ENSG00000141425

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399022 ENSG00000141425 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD1A protein_coding protein_coding 63.21862 18.44836 103.9579 1.816828 2.270333 2.493792 36.6409076 10.594154 64.125826 0.6103198 2.78809968 2.596501 0.53714583 0.5788 0.61626667 0.03746667 6.055509e-01 4.395221e-42 FALSE TRUE
ENST00000585953 ENSG00000141425 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD1A protein_coding protein_coding 63.21862 18.44836 103.9579 1.816828 2.270333 2.493792 3.9154573 2.801626 3.908954 0.1834997 0.03131499 0.479064 0.12200833 0.1534 0.03763333 -0.11576667 1.458626e-21 4.395221e-42 FALSE FALSE
ENST00000588737 ENSG00000141425 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD1A protein_coding protein_coding 63.21862 18.44836 103.9579 1.816828 2.270333 2.493792 6.1786028 0.000000 13.465245 0.0000000 0.41319045 10.396096 0.05803750 0.0000 0.12973333 0.12973333 2.018653e-38 4.395221e-42 FALSE TRUE
ENST00000590898 ENSG00000141425 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD1A protein_coding protein_coding 63.21862 18.44836 103.9579 1.816828 2.270333 2.493792 0.7807983 2.360717 0.000000 0.5460712 0.00000000 -7.889180 0.04557083 0.1250 0.00000000 -0.12500000 4.395221e-42 4.395221e-42 TRUE TRUE
MSTRG.15699.14 ENSG00000141425 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD1A protein_coding   63.21862 18.44836 103.9579 1.816828 2.270333 2.493792 8.5750746 0.000000 10.854896 0.0000000 1.69532575 10.085459 0.10324583 0.0000 0.10520000 0.10520000 9.856146e-16 4.395221e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141425 E001 4.0917791 0.0273074965 1.694023e-01 2.874124e-01 18 35978828 35984341 5514 - 0.652 0.401 -1.199
ENSG00000141425 E002 0.2214452 0.0412658331 7.947782e-02   18 35984342 35984380 39 - 0.000 0.246 12.743
ENSG00000141425 E003 0.2214452 0.0412658331 7.947782e-02   18 35984381 35984386 6 - 0.000 0.246 12.743
ENSG00000141425 E004 0.3666179 0.0305847077 2.444518e-01 3.794058e-01 18 35984387 35984388 2 - 0.057 0.246 2.450
ENSG00000141425 E005 1.9532832 0.1725156406 7.510756e-02 1.517021e-01 18 35984389 35984528 140 - 0.264 0.696 2.244
ENSG00000141425 E006 3.0969563 0.0152002206 1.737072e-03 6.399031e-03 18 35984529 35984711 183 - 0.353 0.896 2.452
ENSG00000141425 E007 1.5039483 0.0117827806 9.536914e-03 2.762852e-02 18 35985338 35985386 49 - 0.192 0.681 2.769
ENSG00000141425 E008 0.7300161 0.0493792191 4.128817e-01 5.564549e-01 18 35988535 35988731 197 - 0.230 0.000 -12.691
ENSG00000141425 E009 0.2924217 0.0272726639 1.000000e+00   18 35988732 35988747 16 - 0.107 0.000 -11.602
ENSG00000141425 E010 0.2924217 0.0272726639 1.000000e+00   18 35988748 35988753 6 - 0.107 0.000 -11.602
ENSG00000141425 E011 1.0330470 0.0118046670 2.316588e-01 3.644288e-01 18 35988754 35988835 82 - 0.296 0.000 -13.731
ENSG00000141425 E012 36.7448459 0.0236408638 1.004612e-05 6.672544e-05 18 35989824 35989885 62 - 1.335 1.824 1.672
ENSG00000141425 E013 402.9401909 0.0183494859 1.086781e-11 2.250627e-10 18 35989886 35990202 317 - 2.346 2.858 1.707
ENSG00000141425 E014 510.4928776 0.0063685040 8.965573e-07 7.519816e-06 18 35990203 35990525 323 - 2.540 2.791 0.838
ENSG00000141425 E015 272.0640109 0.0001578985 1.306540e-02 3.606431e-02 18 35990526 35990595 70 - 2.304 2.415 0.370
ENSG00000141425 E016 2451.3415440 0.0001362451 8.553196e-12 1.801620e-10 18 35990596 35993039 2444 - 3.280 3.264 -0.055
ENSG00000141425 E017 220.6252301 0.0022906218 2.196209e-05 1.348497e-04 18 35993040 35993101 62 - 2.255 2.122 -0.443
ENSG00000141425 E018 487.5751704 0.0027907673 8.623478e-11 1.539186e-09 18 35993102 35993300 199 - 2.604 2.421 -0.607
ENSG00000141425 E019 0.7406253 0.0153892559 4.001848e-01 5.438815e-01 18 35995841 35995875 35 - 0.230 0.000 -13.145
ENSG00000141425 E020 43.7595418 0.0011331028 5.309304e-10 8.279131e-09 18 36024889 36025598 710 - 1.432 1.846 1.406
ENSG00000141425 E021 9.2266651 0.0183787159 7.472944e-02 1.510979e-01 18 36025599 36025600 2 - 0.845 1.119 1.017
ENSG00000141425 E022 31.8041278 0.0006267678 4.167792e-27 5.426638e-25 18 36025601 36025678 78 - 1.158 1.886 2.505
ENSG00000141425 E023 18.7050923 0.0011938245 1.537783e-23 1.445082e-21 18 36025679 36025690 12 - 0.878 1.721 2.978
ENSG00000141425 E024 149.4319904 0.0002661963 1.189679e-106 4.252476e-103 18 36025691 36026895 1205 - 1.821 2.534 2.386
ENSG00000141425 E025 12.3360858 0.0015424863 3.738061e-08 4.131648e-07 18 36026896 36026899 4 - 0.845 1.429 2.107
ENSG00000141425 E026 485.2946190 0.0004649135 2.573699e-02 6.339860e-02 18 36026900 36027075 176 - 2.576 2.568 -0.024
ENSG00000141425 E027 338.1313109 0.0001594857 1.490588e-02 4.027433e-02 18 36027184 36027310 127 - 2.421 2.403 -0.059
ENSG00000141425 E028 1.6231864 0.0095520905 7.975202e-01 8.708081e-01 18 36027311 36028190 880 - 0.325 0.402 0.448
ENSG00000141425 E029 383.6377769 0.0024578594 1.148469e-04 5.901911e-04 18 36030808 36030905 98 - 2.487 2.396 -0.305
ENSG00000141425 E030 420.0968329 0.0001726646 1.465869e-13 4.069526e-12 18 36030991 36031097 107 - 2.533 2.397 -0.455
ENSG00000141425 E031 335.1404326 0.0001662370 1.525056e-11 3.082113e-10 18 36033708 36033751 44 - 2.436 2.296 -0.468
ENSG00000141425 E032 355.9999550 0.0001715722 1.048881e-12 2.565290e-11 18 36033752 36033801 50 - 2.463 2.317 -0.486
ENSG00000141425 E033 282.9415163 0.0001725626 8.436691e-14 2.424247e-12 18 36033802 36033837 36 - 2.369 2.187 -0.609
ENSG00000141425 E034 35.2619538 0.0016396835 1.936914e-01 3.184188e-01 18 36040807 36040865 59 - 1.463 1.403 -0.206
ENSG00000141425 E035 0.0000000       18 36052875 36052920 46 -      
ENSG00000141425 E036 2.0860645 0.0638161514 7.258826e-01 8.190466e-01 18 36062978 36063075 98 - 0.404 0.513 0.554
ENSG00000141425 E037 0.0000000       18 36063993 36064424 432 -      
ENSG00000141425 E038 421.7068171 0.0002632991 1.613224e-10 2.748137e-09 18 36067254 36067576 323 - 2.532 2.419 -0.377