ENSG00000141458

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269228 ENSG00000141458 HEK293_OSMI2_2hA HEK293_TMG_2hB NPC1 protein_coding protein_coding 26.71701 24.53814 20.80818 1.728492 0.1566312 -0.2377699 14.0171832 12.233998 10.7458507 1.40095221 0.62803399 -0.1869530 0.52291250 0.4959333 0.51690000 0.02096667 0.8952170535 0.0001269638 FALSE  
ENST00000587163 ENSG00000141458 HEK293_OSMI2_2hA HEK293_TMG_2hB NPC1 protein_coding retained_intron 26.71701 24.53814 20.80818 1.728492 0.1566312 -0.2377699 1.9743872 3.338184 0.9163039 0.30206062 0.13701605 -1.8538213 0.07390833 0.1378000 0.04406667 -0.09373333 0.0001331755 0.0001269638 FALSE  
ENST00000588867 ENSG00000141458 HEK293_OSMI2_2hA HEK293_TMG_2hB NPC1 protein_coding retained_intron 26.71701 24.53814 20.80818 1.728492 0.1566312 -0.2377699 1.4731990 1.525736 0.7782669 0.35709743 0.05190973 -0.9621739 0.05473750 0.0650000 0.03740000 -0.02760000 0.4676663208 0.0001269638 TRUE  
ENST00000591051 ENSG00000141458 HEK293_OSMI2_2hA HEK293_TMG_2hB NPC1 protein_coding protein_coding 26.71701 24.53814 20.80818 1.728492 0.1566312 -0.2377699 1.8711739 1.704283 0.5521355 0.10957778 0.55213548 -1.6086151 0.06848333 0.0708000 0.02693333 -0.04386667 0.1820313153 0.0001269638 FALSE  
MSTRG.15587.3 ENSG00000141458 HEK293_OSMI2_2hA HEK293_TMG_2hB NPC1 protein_coding   26.71701 24.53814 20.80818 1.728492 0.1566312 -0.2377699 1.5088564 1.536710 0.9773878 0.08841205 0.14687581 -0.6475136 0.05703333 0.0630000 0.04706667 -0.01593333 0.4674246656 0.0001269638 FALSE  
MSTRG.15587.9 ENSG00000141458 HEK293_OSMI2_2hA HEK293_TMG_2hB NPC1 protein_coding   26.71701 24.53814 20.80818 1.728492 0.1566312 -0.2377699 0.8175454 0.000000 1.5669323 0.00000000 0.78891123 7.3009769 0.03183750 0.0000000 0.07473333 0.07473333 0.1666688150 0.0001269638 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141458 E001 8.0034314 0.0454343234 3.367919e-01 4.806634e-01 18 23506184 23506642 459 - 0.855 1.001 0.552
ENSG00000141458 E002 32.1204992 0.0146046758 1.561466e-06 1.243286e-05 18 23521838 23522314 477 - 1.190 1.642 1.565
ENSG00000141458 E003 35.2795955 0.0203119615 7.120528e-04 2.941865e-03 18 23522315 23522906 592 - 1.313 1.650 1.157
ENSG00000141458 E004 34.4395448 0.0006232197 6.389469e-01 7.524642e-01 18 23528207 23529292 1086 - 1.517 1.557 0.139
ENSG00000141458 E005 5.4479052 0.0030694086 2.304466e-01 3.629920e-01 18 23529293 23529354 62 - 0.876 0.732 -0.570
ENSG00000141458 E006 12.6153495 0.0039288713 7.498029e-01 8.366531e-01 18 23529355 23529727 373 - 1.124 1.105 -0.070
ENSG00000141458 E007 95.5631930 0.0122231195 2.783875e-07 2.593159e-06 18 23531442 23531721 280 - 1.729 2.086 1.202
ENSG00000141458 E008 194.7292332 0.0062202554 1.427878e-09 2.056464e-08 18 23531722 23531945 224 - 2.083 2.377 0.983
ENSG00000141458 E009 284.4604978 0.0040858602 3.895812e-07 3.519667e-06 18 23531946 23532284 339 - 2.315 2.516 0.669
ENSG00000141458 E010 14.4308513 0.0012395001 3.783500e-04 1.690980e-03 18 23533202 23533354 153 - 0.935 1.288 1.277
ENSG00000141458 E011 193.5327914 0.0056428269 2.239292e-03 7.964163e-03 18 23533355 23533517 163 - 2.182 2.332 0.503
ENSG00000141458 E012 27.1021566 0.0265148042 3.961979e-01 5.399815e-01 18 23533518 23534445 928 - 1.377 1.484 0.369
ENSG00000141458 E013 134.1409375 0.0008867625 2.047183e-01 3.320429e-01 18 23534446 23534508 63 - 2.086 2.142 0.186
ENSG00000141458 E014 123.1471393 0.0003985031 1.378309e-01 2.450648e-01 18 23534509 23534559 51 - 2.047 2.109 0.207
ENSG00000141458 E015 0.5514428 0.0196789308 1.269810e-01 2.299445e-01 18 23534560 23534560 1 - 0.000 0.274 11.763
ENSG00000141458 E016 292.3974939 0.0008709207 2.270857e-01 3.589156e-01 18 23535469 23535700 232 - 2.432 2.474 0.143
ENSG00000141458 E017 126.9398210 0.0002611170 2.125645e-01 3.415755e-01 18 23536673 23536699 27 - 2.065 2.118 0.177
ENSG00000141458 E018 138.7528026 0.0002829310 1.198522e-01 2.197731e-01 18 23536700 23536741 42 - 2.098 2.159 0.204
ENSG00000141458 E019 174.1308348 0.0006570719 1.671057e-01 2.844374e-01 18 23536742 23536876 135 - 2.201 2.255 0.179
ENSG00000141458 E020 149.5356771 0.0008439675 1.053024e-01 1.985514e-01 18 23538542 23538671 130 - 2.127 2.192 0.218
ENSG00000141458 E021 1.0715652 0.1191649760 4.962241e-01 6.329202e-01 18 23538672 23538925 254 - 0.237 0.386 0.981
ENSG00000141458 E022 120.3807057 0.0006731295 8.752307e-02 1.713744e-01 18 23539355 23539470 116 - 2.028 2.100 0.241
ENSG00000141458 E023 5.6570201 0.0108468478 3.465355e-02 8.098752e-02 18 23539471 23539729 259 - 0.953 0.682 -1.066
ENSG00000141458 E024 5.2799053 0.0033019867 8.590620e-02 1.688332e-01 18 23539730 23539810 81 - 0.897 0.682 -0.855
ENSG00000141458 E025 64.9369120 0.0038717298 2.211187e-02 5.590513e-02 18 23539811 23539822 12 - 1.726 1.862 0.461
ENSG00000141458 E026 146.6169231 0.0002709836 9.057767e-04 3.634137e-03 18 23539823 23540001 179 - 2.086 2.200 0.380
ENSG00000141458 E027 126.9651644 0.0002458014 2.410987e-01 3.754721e-01 18 23540448 23540537 90 - 2.064 2.114 0.169
ENSG00000141458 E028 166.9672543 0.0002269259 2.169745e-01 3.467649e-01 18 23541068 23541208 141 - 2.226 2.205 -0.072
ENSG00000141458 E029 4.0611096 0.0038976930 1.335195e-06 1.079225e-05 18 23541209 23541305 97 - 0.986 0.274 -3.309
ENSG00000141458 E030 156.4150282 0.0004935192 2.382093e-02 5.944705e-02 18 23541306 23541433 128 - 2.216 2.162 -0.181
ENSG00000141458 E031 115.4961850 0.0003207223 3.105764e-01 4.529894e-01 18 23543455 23543569 115 - 2.068 2.046 -0.071
ENSG00000141458 E032 125.3667318 0.0002687953 4.718774e-03 1.514746e-02 18 23544344 23544526 183 - 2.135 2.058 -0.258
ENSG00000141458 E033 128.6323953 0.0030792734 4.684896e-02 1.035623e-01 18 23544960 23545149 190 - 2.137 2.071 -0.221
ENSG00000141458 E034 95.8674720 0.0081604263 1.167687e-01 2.153486e-01 18 23548006 23548108 103 - 2.015 1.943 -0.240
ENSG00000141458 E035 0.1817044 0.0393133674 6.038787e-01   18 23551546 23551626 81 - 0.000 0.111 10.178
ENSG00000141458 E036 108.9034369 0.0020988835 3.069911e-02 7.332881e-02 18 23551627 23551727 101 - 2.070 1.998 -0.241
ENSG00000141458 E037 175.7376650 0.0012258749 3.689633e-06 2.708214e-05 18 23554758 23554984 227 - 2.308 2.179 -0.430
ENSG00000141458 E038 0.1451727 0.0433203490 3.902476e-01   18 23554985 23554985 1 - 0.134 0.000 -11.068
ENSG00000141458 E039 181.7166608 0.0012070794 7.246930e-06 4.971427e-05 18 23556243 23556613 371 - 2.320 2.198 -0.409
ENSG00000141458 E040 10.3800558 0.0061465037 6.528237e-01 7.634667e-01 18 23556614 23556664 51 - 1.074 1.038 -0.131
ENSG00000141458 E041 71.4026646 0.0007217964 1.553720e-03 5.809913e-03 18 23557117 23557190 74 - 1.916 1.794 -0.413
ENSG00000141458 E042 126.4485003 0.0002909086 2.657360e-08 3.023416e-07 18 23560231 23560480 250 - 2.184 2.021 -0.547
ENSG00000141458 E043 110.4081013 0.0002511508 2.489306e-07 2.342497e-06 18 23561360 23561527 168 - 2.124 1.964 -0.539
ENSG00000141458 E044 120.8468197 0.0002921256 3.010014e-14 9.224169e-13 18 23568823 23568998 176 - 2.198 1.965 -0.780
ENSG00000141458 E045 82.3588114 0.0118350267 1.032361e-05 6.841732e-05 18 23572074 23572180 107 - 2.052 1.785 -0.897
ENSG00000141458 E046 71.6467660 0.0027671205 7.111593e-10 1.085632e-08 18 23573452 23573574 123 - 1.998 1.716 -0.950
ENSG00000141458 E047 3.7299978 0.0090376593 5.841998e-01 7.081747e-01 18 23576481 23576947 467 - 0.698 0.626 -0.306
ENSG00000141458 E048 67.6230651 0.0150284434 1.314319e-03 5.024796e-03 18 23586287 23586670 384 - 1.941 1.730 -0.711