ENSG00000141449

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269218 ENSG00000141449 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1L protein_coding protein_coding 5.079555 3.573012 7.386897 0.1911462 0.2785281 1.045747 0.59430701 0.72245709 0.5144558 0.48193408 0.2320906 -0.4819232 0.13988750 0.19550000 0.0704000 -0.12510000 0.84711478 0.01012292 FALSE TRUE
ENST00000424526 ENSG00000141449 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1L protein_coding protein_coding 5.079555 3.573012 7.386897 0.1911462 0.2785281 1.045747 2.12171415 1.49784692 2.7791665 0.76303697 0.2476612 0.8873441 0.41686250 0.43663333 0.3773667 -0.05926667 1.00000000 0.01012292 FALSE TRUE
ENST00000578368 ENSG00000141449 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1L protein_coding processed_transcript 5.079555 3.573012 7.386897 0.1911462 0.2785281 1.045747 0.18520681 0.01902778 0.5642192 0.01902778 0.1823980 4.3060957 0.02577083 0.00590000 0.0766000 0.07070000 0.01012292 0.01012292 FALSE TRUE
ENST00000578955 ENSG00000141449 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1L protein_coding retained_intron 5.079555 3.573012 7.386897 0.1911462 0.2785281 1.045747 0.57683811 0.49036592 0.6183470 0.09013425 0.1863938 0.3285779 0.12428333 0.13740000 0.0827000 -0.05470000 0.44624187 0.01012292 FALSE TRUE
ENST00000579454 ENSG00000141449 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1L protein_coding protein_coding 5.079555 3.573012 7.386897 0.1911462 0.2785281 1.045747 1.22057590 0.16009857 2.4981727 0.16009857 0.1054510 3.8821938 0.21832083 0.04426667 0.3386000 0.29433333 0.04281688 0.01012292 FALSE TRUE
MSTRG.15548.4 ENSG00000141449 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1L protein_coding   5.079555 3.573012 7.386897 0.1911462 0.2785281 1.045747 0.06804151 0.54433205 0.0000000 0.49527856 0.0000000 -5.7926785 0.01775417 0.14203333 0.0000000 -0.14203333 0.19675354 0.01012292 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141449 E001 0.2924217 0.0294538336 4.581759e-01   18 21242232 21242241 10 + 0.158 0.000 -10.130
ENSG00000141449 E002 2.3909052 0.1301703944 6.705769e-01 7.769908e-01 18 21242242 21242258 17 + 0.533 0.471 -0.300
ENSG00000141449 E003 3.4174957 0.0118820461 1.155888e-01 2.136866e-01 18 21242259 21242272 14 + 0.694 0.468 -1.027
ENSG00000141449 E004 7.5879864 0.0034617088 7.178519e-02 1.463192e-01 18 21242273 21242357 85 + 0.980 0.800 -0.687
ENSG00000141449 E005 7.3007510 0.0358149707 3.878152e-02 8.877850e-02 18 21242358 21242393 36 + 0.989 0.724 -1.028
ENSG00000141449 E006 0.4482035 0.0263093938 2.508911e-01 3.869969e-01 18 21363593 21363860 268 + 0.220 0.000 -13.387
ENSG00000141449 E007 6.2721739 0.0025872791 1.195235e-03 4.624401e-03 18 21366027 21366040 14 + 0.959 0.533 -1.748
ENSG00000141449 E008 14.1654590 0.0034279478 4.445688e-07 3.972184e-06 18 21366041 21366136 96 + 1.288 0.766 -1.930
ENSG00000141449 E009 8.6714862 0.0021713716 2.237070e-04 1.065083e-03 18 21383510 21383515 6 + 1.078 0.642 -1.696
ENSG00000141449 E010 32.7463783 0.0058784504 1.393478e-05 8.954587e-05 18 21383516 21383675 160 + 1.590 1.298 -1.006
ENSG00000141449 E011 44.2894446 0.0104861349 2.265633e-04 1.077106e-03 18 21384206 21384403 198 + 1.704 1.466 -0.811
ENSG00000141449 E012 37.9485890 0.0008017825 7.828278e-06 5.328939e-05 18 21395385 21395561 177 + 1.637 1.401 -0.807
ENSG00000141449 E013 43.5440718 0.0005481103 2.000615e-03 7.227783e-03 18 21401150 21401326 177 + 1.668 1.542 -0.431
ENSG00000141449 E014 34.8945946 0.0047640194 2.494403e-01 3.852577e-01 18 21403872 21403994 123 + 1.544 1.512 -0.111
ENSG00000141449 E015 11.7656295 0.0015075541 1.965776e-03 7.119286e-03 18 21434947 21435075 129 + 1.177 0.890 -1.053
ENSG00000141449 E016 30.3400232 0.0011678501 8.644169e-03 2.539642e-02 18 21439521 21439637 117 + 1.516 1.384 -0.454
ENSG00000141449 E017 35.3356517 0.0081562348 2.811035e-02 6.823265e-02 18 21440269 21440388 120 + 1.578 1.457 -0.413
ENSG00000141449 E018 36.1297314 0.0143140446 9.168556e-02 1.777664e-01 18 21441400 21441537 138 + 1.578 1.482 -0.329
ENSG00000141449 E019 36.0766885 0.0126938631 2.053215e-01 3.328284e-01 18 21444224 21444409 186 + 1.565 1.508 -0.196
ENSG00000141449 E020 26.5264697 0.0011142733 3.788196e-01 5.231119e-01 18 21449510 21449634 125 + 1.422 1.409 -0.045
ENSG00000141449 E021 33.7157476 0.0006164278 5.174871e-02 1.122712e-01 18 21449635 21449740 106 + 1.544 1.470 -0.253
ENSG00000141449 E022 29.6059290 0.0007490345 7.312158e-02 1.485110e-01 18 21449741 21449836 96 + 1.489 1.417 -0.247
ENSG00000141449 E023 27.0334437 0.0014933680 2.154471e-01 3.449612e-01 18 21451023 21451098 76 + 1.440 1.401 -0.134
ENSG00000141449 E024 23.8231882 0.0007779517 1.042667e-01 1.969844e-01 18 21451099 21451151 53 + 1.400 1.328 -0.249
ENSG00000141449 E025 0.0000000       18 21451152 21451370 219 +      
ENSG00000141449 E026 43.2028443 0.0004980550 4.893877e-02 1.072695e-01 18 21452083 21452217 135 + 1.647 1.588 -0.204
ENSG00000141449 E027 0.9858280 0.0606616283 1.233459e-01 2.247307e-01 18 21452218 21452433 216 + 0.158 0.467 2.139
ENSG00000141449 E028 53.1795147 0.0004632331 1.790028e-01 2.998888e-01 18 21454366 21454563 198 + 1.722 1.706 -0.056
ENSG00000141449 E029 0.3686942 0.0260285869 6.205977e-01 7.377288e-01 18 21454564 21455130 567 + 0.086 0.171 1.143
ENSG00000141449 E030 0.2214452 0.0400583541 2.488742e-01   18 21468726 21468884 159 + 0.000 0.172 12.338
ENSG00000141449 E031 45.2157299 0.0013970063 2.607175e-02 6.408905e-02 18 21473031 21473211 181 + 1.670 1.593 -0.263
ENSG00000141449 E032 43.9067600 0.0031800036 3.778763e-01 5.221785e-01 18 21477164 21477356 193 + 1.639 1.637 -0.005
ENSG00000141449 E033 0.3332198 0.0287448649 6.220805e-01   18 21485369 21485619 251 + 0.086 0.171 1.141
ENSG00000141449 E034 38.7139732 0.0006377575 1.091089e-01 2.042344e-01 18 21485620 21485753 134 + 1.597 1.554 -0.150
ENSG00000141449 E035 61.5819103 0.0004308799 1.005289e-02 2.889092e-02 18 21490012 21490351 340 + 1.801 1.730 -0.241
ENSG00000141449 E036 36.0418909 0.0006877806 3.444179e-01 4.885109e-01 18 21495670 21495785 116 + 1.554 1.548 -0.023
ENSG00000141449 E037 49.7481987 0.0005074724 2.106036e-01 3.392532e-01 18 21496454 21496698 245 + 1.690 1.676 -0.049
ENSG00000141449 E038 83.8513414 0.0003720710 9.064960e-01 9.445843e-01 18 21499729 21500306 578 + 1.893 1.940 0.157
ENSG00000141449 E039 34.8732416 0.0006610343 4.890612e-01 6.265676e-01 18 21500540 21500642 103 + 1.501 1.593 0.315
ENSG00000141449 E040 49.1385274 0.0004736480 1.851758e-04 8.999052e-04 18 21505412 21505567 156 + 1.583 1.821 0.807
ENSG00000141449 E041 52.4267244 0.0004765613 1.387479e-06 1.117148e-05 18 21505810 21505949 140 + 1.590 1.874 0.962
ENSG00000141449 E042 60.0613953 0.0045447360 1.552047e-04 7.701976e-04 18 21508118 21508279 162 + 1.662 1.922 0.878
ENSG00000141449 E043 55.3321452 0.0082323861 1.233353e-02 3.433478e-02 18 21508387 21508591 205 + 1.649 1.862 0.719
ENSG00000141449 E044 6.5685465 0.0436420525 1.823674e-02 4.764652e-02 18 21508592 21508715 124 + 0.674 1.081 1.570
ENSG00000141449 E045 25.4306573 0.0007578408 2.033008e-02 5.217736e-02 18 21513821 21513902 82 + 1.440 1.318 -0.421
ENSG00000141449 E046 32.7230417 0.0016333233 1.426288e-03 5.394193e-03 18 21513903 21513986 84 + 1.565 1.400 -0.566
ENSG00000141449 E047 52.6524220 0.0005857345 1.418081e-04 7.113006e-04 18 21515417 21515644 228 + 1.762 1.614 -0.502
ENSG00000141449 E048 33.2697114 0.0006537892 1.303101e-01 2.345902e-01 18 21516613 21516754 142 + 1.536 1.491 -0.154
ENSG00000141449 E049 36.8709525 0.0007019948 8.013058e-01 8.733961e-01 18 21518034 21518172 139 + 1.546 1.582 0.122
ENSG00000141449 E050 26.6467247 0.0007599357 3.442631e-01 4.883353e-01 18 21518173 21518234 62 + 1.426 1.409 -0.057
ENSG00000141449 E051 34.1299642 0.0006407557 7.361560e-01 8.267191e-01 18 21520688 21520823 136 + 1.513 1.542 0.100
ENSG00000141449 E052 412.9185959 0.0067693062 1.091720e-11 2.260361e-10 18 21522658 21526112 3455 + 2.471 2.765 0.977