ENSG00000141503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355280 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding protein_coding 29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 5.9429816 3.29344544 3.7090728 1.81291991 1.4130621 0.1709715 0.20649167 0.12630000 0.18246667 0.056166667 0.8201399714 4.523939e-06 FALSE  
ENST00000453408 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding protein_coding 29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 2.1950042 4.60573387 1.2882373 1.83935266 0.6465147 -1.8300059 0.07183333 0.15193333 0.06360000 -0.088333333 0.6187231834 4.523939e-06 FALSE  
ENST00000572304 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding retained_intron 29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 2.2538274 0.90312682 2.0700385 0.20635176 0.4675008 1.1877231 0.07707917 0.03046667 0.10026667 0.069800000 0.0037573540 4.523939e-06 FALSE  
ENST00000574871 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding retained_intron 29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 1.7802577 1.18723336 1.2009660 0.08862159 0.1854077 0.0164540 0.06087083 0.04146667 0.05910000 0.017633333 0.4654494829 4.523939e-06 FALSE  
ENST00000576037 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding protein_coding 29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 2.2604899 2.43802801 0.7637777 0.13636042 0.5064214 -1.6616291 0.06992500 0.08493333 0.03563333 -0.049300000 0.4672029006 4.523939e-06 FALSE  
MSTRG.13476.11 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding   29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 1.6085819 3.04141991 0.0000000 2.05283516 0.0000000 -8.2533369 0.05939583 0.11443333 0.00000000 -0.114433333 0.2111963333 4.523939e-06 FALSE  
MSTRG.13476.3 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding   29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 2.1090814 3.98737574 2.6799131 2.02421196 0.5923084 -0.5714936 0.07465833 0.13113333 0.13286667 0.001733333 0.9064799479 4.523939e-06 FALSE  
MSTRG.13476.4 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding   29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 5.3974948 6.29804258 3.6915055 2.43425694 0.7202732 -0.7690802 0.17874583 0.21033333 0.17826667 -0.032066667 0.9999652284 4.523939e-06 FALSE  
MSTRG.13476.6 ENSG00000141503 HEK293_OSMI2_2hA HEK293_TMG_2hB MINK1 protein_coding   29.37554 28.92087 20.46597 2.507483 0.7669588 -0.498678 0.5936755 0.06006855 1.1057478 0.03574872 0.3404288 3.9931001 0.02382500 0.00190000 0.05493333 0.053033333 0.0001276898 4.523939e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141503 E001 0.4762024 0.1597639999 3.531998e-01 4.974374e-01 17 4833340 4833346 7 + 0.262 0.099 -1.695
ENSG00000141503 E002 1.9133294 0.0111921412 4.385452e-02 9.811760e-02 17 4833347 4833365 19 + 0.635 0.306 -1.698
ENSG00000141503 E003 2.7206622 0.0340547880 3.814755e-02 8.763469e-02 17 4833366 4833372 7 + 0.745 0.404 -1.570
ENSG00000141503 E004 15.4142196 0.0557214004 6.657393e-01 7.733769e-01 17 4833373 4833392 20 + 1.213 1.181 -0.112
ENSG00000141503 E005 20.1526570 0.0595027988 7.937652e-01 8.681741e-01 17 4833393 4833398 6 + 1.302 1.302 0.000
ENSG00000141503 E006 21.2888546 0.0688549268 8.487837e-01 9.061288e-01 17 4833399 4833399 1 + 1.319 1.328 0.030
ENSG00000141503 E007 28.6592208 0.0761033967 7.600144e-01 8.442292e-01 17 4833400 4833412 13 + 1.446 1.450 0.014
ENSG00000141503 E008 75.9814668 0.0260309219 1.683100e-01 2.860022e-01 17 4833413 4833583 171 + 1.917 1.828 -0.300
ENSG00000141503 E009 43.5249461 0.0095196976 1.013614e-01 1.925460e-01 17 4833584 4833600 17 + 1.680 1.585 -0.322
ENSG00000141503 E010 50.2451109 0.0040710446 1.714276e-02 4.525702e-02 17 4833601 4833620 20 + 1.756 1.635 -0.409
ENSG00000141503 E011 48.6212056 0.0042408464 4.165468e-04 1.837806e-03 17 4833621 4833640 20 + 1.783 1.594 -0.642
ENSG00000141503 E012 1.5467976 0.0136125934 2.762393e-01 4.156721e-01 17 4859213 4859328 116 + 0.487 0.306 -1.017
ENSG00000141503 E013 82.4863938 0.0039160011 2.198653e-05 1.349953e-04 17 4878317 4878382 66 + 2.007 1.819 -0.634
ENSG00000141503 E014 99.2092572 0.0045902571 7.259817e-05 3.926544e-04 17 4880984 4881040 57 + 2.076 1.906 -0.571
ENSG00000141503 E015 0.8836053 0.0152439038 8.999856e-01 9.401965e-01 17 4881114 4881131 18 + 0.262 0.247 -0.112
ENSG00000141503 E016 154.3823740 0.0022097905 4.067296e-06 2.952589e-05 17 4881132 4881257 126 + 2.253 2.106 -0.491
ENSG00000141503 E017 147.0876100 0.0003150801 7.096613e-05 3.848602e-04 17 4884363 4884468 106 + 2.205 2.101 -0.348
ENSG00000141503 E018 74.4047979 0.0043782112 2.223700e-02 5.616901e-02 17 4884469 4884473 5 + 1.911 1.812 -0.332
ENSG00000141503 E019 129.2874291 0.0004855175 2.593698e-03 9.046473e-03 17 4884912 4885002 91 + 2.137 2.054 -0.275
ENSG00000141503 E020 138.2222006 0.0003365998 2.731182e-05 1.640606e-04 17 4885483 4885613 131 + 2.187 2.073 -0.382
ENSG00000141503 E021 90.5309338 0.0008601601 1.843332e-04 8.964081e-04 17 4885911 4885965 55 + 2.015 1.884 -0.440
ENSG00000141503 E022 108.0028846 0.0067588906 4.036581e-02 9.168843e-02 17 4886120 4886198 79 + 2.062 1.978 -0.282
ENSG00000141503 E023 82.0699632 0.0120426356 1.112933e-01 2.074522e-01 17 4886451 4886493 43 + 1.938 1.862 -0.257
ENSG00000141503 E024 150.2282570 0.0032727900 4.507789e-04 1.969573e-03 17 4886494 4886617 124 + 2.224 2.106 -0.396
ENSG00000141503 E025 79.3202584 0.0003290252 4.522054e-06 3.252058e-05 17 4886618 4886626 9 + 1.980 1.812 -0.565
ENSG00000141503 E026 129.6904163 0.0002438546 2.709043e-06 2.048456e-05 17 4887110 4887179 70 + 2.170 2.037 -0.444
ENSG00000141503 E027 142.1642759 0.0002766229 2.568988e-05 1.552926e-04 17 4887580 4887790 211 + 2.197 2.084 -0.376
ENSG00000141503 E028 81.1982663 0.0006832901 5.364499e-01 6.682063e-01 17 4889647 4889763 117 + 1.854 1.898 0.147
ENSG00000141503 E029 6.6228906 0.0025811616 2.652087e-04 1.238030e-03 17 4889764 4890221 458 + 1.086 0.661 -1.645
ENSG00000141503 E030 5.5950550 0.0028594157 7.289341e-03 2.197346e-02 17 4890222 4890308 87 + 0.987 0.661 -1.283
ENSG00000141503 E031 12.8922410 0.0013739481 4.377155e-07 3.916122e-06 17 4890309 4890516 208 + 1.361 0.911 -1.619
ENSG00000141503 E032 106.0752454 0.0012470696 3.642561e-01 5.086253e-01 17 4890517 4890735 219 + 1.961 2.015 0.183
ENSG00000141503 E033 99.8610570 0.0003238559 9.591854e-02 1.842633e-01 17 4890951 4891124 174 + 1.920 2.000 0.269
ENSG00000141503 E034 60.6571343 0.0012740328 3.557655e-01 5.001165e-01 17 4891456 4891515 60 + 1.723 1.786 0.213
ENSG00000141503 E035 71.0034224 0.0003652689 7.262346e-02 1.477147e-01 17 4891516 4891558 43 + 1.762 1.859 0.328
ENSG00000141503 E036 148.2454702 0.0003034698 1.314141e-01 2.361199e-01 17 4891559 4891716 158 + 2.097 2.162 0.217
ENSG00000141503 E037 115.8231781 0.0003964117 1.992187e-01 3.252531e-01 17 4892149 4892234 86 + 1.991 2.054 0.212
ENSG00000141503 E038 73.7308630 0.0003767069 8.025738e-01 8.742442e-01 17 4892402 4892470 69 + 1.836 1.842 0.020
ENSG00000141503 E039 62.4580044 0.0042741176 6.724602e-01 7.784182e-01 17 4892471 4892512 42 + 1.739 1.785 0.152
ENSG00000141503 E040 120.9438627 0.0040220525 7.481072e-01 8.354456e-01 17 4892656 4892768 113 + 2.050 2.058 0.028
ENSG00000141503 E041 145.1901495 0.0012918009 8.927926e-01 9.354761e-01 17 4892979 4893067 89 + 2.127 2.141 0.045
ENSG00000141503 E042 4.4432388 0.0507303231 2.358362e-01 3.693657e-01 17 4893068 4893195 128 + 0.833 0.657 -0.717
ENSG00000141503 E043 6.2814165 0.0288794679 2.551456e-03 8.916378e-03 17 4893196 4893285 90 + 1.071 0.659 -1.597
ENSG00000141503 E044 5.3989545 0.0040991364 4.619211e-03 1.487398e-02 17 4893286 4893309 24 + 0.987 0.635 -1.391
ENSG00000141503 E045 6.4768399 0.0874433855 4.292306e-03 1.396167e-02 17 4893310 4893433 124 + 1.115 0.629 -1.884
ENSG00000141503 E046 187.1270021 0.0007202895 4.949535e-01 6.318433e-01 17 4893434 4893577 144 + 2.220 2.258 0.127
ENSG00000141503 E047 89.8883665 0.0128134421 1.826235e-01 3.044883e-01 17 4893578 4893597 20 + 1.856 1.966 0.369
ENSG00000141503 E048 22.0398928 0.0012815762 8.817180e-11 1.570947e-09 17 4893598 4893987 390 + 1.579 1.115 -1.618
ENSG00000141503 E049 55.6700793 0.0065790378 9.780031e-01 9.903665e-01 17 4893988 4893990 3 + 1.712 1.730 0.059
ENSG00000141503 E050 157.0171889 0.0015865509 1.947827e-01 3.197299e-01 17 4893991 4894093 103 + 2.125 2.190 0.218
ENSG00000141503 E051 197.7942381 0.0008552734 4.991415e-01 6.354811e-01 17 4894174 4894311 138 + 2.244 2.282 0.127
ENSG00000141503 E052 96.1669578 0.0030551600 2.620737e-01 3.997983e-01 17 4894525 4894543 19 + 1.915 1.984 0.232
ENSG00000141503 E053 173.0765130 0.0084651360 6.846487e-01 7.875924e-01 17 4894544 4894633 90 + 2.188 2.227 0.132
ENSG00000141503 E054 13.9059770 0.0017977635 9.127500e-04 3.658861e-03 17 4894634 4894857 224 + 1.320 1.040 -0.999
ENSG00000141503 E055 13.6252961 0.0488331245 4.702115e-02 1.038642e-01 17 4894858 4895074 217 + 1.293 1.045 -0.885
ENSG00000141503 E056 281.4585837 0.0002095087 6.219850e-01 7.388594e-01 17 4895075 4895242 168 + 2.402 2.430 0.095
ENSG00000141503 E057 277.7380170 0.0001636438 3.022549e-01 4.441063e-01 17 4895350 4895493 144 + 2.388 2.429 0.135
ENSG00000141503 E058 3.1322574 0.0051061248 1.125957e-01 2.093442e-01 17 4895494 4895697 204 + 0.745 0.518 -0.989
ENSG00000141503 E059 246.9680873 0.0003796190 6.904813e-05 3.754366e-04 17 4895698 4895832 135 + 2.284 2.402 0.396
ENSG00000141503 E060 6.1946551 0.0027665814 2.864206e-01 4.268023e-01 17 4895833 4896002 170 + 0.906 0.786 -0.463
ENSG00000141503 E061 189.5356074 0.0034440035 5.972045e-03 1.853394e-02 17 4896003 4896103 101 + 2.165 2.292 0.427
ENSG00000141503 E062 107.6916361 0.0031458560 3.808934e-02 8.751864e-02 17 4896193 4896204 12 + 1.932 2.044 0.375
ENSG00000141503 E063 238.0449631 0.0049283799 4.227827e-02 9.523415e-02 17 4896205 4896342 138 + 2.278 2.384 0.354
ENSG00000141503 E064 276.0473704 0.0015347858 1.488988e-03 5.600911e-03 17 4896429 4896588 160 + 2.337 2.449 0.375
ENSG00000141503 E065 241.9223096 0.0030203481 2.746878e-06 2.074415e-05 17 4896674 4896813 140 + 2.226 2.415 0.633
ENSG00000141503 E066 47.0148908 0.0004778242 7.846837e-03 2.339823e-02 17 4896814 4897203 390 + 1.733 1.611 -0.413
ENSG00000141503 E067 598.1816014 0.0073353159 4.612778e-08 5.010475e-07 17 4897204 4898073 870 + 2.567 2.824 0.856