180
ENSG00000141542 E008 155.7444139 0.0009629523 0.3867137001 0.530882249 17 82657793 82657910 118 - 2.193 2.165 -0.094
ENSG00000141542 E009 42.0879684 0.0212381502 0.5824677617 0.706830030 17 82657911 82657914 4 - 1.645 1.595 -0.172
ENSG00000141542 E010 101.8466128 0.0107230706 0.9945712200 1.000000000 17 82657915 82657976 62 - 1.991 1.989 -0.006
ENSG00000141542 E011 164.5619505 0.0005141620 0.4279089099 0.570735009 17 82657977 82658134 158 - 2.183 2.205 0.072
ENSG00000141542 E012 4.9373335 0.0577917120 0.2946372000 0.435748953 17 82658135 82658490 356 - 0.848 0.675 -0.696
ENSG00000141542 E013 104.6931959 0.0003152489 0.0220768904 0.055839795 17 82658491 82658562 72 - 1.950 2.030 0.270
ENSG00000141542 E014 142.1731552 0.0010679012 0.1156320365 0.213741401 17 82658563 82658713 151 - 2.101 2.151 0.167
ENSG00000141542 E015 11.1162915 0.0020423887 0.0015707577 0.005864131 17 82658714 82659579 866 - 1.245 0.934 -1.124
ENSG00000141542 E016 125.0897246 0.0004433251 0.2501566890 0.386118678 17 82659580 82659657 78 - 2.059 2.095 0.121
ENSG00000141542 E017 2.7345030 0.0055143208 0.8736135425 0.922765209 17 82659658 82659759 102 - 0.534 0.559 0.114
ENSG00000141542 E018 81.4237742 0.0003732804 0.3619957445 0.506398433 17 82660987 82661010 24 - 1.875 1.910 0.118
ENSG00000141542 E019 90.4527092 0.0030480073 0.4667084623 0.606261604 17 82661011 82661047 37 - 1.919 1.950 0.105
ENSG00000141542 E020 6.8772219 0.0075332656 0.0012873819 0.004934624 17 82661081 82661270 190 - 1.090 0.693 -1.523
ENSG00000141542 E021 103.2765620 0.0004182190 0.4616507089 0.601571855 17 82664496 82664556 61 - 2.014 1.986 -0.094
ENSG00000141542 E022 0.2965864 0.1332001791 0.3807205639   17 82664557 82664895 339 - 0.001 0.181 8.515
ENSG00000141542 E023 23.1722457 0.0017761807 0.0002705947 0.001260099 17 82696389 82696853 465 - 1.156 1.447 1.018
ENSG00000141542 E024 0.0000000       17 82696854 82696870 17 -      
ENSG00000141542 E025 143.3368003 0.0070633078 0.4308969220 0.573500978 17 82698455 82698698 244 - 2.164 2.121 -0.144