ENSG00000141429

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269195 ENSG00000141429 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT1 protein_coding protein_coding 35.31189 6.608827 58.70508 0.4493626 1.316023 3.149083 5.155134 0.09729577 16.03875 0.09729577 0.6339839 7.224724 0.1012833 0.01646667 0.2731667 0.2567 0.0051630106 0.0001248595 FALSE TRUE
MSTRG.15694.12 ENSG00000141429 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT1 protein_coding   35.31189 6.608827 58.70508 0.4493626 1.316023 3.149083 28.167467 6.46564805 37.71218 0.53254771 1.9530495 2.542317 0.8558625 0.97646667 0.6418667 -0.3346 0.0001248595 0.0001248595 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141429 E001 4.1152360 0.0319768009 3.231210e-02 7.645767e-02 18 35580763 35581116 354 + 0.567 0.000 -13.140
ENSG00000141429 E002 6.0382336 0.0083840188 5.830505e-03 1.816431e-02 18 35581117 35581303 187 + 0.695 0.000 -14.785
ENSG00000141429 E003 2.5099173 0.0077528628 1.105047e-01 2.062663e-01 18 35581304 35581305 2 + 0.421 0.000 -13.576
ENSG00000141429 E004 0.2924217 0.0273081002 1.000000e+00   18 35581662 35581739 78 + 0.077 0.000 -10.607
ENSG00000141429 E005 0.2924217 0.0273081002 1.000000e+00   18 35581740 35581753 14 + 0.077 0.000 -10.607
ENSG00000141429 E006 2.3605920 0.0063374248 1.264169e-01 2.291580e-01 18 35581754 35581833 80 + 0.405 0.000 -13.475
ENSG00000141429 E007 5.8390363 0.0027145929 6.213284e-02 1.302276e-01 18 35581834 35581862 29 + 0.669 0.322 -1.736
ENSG00000141429 E008 0.0000000       18 35627429 35627430 2 +      
ENSG00000141429 E009 1.4664887 0.1500304698 3.912911e-01 5.352115e-01 18 35627431 35627433 3 + 0.292 0.000 -12.613
ENSG00000141429 E010 3.5711907 0.0053992244 2.708491e-01 4.095063e-01 18 35627434 35627484 51 + 0.507 0.322 -1.012
ENSG00000141429 E011 0.0000000       18 35633953 35633953 1 +      
ENSG00000141429 E012 0.6017953 0.1611849306 1.000000e+00 1.000000e+00 18 35633954 35634050 97 + 0.142 0.000 -11.291
ENSG00000141429 E013 0.1472490 0.0439011681 6.496059e-01   18 35639331 35639391 61 + 0.040 0.000 -9.584
ENSG00000141429 E014 0.4375944 0.0263448549 1.000000e+00 1.000000e+00 18 35644424 35644471 48 + 0.110 0.000 -11.188
ENSG00000141429 E015 0.0000000       18 35646009 35646013 5 +      
ENSG00000141429 E016 0.0000000       18 35646014 35646177 164 +      
ENSG00000141429 E017 9.4907659 0.0017522785 1.104768e-01 2.062376e-01 18 35654560 35654571 12 + 0.831 0.633 -0.810
ENSG00000141429 E018 42.9397397 0.0066940904 7.881575e-02 1.576207e-01 18 35654572 35654655 84 + 1.425 1.362 -0.219
ENSG00000141429 E019 186.9469002 0.0022380675 4.899339e-05 2.766925e-04 18 35654656 35654801 146 + 2.054 1.965 -0.301
ENSG00000141429 E020 2.5036884 0.0061571431 1.103361e-01 2.060429e-01 18 35659858 35659930 73 + 0.421 0.000 -13.557
ENSG00000141429 E021 0.1515154 0.0432222562 6.491848e-01   18 35663611 35663627 17 + 0.040 0.000 -9.586
ENSG00000141429 E022 339.3166272 0.0001605648 2.419987e-09 3.340080e-08 18 35663628 35663802 175 + 2.310 2.228 -0.272
ENSG00000141429 E023 1.0352370 0.1229008797 5.792906e-01 7.042195e-01 18 35663803 35664517 715 + 0.224 0.000 -12.167
ENSG00000141429 E024 364.8499998 0.0055090633 2.962534e-04 1.364758e-03 18 35677591 35677757 167 + 2.339 2.282 -0.190
ENSG00000141429 E025 409.4826655 0.0002729848 1.256956e-05 8.164522e-05 18 35683391 35683598 208 + 2.384 2.373 -0.037
ENSG00000141429 E026 417.7301264 0.0002676383 1.048150e-08 1.286652e-07 18 35687016 35687186 171 + 2.397 2.344 -0.178
ENSG00000141429 E027 355.6682726 0.0001356685 6.899842e-08 7.229436e-07 18 35689173 35689290 118 + 2.328 2.274 -0.182
ENSG00000141429 E028 376.0149241 0.0001762635 1.498262e-04 7.462436e-04 18 35691012 35691192 181 + 2.347 2.350 0.012
ENSG00000141429 E029 0.1515154 0.0432222562 6.491848e-01   18 35691193 35691225 33 + 0.040 0.000 -9.586
ENSG00000141429 E030 258.4153626 0.0003293445 2.919859e-02 7.038625e-02 18 35692181 35692320 140 + 2.181 2.220 0.129
ENSG00000141429 E031 0.2955422 0.0293149112 1.204187e-01   18 35702805 35702896 92 + 0.040 0.322 3.509
ENSG00000141429 E032 256.0343923 0.0002303496 7.072869e-02 1.445499e-01 18 35702897 35702995 99 + 2.175 2.228 0.177
ENSG00000141429 E033 350.2810592 0.0001515486 9.409221e-01 9.668510e-01 18 35703509 35703643 135 + 2.304 2.419 0.386
ENSG00000141429 E034 1429.0224633 0.0199747841 2.443747e-06 1.865423e-05 18 35709624 35711834 2211 + 2.879 3.218 1.126