ENSG00000141505

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269299 ENSG00000141505 HEK293_OSMI2_2hA HEK293_TMG_2hB ASGR1 protein_coding protein_coding 1.000648 1.75768 0.6283279 0.2377391 0.06115839 -1.469487 0.33902745 0.4303616 0.11531760 0.215638288 0.11531760 -1.8130997 0.36311667 0.280600000 0.22736667 -0.05323333 0.73021758 0.01609953 FALSE TRUE
ENST00000380920 ENSG00000141505 HEK293_OSMI2_2hA HEK293_TMG_2hB ASGR1 protein_coding protein_coding 1.000648 1.75768 0.6283279 0.2377391 0.06115839 -1.469487 0.12098480 0.2809122 0.33455150 0.280912182 0.16836833 0.2441359 0.12897500 0.136833333 0.48516667 0.34833333 0.42009065 0.01609953 FALSE TRUE
ENST00000570576 ENSG00000141505 HEK293_OSMI2_2hA HEK293_TMG_2hB ASGR1 protein_coding protein_coding 1.000648 1.75768 0.6283279 0.2377391 0.06115839 -1.469487 0.15772275 0.3772727 0.00000000 0.190407647 0.00000000 -5.2752779 0.11701667 0.189933333 0.00000000 -0.18993333 0.30015115 0.01609953   FALSE
ENST00000572879 ENSG00000141505 HEK293_OSMI2_2hA HEK293_TMG_2hB ASGR1 protein_coding protein_coding 1.000648 1.75768 0.6283279 0.2377391 0.06115839 -1.469487 0.06699494 0.1665727 0.00000000 0.083385654 0.00000000 -4.1421906 0.05447500 0.108400000 0.00000000 -0.10840000 0.34338155 0.01609953   FALSE
ENST00000573596 ENSG00000141505 HEK293_OSMI2_2hA HEK293_TMG_2hB ASGR1 protein_coding retained_intron 1.000648 1.75768 0.6283279 0.2377391 0.06115839 -1.469487 0.04787795 0.0123529 0.07773524 0.006555526 0.01314106 1.9726940 0.07532083 0.007666667 0.12503333 0.11736667 0.01609953 0.01609953 TRUE TRUE
ENST00000574330 ENSG00000141505 HEK293_OSMI2_2hA HEK293_TMG_2hB ASGR1 protein_coding protein_coding 1.000648 1.75768 0.6283279 0.2377391 0.06115839 -1.469487 0.18092633 0.3415116 0.05232875 0.080554634 0.02756746 -2.4956025 0.17941667 0.188633333 0.09283333 -0.09580000 0.39240869 0.01609953 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141505 E001 0.0000000       17 7173431 7173433 3 -      
ENSG00000141505 E002 2.4678029 0.089111107 0.6335351694 0.74821954 17 7173434 7173552 119 - 0.418 0.521 0.520
ENSG00000141505 E003 2.2860985 0.156651642 0.7547107547 0.84026427 17 7173553 7173557 5 - 0.418 0.493 0.382
ENSG00000141505 E004 4.7383226 0.006375408 0.8543694779 0.90989326 17 7173558 7173658 101 - 0.679 0.709 0.126
ENSG00000141505 E005 10.6698849 0.004865080 0.9477228374 0.97111821 17 7173659 7173833 175 - 0.984 0.993 0.036
ENSG00000141505 E006 1.0684302 0.012780840 0.5711056610 0.69746497 17 7173834 7173878 45 - 0.187 0.297 0.864
ENSG00000141505 E007 1.8779385 0.012312003 0.6286467713 0.74415897 17 7173879 7173960 82 - 0.318 0.411 0.546
ENSG00000141505 E008 11.6046093 0.001648599 0.7643607281 0.84746209 17 7173961 7174067 107 - 1.007 1.042 0.126
ENSG00000141505 E009 11.8678096 0.001944534 0.3010811756 0.44284880 17 7174138 7174289 152 - 0.959 1.071 0.415
ENSG00000141505 E010 5.2462365 0.007579628 0.1703898944 0.28867359 17 7174374 7174423 50 - 0.568 0.785 0.916
ENSG00000141505 E011 4.2216867 0.010358386 0.2207092326 0.35126543 17 7174424 7174460 37 - 0.499 0.708 0.929
ENSG00000141505 E012 0.5953508 0.020963648 0.3182799577 0.46125212 17 7176614 7176829 216 - 0.318 0.144 -1.462
ENSG00000141505 E013 2.7062886 0.008104677 0.6702349545 0.77672291 17 7176830 7176831 2 - 0.568 0.499 -0.322
ENSG00000141505 E014 5.0980094 0.005283623 0.0597599131 0.12621052 17 7176832 7176901 70 - 0.904 0.656 -0.990
ENSG00000141505 E015 6.2927226 0.002999643 0.2398799445 0.37400140 17 7176981 7177046 66 - 0.904 0.757 -0.573
ENSG00000141505 E016 5.3265020 0.004568006 0.1703340224 0.28860390 17 7177047 7177076 30 - 0.874 0.692 -0.722
ENSG00000141505 E017 1.1813402 0.011095790 0.0003025678 0.00138996 17 7177077 7177209 133 - 0.679 0.078 -4.267
ENSG00000141505 E018 4.6611302 0.051168625 0.3736099144 0.51802855 17 7177210 7177326 117 - 0.568 0.726 0.680
ENSG00000141505 E019 2.7477637 0.044586991 0.0565219156 0.12063481 17 7177327 7177482 156 - 0.187 0.576 2.360
ENSG00000141505 E020 1.6814985 0.390198107 0.7795586867 0.85826977 17 7177483 7177631 149 - 0.317 0.389 0.432
ENSG00000141505 E021 0.4847352 0.165926890 0.1881687437 0.31142604 17 7177632 7178084 453 - 0.318 0.078 -2.459
ENSG00000141505 E022 0.4847352 0.165926890 0.1881687437 0.31142604 17 7178085 7178116 32 - 0.318 0.078 -2.459
ENSG00000141505 E023 1.6835008 0.259654723 0.8042850082 0.87549904 17 7178117 7178493 377 - 0.318 0.408 0.529
ENSG00000141505 E024 0.6599951 0.019120712 0.2472362763 0.38268043 17 7178494 7178588 95 - 0.000 0.251 11.140
ENSG00000141505 E025 0.7479104 0.462112725 0.5621019882 0.68977133 17 7178589 7178899 311 - 0.319 0.192 -0.962
ENSG00000141505 E026 0.5546650 0.021982951 0.7875241405 0.86391326 17 7178900 7179189 290 - 0.187 0.144 -0.456
ENSG00000141505 E027 0.5503986 0.022196347 0.7862729949 0.86310390 17 7179190 7179355 166 - 0.187 0.144 -0.456
ENSG00000141505 E028 0.2214452 0.039528251 1.0000000000   17 7179356 7179356 1 - 0.000 0.078 9.472
ENSG00000141505 E029 0.2214452 0.039528251 1.0000000000   17 7179357 7179370 14 - 0.000 0.078 9.472
ENSG00000141505 E030 0.2214452 0.039528251 1.0000000000   17 7179371 7179376 6 - 0.000 0.078 9.472
ENSG00000141505 E031 0.3729606 0.028270628 0.4586779874 0.59898373 17 7179377 7179564 188 - 0.187 0.078 -1.456