ENSG00000141446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269214 ENSG00000141446 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO1 protein_coding protein_coding 8.818818 3.745169 12.36208 0.2397004 0.4325508 1.720139 5.4703577 0.7957984 9.2534512 0.16405978 0.08849289 3.5230590 0.4821125 0.21523333 0.75070000 0.53546667 5.734586e-09 4.139428e-13 FALSE TRUE
ENST00000580101 ENSG00000141446 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO1 protein_coding processed_transcript 8.818818 3.745169 12.36208 0.2397004 0.4325508 1.720139 0.8757738 1.0693275 0.3938335 0.05197667 0.08483283 -1.4183000 0.1885917 0.28703333 0.03213333 -0.25490000 4.139428e-13 4.139428e-13   FALSE
ENST00000622333 ENSG00000141446 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO1 protein_coding protein_coding 8.818818 3.745169 12.36208 0.2397004 0.4325508 1.720139 1.2169996 1.6567107 0.9974236 0.32868681 0.54992040 -0.7263333 0.2243833 0.43586667 0.07890000 -0.35696667 1.704286e-01 4.139428e-13 FALSE TRUE
MSTRG.15551.5 ENSG00000141446 HEK293_OSMI2_2hA HEK293_TMG_2hB ESCO1 protein_coding   8.818818 3.745169 12.36208 0.2397004 0.4325508 1.720139 0.7037287 0.1115344 1.0856001 0.06231383 0.25682429 3.1722850 0.0540500 0.03116667 0.08660000 0.05543333 2.169817e-01 4.139428e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141446 E001 0.5879639 0.0244749188 5.709874e-01 6.973835e-01 18 21514777 21514890 114 - 0.151 0.246 0.866
ENSG00000141446 E002 2.2369857 0.2772440624 2.341065e-01 3.672729e-01 18 21529284 21529302 19 - 0.377 0.667 1.400
ENSG00000141446 E003 2.2088731 0.2551645229 5.040992e-01 6.399952e-01 18 21529303 21529309 7 - 0.402 0.593 0.934
ENSG00000141446 E004 157.3979563 0.0037501171 8.943353e-25 9.577679e-23 18 21529310 21530185 876 - 1.997 2.356 1.200
ENSG00000141446 E005 45.6061574 0.0005473528 1.944440e-04 9.401708e-04 18 21530186 21530378 193 - 1.515 1.716 0.686
ENSG00000141446 E006 41.9949548 0.0005847355 1.417835e-02 3.863091e-02 18 21530379 21530490 112 - 1.498 1.632 0.459
ENSG00000141446 E007 57.6859310 0.0005026100 5.732605e-01 6.992220e-01 18 21532473 21532660 188 - 1.670 1.608 -0.209
ENSG00000141446 E008 62.1382497 0.0004895255 6.615311e-03 2.022752e-02 18 21536042 21536185 144 - 1.720 1.518 -0.686
ENSG00000141446 E009 45.4550056 0.0005572882 4.090127e-02 9.270239e-02 18 21539920 21540009 90 - 1.583 1.404 -0.613
ENSG00000141446 E010 5.3776182 0.0072206072 9.569076e-01 9.769656e-01 18 21540577 21540700 124 - 0.714 0.682 -0.132
ENSG00000141446 E011 50.6819245 0.0005001549 9.514199e-03 2.757242e-02 18 21560859 21560990 132 - 1.631 1.417 -0.731
ENSG00000141446 E012 49.9409936 0.0005207810 1.086207e-01 2.035016e-01 18 21564203 21564317 115 - 1.615 1.476 -0.474
ENSG00000141446 E013 37.5110473 0.0006298860 3.835521e-01 5.277658e-01 18 21566146 21566206 61 - 1.486 1.391 -0.327
ENSG00000141446 E014 43.7926433 0.0125413023 5.306011e-01 6.631964e-01 18 21567980 21568094 115 - 1.549 1.470 -0.270
ENSG00000141446 E015 331.3041273 0.0207439180 2.925940e-05 1.745365e-04 18 21573314 21575430 2117 - 2.446 2.173 -0.911
ENSG00000141446 E016 27.9571856 0.0008009039 3.836413e-06 2.802595e-05 18 21575672 21575777 106 - 1.413 0.851 -2.031
ENSG00000141446 E017 29.9904331 0.0059184160 1.106556e-05 7.277935e-05 18 21584310 21584440 131 - 1.442 0.895 -1.960
ENSG00000141446 E018 9.0045932 0.0436352764 1.621357e-18 8.701450e-17 18 21593043 21593488 446 - 0.324 1.543 4.932
ENSG00000141446 E019 1.6637810 0.0089317747 9.300341e-05 4.891509e-04 18 21596953 21596999 47 - 0.151 0.801 3.674
ENSG00000141446 E020 5.4273844 0.0031050025 2.884115e-02 6.968598e-02 18 21600415 21600622 208 - 0.637 0.935 1.191
ENSG00000141446 E021 19.1755737 0.0238165524 6.196492e-01 7.369898e-01 18 21600623 21600884 262 - 1.215 1.120 -0.340