ENSG00000141449

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000269218	ENSG00000141449	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GREB1L	protein_coding	protein_coding	5.079555	3.573012	7.386897	0.1911462	0.2785281	1.045747	0.59430701	0.72245709	0.5144558	0.48193408	0.2320906	-0.4819232	0.13988750	0.19550000	0.0704000	-0.12510000	0.84711478	0.01012292	FALSE	TRUE
ENST00000424526	ENSG00000141449	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GREB1L	protein_coding	protein_coding	5.079555	3.573012	7.386897	0.1911462	0.2785281	1.045747	2.12171415	1.49784692	2.7791665	0.76303697	0.2476612	0.8873441	0.41686250	0.43663333	0.3773667	-0.05926667	1.00000000	0.01012292	FALSE	TRUE
ENST00000578368	ENSG00000141449	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GREB1L	protein_coding	processed_transcript	5.079555	3.573012	7.386897	0.1911462	0.2785281	1.045747	0.18520681	0.01902778	0.5642192	0.01902778	0.1823980	4.3060957	0.02577083	0.00590000	0.0766000	0.07070000	0.01012292	0.01012292	FALSE	TRUE
ENST00000578955	ENSG00000141449	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GREB1L	protein_coding	retained_intron	5.079555	3.573012	7.386897	0.1911462	0.2785281	1.045747	0.57683811	0.49036592	0.6183470	0.09013425	0.1863938	0.3285779	0.12428333	0.13740000	0.0827000	-0.05470000	0.44624187	0.01012292	FALSE	TRUE
ENST00000579454	ENSG00000141449	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GREB1L	protein_coding	protein_coding	5.079555	3.573012	7.386897	0.1911462	0.2785281	1.045747	1.22057590	0.16009857	2.4981727	0.16009857	0.1054510	3.8821938	0.21832083	0.04426667	0.3386000	0.29433333	0.04281688	0.01012292	FALSE	TRUE
MSTRG.15548.4	ENSG00000141449	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GREB1L	protein_coding		5.079555	3.573012	7.386897	0.1911462	0.2785281	1.045747	0.06804151	0.54433205	0.0000000	0.49527856	0.0000000	-5.7926785	0.01775417	0.14203333	0.0000000	-0.14203333	0.19675354	0.01012292	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 52
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000141449	E001	0.2924217	0.0294538336	4.581759e-01		18	21242232	21242241	10	+	0.158	0.000	-10.130
ENSG00000141449	E002	2.3909052	0.1301703944	6.705769e-01	7.769908e-01	18	21242242	21242258	17	+	0.533	0.471	-0.300
ENSG00000141449	E003	3.4174957	0.0118820461	1.155888e-01	2.136866e-01	18	21242259	21242272	14	+	0.694	0.468	-1.027
ENSG00000141449	E004	7.5879864	0.0034617088	7.178519e-02	1.463192e-01	18	21242273	21242357	85	+	0.980	0.800	-0.687
ENSG00000141449	E005	7.3007510	0.0358149707	3.878152e-02	8.877850e-02	18	21242358	21242393	36	+	0.989	0.724	-1.028
ENSG00000141449	E006	0.4482035	0.0263093938	2.508911e-01	3.869969e-01	18	21363593	21363860	268	+	0.220	0.000	-13.387
ENSG00000141449	E007	6.2721739	0.0025872791	1.195235e-03	4.624401e-03	18	21366027	21366040	14	+	0.959	0.533	-1.748
ENSG00000141449	E008	14.1654590	0.0034279478	4.445688e-07	3.972184e-06	18	21366041	21366136	96	+	1.288	0.766	-1.930
ENSG00000141449	E009	8.6714862	0.0021713716	2.237070e-04	1.065083e-03	18	21383510	21383515	6	+	1.078	0.642	-1.696
ENSG00000141449	E010	32.7463783	0.0058784504	1.393478e-05	8.954587e-05	18	21383516	21383675	160	+	1.590	1.298	-1.006
ENSG00000141449	E011	44.2894446	0.0104861349	2.265633e-04	1.077106e-03	18	21384206	21384403	198	+	1.704	1.466	-0.811
ENSG00000141449	E012	37.9485890	0.0008017825	7.828278e-06	5.328939e-05	18	21395385	21395561	177	+	1.637	1.401	-0.807
ENSG00000141449	E013	43.5440718	0.0005481103	2.000615e-03	7.227783e-03	18	21401150	21401326	177	+	1.668	1.542	-0.431
ENSG00000141449	E014	34.8945946	0.0047640194	2.494403e-01	3.852577e-01	18	21403872	21403994	123	+	1.544	1.512	-0.111
ENSG00000141449	E015	11.7656295	0.0015075541	1.965776e-03	7.119286e-03	18	21434947	21435075	129	+	1.177	0.890	-1.053
ENSG00000141449	E016	30.3400232	0.0011678501	8.644169e-03	2.539642e-02	18	21439521	21439637	117	+	1.516	1.384	-0.454
ENSG00000141449	E017	35.3356517	0.0081562348	2.811035e-02	6.823265e-02	18	21440269	21440388	120	+	1.578	1.457	-0.413
ENSG00000141449	E018	36.1297314	0.0143140446	9.168556e-02	1.777664e-01	18	21441400	21441537	138	+	1.578	1.482	-0.329
ENSG00000141449	E019	36.0766885	0.0126938631	2.053215e-01	3.328284e-01	18	21444224	21444409	186	+	1.565	1.508	-0.196
ENSG00000141449	E020	26.5264697	0.0011142733	3.788196e-01	5.231119e-01	18	21449510	21449634	125	+	1.422	1.409	-0.045
ENSG00000141449	E021	33.7157476	0.0006164278	5.174871e-02	1.122712e-01	18	21449635	21449740	106	+	1.544	1.470	-0.253
ENSG00000141449	E022	29.6059290	0.0007490345	7.312158e-02	1.485110e-01	18	21449741	21449836	96	+	1.489	1.417	-0.247
ENSG00000141449	E023	27.0334437	0.0014933680	2.154471e-01	3.449612e-01	18	21451023	21451098	76	+	1.440	1.401	-0.134
ENSG00000141449	E024	23.8231882	0.0007779517	1.042667e-01	1.969844e-01	18	21451099	21451151	53	+	1.400	1.328	-0.249
ENSG00000141449	E025	0.0000000				18	21451152	21451370	219	+
ENSG00000141449	E026	43.2028443	0.0004980550	4.893877e-02	1.072695e-01	18	21452083	21452217	135	+	1.647	1.588	-0.204
ENSG00000141449	E027	0.9858280	0.0606616283	1.233459e-01	2.247307e-01	18	21452218	21452433	216	+	0.158	0.467	2.139
ENSG00000141449	E028	53.1795147	0.0004632331	1.790028e-01	2.998888e-01	18	21454366	21454563	198	+	1.722	1.706	-0.056
ENSG00000141449	E029	0.3686942	0.0260285869	6.205977e-01	7.377288e-01	18	21454564	21455130	567	+	0.086	0.171	1.143
ENSG00000141449	E030	0.2214452	0.0400583541	2.488742e-01		18	21468726	21468884	159	+	0.000	0.172	12.338
ENSG00000141449	E031	45.2157299	0.0013970063	2.607175e-02	6.408905e-02	18	21473031	21473211	181	+	1.670	1.593	-0.263
ENSG00000141449	E032	43.9067600	0.0031800036	3.778763e-01	5.221785e-01	18	21477164	21477356	193	+	1.639	1.637	-0.005
ENSG00000141449	E033	0.3332198	0.0287448649	6.220805e-01		18	21485369	21485619	251	+	0.086	0.171	1.141
ENSG00000141449	E034	38.7139732	0.0006377575	1.091089e-01	2.042344e-01	18	21485620	21485753	134	+	1.597	1.554	-0.150
ENSG00000141449	E035	61.5819103	0.0004308799	1.005289e-02	2.889092e-02	18	21490012	21490351	340	+	1.801	1.730	-0.241
ENSG00000141449	E036	36.0418909	0.0006877806	3.444179e-01	4.885109e-01	18	21495670	21495785	116	+	1.554	1.548	-0.023
ENSG00000141449	E037	49.7481987	0.0005074724	2.106036e-01	3.392532e-01	18	21496454	21496698	245	+	1.690	1.676	-0.049
ENSG00000141449	E038	83.8513414	0.0003720710	9.064960e-01	9.445843e-01	18	21499729	21500306	578	+	1.893	1.940	0.157
ENSG00000141449	E039	34.8732416	0.0006610343	4.890612e-01	6.265676e-01	18	21500540	21500642	103	+	1.501	1.593	0.315
ENSG00000141449	E040	49.1385274	0.0004736480	1.851758e-04	8.999052e-04	18	21505412	21505567	156	+	1.583	1.821	0.807
ENSG00000141449	E041	52.4267244	0.0004765613	1.387479e-06	1.117148e-05	18	21505810	21505949	140	+	1.590	1.874	0.962
ENSG00000141449	E042	60.0613953	0.0045447360	1.552047e-04	7.701976e-04	18	21508118	21508279	162	+	1.662	1.922	0.878
ENSG00000141449	E043	55.3321452	0.0082323861	1.233353e-02	3.433478e-02	18	21508387	21508591	205	+	1.649	1.862	0.719
ENSG00000141449	E044	6.5685465	0.0436420525	1.823674e-02	4.764652e-02	18	21508592	21508715	124	+	0.674	1.081	1.570
ENSG00000141449	E045	25.4306573	0.0007578408	2.033008e-02	5.217736e-02	18	21513821	21513902	82	+	1.440	1.318	-0.421
ENSG00000141449	E046	32.7230417	0.0016333233	1.426288e-03	5.394193e-03	18	21513903	21513986	84	+	1.565	1.400	-0.566
ENSG00000141449	E047	52.6524220	0.0005857345	1.418081e-04	7.113006e-04	18	21515417	21515644	228	+	1.762	1.614	-0.502
ENSG00000141449	E048	33.2697114	0.0006537892	1.303101e-01	2.345902e-01	18	21516613	21516754	142	+	1.536	1.491	-0.154
ENSG00000141449	E049	36.8709525	0.0007019948	8.013058e-01	8.733961e-01	18	21518034	21518172	139	+	1.546	1.582	0.122
ENSG00000141449	E050	26.6467247	0.0007599357	3.442631e-01	4.883353e-01	18	21518173	21518234	62	+	1.426	1.409	-0.057
ENSG00000141449	E051	34.1299642	0.0006407557	7.361560e-01	8.267191e-01	18	21520688	21520823	136	+	1.513	1.542	0.100
ENSG00000141449	E052	412.9185959	0.0067693062	1.091720e-11	2.260361e-10	18	21522658	21526112	3455	+	2.471	2.765	0.977

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000141449

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3