ENSG00000141519

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269318 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding protein_coding 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.92526500 1.44666613 0.3932489 0.05838582 0.14416506 -1.85292776 0.215775000 0.31870000 0.12246667 -0.19623333 0.05783044 0.02492237 FALSE TRUE
ENST00000374876 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding protein_coding 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.38795008 0.49440651 0.2297040 0.09325027 0.08098386 -1.07333271 0.089241667 0.11106667 0.06776667 -0.04330000 0.57302091 0.02492237 FALSE TRUE
ENST00000572083 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding retained_intron 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.31703292 0.19611266 0.2233890 0.02331661 0.13307801 0.17930353 0.084500000 0.04293333 0.06386667 0.02093333 1.00000000 0.02492237 FALSE TRUE
ENST00000573474 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding nonsense_mediated_decay 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.03638563 0.00000000 0.2910850 0.00000000 0.29108501 4.91209898 0.009233333 0.00000000 0.07386667 0.07386667 0.77298053 0.02492237 FALSE FALSE
ENST00000574099 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding protein_coding 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.16683036 0.05207242 0.3723378 0.05207242 0.12848482 2.62282370 0.040866667 0.01033333 0.10580000 0.09546667 0.02492237 0.02492237 FALSE FALSE
ENST00000574799 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding retained_intron 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.38724340 0.30216083 0.1604326 0.04451375 0.08564084 -0.87308853 0.090145833 0.06626667 0.04526667 -0.02100000 0.72729111 0.02492237 FALSE TRUE
ENST00000574933 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding retained_intron 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.43208099 0.61741432 0.1663446 0.11071596 0.16634462 -1.83102087 0.096654167 0.13760000 0.04223333 -0.09536667 0.23076924 0.02492237   FALSE
ENST00000576241 ENSG00000141519 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC40 protein_coding retained_intron 4.263787 4.547545 3.387587 0.2503764 0.3030291 -0.4237463 0.55435572 0.40483244 0.4211322 0.31562676 0.10629871 0.05560171 0.121875000 0.08280000 0.13163333 0.04883333 0.65663523 0.02492237 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141519 E001 2.9014467 0.0083315669 0.502265601 0.638323129 17 80036608 80036631 24 + 0.632 0.522 -0.495
ENSG00000141519 E002 2.7499313 0.0176269805 0.706508984 0.804644817 17 80036632 80036635 4 + 0.588 0.523 -0.300
ENSG00000141519 E003 2.7499313 0.0176269805 0.706508984 0.804644817 17 80036636 80036641 6 + 0.588 0.523 -0.300
ENSG00000141519 E004 2.3467817 0.0079588791 0.406476952 0.550120092 17 80036642 80036651 10 + 0.588 0.449 -0.666
ENSG00000141519 E005 3.8989175 0.0043531266 0.133736031 0.239340713 17 80036652 80036657 6 + 0.802 0.584 -0.909
ENSG00000141519 E006 4.6675536 0.0049454243 0.166434222 0.283562639 17 80036658 80036660 3 + 0.854 0.664 -0.768
ENSG00000141519 E007 4.6675536 0.0049454243 0.166434222 0.283562639 17 80036661 80036663 3 + 0.854 0.664 -0.768
ENSG00000141519 E008 6.8314083 0.0223758318 0.818873320 0.885569011 17 80036664 80036676 13 + 0.901 0.871 -0.117
ENSG00000141519 E009 7.9655296 0.0530745934 0.931492824 0.960843521 17 80036677 80036691 15 + 0.944 0.938 -0.023
ENSG00000141519 E010 0.7771569 0.0144339994 0.062613770 0.131048768 17 80036692 80036757 66 + 0.422 0.100 -2.668
ENSG00000141519 E011 0.2934659 0.0292226439 0.738732036   17 80037952 80038028 77 + 0.149 0.100 -0.670
ENSG00000141519 E012 13.0929280 0.0413106372 0.241387705 0.375804748 17 80038123 80038186 64 + 1.220 1.079 -0.502
ENSG00000141519 E013 22.1125683 0.0142752917 0.170436407 0.288728565 17 80039812 80040004 193 + 1.422 1.301 -0.419
ENSG00000141519 E014 10.0515373 0.0019121334 0.857599951 0.912069846 17 80040005 80040040 36 + 1.035 1.013 -0.083
ENSG00000141519 E015 28.3705993 0.0007955203 0.520339858 0.654317286 17 80040041 80040270 230 + 1.422 1.461 0.133
ENSG00000141519 E016 1.7036367 0.0115891406 0.484226684 0.622237923 17 80040271 80040535 265 + 0.485 0.360 -0.666
ENSG00000141519 E017 12.5682288 0.0023139242 0.089831401 0.174865801 17 80047279 80047308 30 + 1.001 1.167 0.600
ENSG00000141519 E018 15.7800801 0.0012347858 0.239430889 0.373458015 17 80047309 80047402 94 + 1.137 1.237 0.355
ENSG00000141519 E019 1.9510190 0.0074877443 0.438707893 0.580564654 17 80047403 80047454 52 + 0.539 0.406 -0.668
ENSG00000141519 E020 2.5347270 0.0063354135 0.661270048 0.769747444 17 80048370 80048582 213 + 0.484 0.554 0.332
ENSG00000141519 E021 24.3690237 0.0008744565 0.644112954 0.756485224 17 80048583 80048761 179 + 1.365 1.394 0.100
ENSG00000141519 E022 16.5563662 0.0011938501 0.438901421 0.580711235 17 80049906 80049989 84 + 1.175 1.237 0.223
ENSG00000141519 E023 29.0874181 0.0008021709 0.104926641 0.197984475 17 80050064 80050283 220 + 1.380 1.484 0.358
ENSG00000141519 E024 26.4716867 0.0009006728 0.029322676 0.070627858 17 80058494 80058651 158 + 1.316 1.464 0.515
ENSG00000141519 E025 17.0534554 0.0010979134 0.064215710 0.133724730 17 80058858 80058924 67 + 1.124 1.280 0.555
ENSG00000141519 E026 15.6601096 0.0013911111 0.033673959 0.079106076 17 80058925 80058980 56 + 1.067 1.256 0.676
ENSG00000141519 E027 18.3507944 0.0011561677 0.126935969 0.229885557 17 80065485 80065606 122 + 1.175 1.298 0.435
ENSG00000141519 E028 8.7504699 0.0094794868 0.292646399 0.433620497 17 80066083 80066770 688 + 0.879 1.002 0.463
ENSG00000141519 E029 3.1896100 0.0077714736 0.013727332 0.037602687 17 80066874 80067504 631 + 0.260 0.689 2.243
ENSG00000141519 E030 8.5715559 0.0020288280 0.002040187 0.007351683 17 80067505 80067901 397 + 0.671 1.054 1.484
ENSG00000141519 E031 0.1817044 0.0397070512 0.729922322   17 80081443 80081545 103 + 0.000 0.100 10.586
ENSG00000141519 E032 11.0931556 0.0178789898 0.022806109 0.057339734 17 80081546 80081789 244 + 1.209 0.944 -0.960
ENSG00000141519 E033 2.2572695 0.0680397602 0.960702937 0.979254535 17 80081790 80081875 86 + 0.485 0.489 0.019
ENSG00000141519 E034 10.2232799 0.0024750438 0.012206048 0.034025385 17 80081876 80082058 183 + 1.175 0.916 -0.947
ENSG00000141519 E035 14.7433174 0.0012775662 0.278404767 0.418093776 17 80084743 80084988 246 + 1.241 1.143 -0.346
ENSG00000141519 E036 11.9549500 0.0015167634 0.560449333 0.688455846 17 80086003 80086216 214 + 1.124 1.064 -0.217
ENSG00000141519 E037 5.5140505 0.0031760022 0.007665917 0.022942166 17 80086217 80087513 1297 + 0.983 0.639 -1.360
ENSG00000141519 E038 1.0706228 0.0119972038 0.084147592 0.166048735 17 80087514 80087606 93 + 0.484 0.181 -1.991
ENSG00000141519 E039 7.9746634 0.0252757945 0.798547198 0.871457289 17 80087607 80087702 96 + 0.944 0.906 -0.145
ENSG00000141519 E040 6.2105471 0.0309895556 0.986663165 0.995735036 17 80087703 80087776 74 + 0.829 0.828 -0.006
ENSG00000141519 E041 0.3697384 0.0250423451 0.351662916 0.495902194 17 80087777 80087826 50 + 0.000 0.181 11.530
ENSG00000141519 E042 0.6653823 0.0171128700 0.146968822 0.257555709 17 80087827 80088010 184 + 0.348 0.100 -2.251
ENSG00000141519 E043 6.6349190 0.0611108114 0.292013690 0.432942210 17 80088011 80088102 92 + 0.965 0.791 -0.665
ENSG00000141519 E044 2.1193714 0.1501427639 0.975353074 0.988639514 17 80088103 80088104 2 + 0.486 0.482 -0.016
ENSG00000141519 E045 4.2260428 0.1254298714 0.607221193 0.727253512 17 80088105 80088189 85 + 0.633 0.730 0.409
ENSG00000141519 E046 2.5225210 0.0553620767 0.690592092 0.792250881 17 80088190 80088212 23 + 0.485 0.553 0.326
ENSG00000141519 E047 2.0698516 0.8470246000 0.784038043 0.861479176 17 80088297 80088394 98 + 0.421 0.514 0.470
ENSG00000141519 E048 0.1482932 0.0417016555 0.730974642   17 80089574 80089763 190 + 0.000 0.100 10.580
ENSG00000141519 E049 5.1024924 0.0036339960 0.075421983 0.152196038 17 80089764 80089884 121 + 0.902 0.664 -0.948
ENSG00000141519 E050 1.4737724 0.0095217180 0.316911011 0.459721892 17 80090139 80090819 681 + 0.484 0.308 -0.989
ENSG00000141519 E051 0.1472490 0.0423326647 0.317713122   17 80092079 80092145 67 + 0.149 0.000 -12.510
ENSG00000141519 E052 2.9484752 0.0053680178 0.343773517 0.487837007 17 80095263 80095267 5 + 0.671 0.522 -0.668
ENSG00000141519 E053 7.3685171 0.0023867305 0.562423558 0.690021969 17 80095268 80095451 184 + 0.944 0.873 -0.272
ENSG00000141519 E054 6.2236084 0.0028258214 0.251148723 0.387315393 17 80097245 80097403 159 + 0.741 0.887 0.573
ENSG00000141519 E055 1.0027668 0.0147511997 0.783932311 0.861398569 17 80097404 80097934 531 + 0.260 0.308 0.331
ENSG00000141519 E056 15.4698205 0.0037614977 0.161082288 0.276530698 17 80099527 80100613 1087 + 1.270 1.144 -0.449