ENSG00000141456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000574876 ENSG00000141456 HEK293_OSMI2_2hA HEK293_TMG_2hB PELP1 protein_coding protein_coding 87.55337 127.5981 63.03472 4.313039 0.2570906 -1.017273 73.53388 118.4689 47.23963 3.595455 0.256489 -1.326255 0.8117083 0.9287 0.7494333 -0.1792667 7.134614e-40 7.134614e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141456 E001 62.6043402 0.0182376725 2.255516e-02 5.683361e-02 17 4669774 4671139 1366 - 1.849 1.708 -0.478
ENSG00000141456 E002 15.9783148 0.0011527720 5.108185e-04 2.200299e-03 17 4671140 4671370 231 - 1.352 1.097 -0.903
ENSG00000141456 E003 9.8104981 0.0017461094 8.650980e-02 1.698221e-01 17 4671371 4671384 14 - 1.088 0.945 -0.525
ENSG00000141456 E004 16.6305370 0.0012277463 8.531994e-01 9.091199e-01 17 4671385 4671387 3 - 1.181 1.209 0.099
ENSG00000141456 E005 101.2245467 0.0039875273 3.500651e-06 2.582407e-05 17 4671388 4671415 28 - 1.722 2.022 1.010
ENSG00000141456 E006 582.2837410 0.0062906974 3.832853e-06 2.800318e-05 17 4671416 4671531 116 - 2.518 2.768 0.835
ENSG00000141456 E007 1284.7032154 0.0051061346 6.714368e-09 8.549650e-08 17 4671691 4671882 192 - 2.852 3.113 0.870
ENSG00000141456 E008 2048.3443251 0.0046977879 6.469966e-15 2.193478e-13 17 4671883 4672113 231 - 3.014 3.323 1.029
ENSG00000141456 E009 3024.4753960 0.0038801324 1.919840e-05 1.195975e-04 17 4672114 4672857 744 - 3.297 3.468 0.568
ENSG00000141456 E010 1065.7955664 0.0011979939 9.040254e-01 9.429287e-01 17 4672858 4673145 288 - 2.936 2.988 0.176
ENSG00000141456 E011 862.1024654 0.0007865549 9.705669e-01 9.855969e-01 17 4673250 4673456 207 - 2.845 2.895 0.167
ENSG00000141456 E012 11.0667487 0.0141843184 3.015321e-06 2.254938e-05 17 4673457 4673535 79 - 1.323 0.849 -1.725
ENSG00000141456 E013 573.0680161 0.0001405579 2.719618e-03 9.431664e-03 17 4673619 4673674 56 - 2.707 2.704 -0.011
ENSG00000141456 E014 796.3318269 0.0005712738 6.734923e-05 3.673377e-04 17 4674510 4674656 147 - 2.863 2.841 -0.073
ENSG00000141456 E015 344.5042045 0.0034488075 2.578485e-03 8.999709e-03 17 4674657 4674669 13 - 2.525 2.468 -0.190
ENSG00000141456 E016 885.3609002 0.0014315395 6.567833e-04 2.740515e-03 17 4674809 4674956 148 - 2.913 2.887 -0.086
ENSG00000141456 E017 688.6017407 0.0006747805 1.101136e-04 5.684729e-04 17 4675079 4675195 117 - 2.803 2.777 -0.085
ENSG00000141456 E018 6.4447106 0.0347520300 6.423173e-04 2.688223e-03 17 4675196 4675273 78 - 1.105 0.650 -1.758
ENSG00000141456 E019 427.3080177 0.0012297488 1.271242e-03 4.881585e-03 17 4675274 4675313 40 - 2.600 2.568 -0.109
ENSG00000141456 E020 385.4474096 0.0023321735 6.067738e-02 1.277721e-01 17 4675314 4675362 49 - 2.539 2.530 -0.028
ENSG00000141456 E021 36.4760363 0.0016136703 1.200660e-33 2.660367e-31 17 4675363 4675678 316 - 1.898 1.220 -2.324
ENSG00000141456 E022 23.2744298 0.0008612670 2.270655e-20 1.513458e-18 17 4675679 4675796 118 - 1.685 1.073 -2.128
ENSG00000141456 E023 547.4398144 0.0039873971 7.737460e-02 1.552647e-01 17 4675797 4675884 88 - 2.693 2.683 -0.035
ENSG00000141456 E024 638.9237462 0.0044665307 9.747535e-02 1.866299e-01 17 4676036 4676162 127 - 2.759 2.750 -0.027
ENSG00000141456 E025 16.3761349 0.0011079160 8.069324e-09 1.011720e-07 17 4676163 4676244 82 - 1.460 1.023 -1.545
ENSG00000141456 E026 658.9653165 0.0024097215 2.432007e-03 8.558305e-03 17 4676357 4676469 113 - 2.791 2.756 -0.116
ENSG00000141456 E027 434.8811399 0.0045310842 3.673892e-02 8.496914e-02 17 4676470 4676500 31 - 2.607 2.578 -0.097
ENSG00000141456 E028 396.1791858 0.0044104553 2.415403e-02 6.013099e-02 17 4676501 4676507 7 - 2.572 2.536 -0.119
ENSG00000141456 E029 498.1855020 0.0039584763 5.578386e-03 1.749683e-02 17 4676753 4676785 33 - 2.679 2.631 -0.159
ENSG00000141456 E030 464.1937174 0.0039216199 5.365567e-04 2.296635e-03 17 4676786 4676812 27 - 2.665 2.593 -0.238
ENSG00000141456 E031 657.4362091 0.0023770182 1.285748e-05 8.327843e-05 17 4682502 4682573 72 - 2.815 2.744 -0.235
ENSG00000141456 E032 11.8975213 0.0015220606 1.199451e-06 9.795764e-06 17 4682725 4682802 78 - 1.323 0.900 -1.528
ENSG00000141456 E033 795.4677100 0.0033243087 3.087638e-04 1.415198e-03 17 4682803 4682952 150 - 2.890 2.831 -0.198
ENSG00000141456 E034 2.2906702 0.0063533305 6.164956e-03 1.904621e-02 17 4683030 4683033 4 - 0.732 0.319 -2.018
ENSG00000141456 E035 2.9840634 0.0052639959 5.823551e-02 1.236056e-01 17 4683034 4683079 46 - 0.732 0.470 -1.171
ENSG00000141456 E036 0.4481018 0.1243695483 8.302481e-01 8.934838e-01 17 4683080 4683111 32 - 0.173 0.155 -0.192
ENSG00000141456 E037 519.3857057 0.0064066966 2.090186e-03 7.502878e-03 17 4690888 4690993 106 - 2.719 2.640 -0.262
ENSG00000141456 E038 6.0495998 0.0350950834 1.070432e-03 4.202645e-03 17 4690994 4691001 8 - 1.070 0.631 -1.716
ENSG00000141456 E039 33.3849290 0.0150958620 1.220996e-19 7.466562e-18 17 4691002 4691377 376 - 1.871 1.145 -2.499
ENSG00000141456 E040 434.4299005 0.0109132514 5.295268e-03 1.673576e-02 17 4691378 4691442 65 - 2.656 2.557 -0.331
ENSG00000141456 E041 0.5180316 0.0218887170 3.451003e-01 4.891822e-01 17 4691750 4691825 76 - 0.001 0.217 8.626
ENSG00000141456 E042 1.7295712 0.0083170516 5.431337e-01 6.737762e-01 17 4703730 4703862 133 - 0.296 0.437 0.829
ENSG00000141456 E043 541.3805420 0.0093396848 9.297386e-03 2.702636e-02 17 4703863 4704337 475 - 2.735 2.659 -0.252