ENSG00000141401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269159 ENSG00000141401 HEK293_OSMI2_2hA HEK293_TMG_2hB IMPA2 protein_coding protein_coding 20.39454 33.77614 13.67318 1.80581 0.7498933 -1.304028 6.587641 9.715446 5.9744679 1.91379899 0.38697894 -0.7005414 0.31759583 0.28326667 0.43666667 0.15340000 0.071304924 0.003894883 FALSE TRUE
ENST00000588167 ENSG00000141401 HEK293_OSMI2_2hA HEK293_TMG_2hB IMPA2 protein_coding retained_intron 20.39454 33.77614 13.67318 1.80581 0.7498933 -1.304028 1.159722 1.307475 0.7753089 0.02620072 0.05561441 -0.7464429 0.06145417 0.03883333 0.05656667 0.01773333 0.180646733 0.003894883 FALSE FALSE
ENST00000588927 ENSG00000141401 HEK293_OSMI2_2hA HEK293_TMG_2hB IMPA2 protein_coding protein_coding 20.39454 33.77614 13.67318 1.80581 0.7498933 -1.304028 8.493711 17.102445 4.4426449 0.41726312 0.32201533 -1.9423114 0.40315833 0.51056667 0.32426667 -0.18630000 0.003894883 0.003894883 FALSE TRUE
ENST00000589374 ENSG00000141401 HEK293_OSMI2_2hA HEK293_TMG_2hB IMPA2 protein_coding retained_intron 20.39454 33.77614 13.67318 1.80581 0.7498933 -1.304028 1.368720 2.125083 0.6447539 0.11855559 0.25829409 -1.7052673 0.06985000 0.06296667 0.04933333 -0.01363333 0.690457378 0.003894883 FALSE FALSE
ENST00000590107 ENSG00000141401 HEK293_OSMI2_2hA HEK293_TMG_2hB IMPA2 protein_coding nonsense_mediated_decay 20.39454 33.77614 13.67318 1.80581 0.7498933 -1.304028 1.219694 1.441307 1.1298697 0.37680582 0.05813248 -0.3484836 0.06755833 0.04420000 0.08366667 0.03946667 0.216047816 0.003894883 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000141401 E001 0.0000000       18 11981025 11981036 12 +      
ENSG00000141401 E002 0.1482932 0.0420595504 1.000000e+00   18 11981037 11981130 94 + 0.000 0.081 8.920
ENSG00000141401 E003 0.5117019 0.0232644600 3.513148e-01 0.4955306994 18 11981131 11981205 75 + 0.000 0.209 12.676
ENSG00000141401 E004 0.2987644 0.0274956018 4.721604e-02   18 11981428 11981464 37 + 0.307 0.000 -14.587
ENSG00000141401 E005 3.3828579 0.0048698614 5.156798e-01 0.6503155092 18 11981465 11981476 12 + 0.662 0.566 -0.424
ENSG00000141401 E006 12.6712550 0.0015227750 3.923209e-01 0.5362714884 18 11981477 11981506 30 + 1.125 1.046 -0.286
ENSG00000141401 E007 16.8939265 0.0013902361 1.137634e-01 0.2110079269 18 11981507 11981515 9 + 1.278 1.146 -0.468
ENSG00000141401 E008 21.9825981 0.0015275202 4.213476e-02 0.0949686374 18 11981516 11981526 11 + 1.400 1.249 -0.530
ENSG00000141401 E009 36.3570314 0.0008433688 8.581678e-05 0.0004554624 18 11981527 11981610 84 + 1.665 1.435 -0.787
ENSG00000141401 E010 43.1025096 0.0021775780 1.500142e-03 0.0056361546 18 11981611 11981669 59 + 1.706 1.527 -0.610
ENSG00000141401 E011 44.0112678 0.0005938005 7.907390e-03 0.0235451233 18 11981670 11981693 24 + 1.688 1.547 -0.481
ENSG00000141401 E012 51.9909012 0.0021359001 8.007687e-03 0.0237973323 18 11981694 11981765 72 + 1.756 1.618 -0.466
ENSG00000141401 E013 32.7697452 0.0006688314 1.262016e-01 0.2288662573 18 11999054 11999061 8 + 1.530 1.438 -0.317
ENSG00000141401 E014 82.6700447 0.0003407692 1.816463e-01 0.3032994273 18 11999062 11999135 74 + 1.892 1.844 -0.162
ENSG00000141401 E015 94.4529734 0.0002981329 4.731693e-01 0.6121861135 18 11999136 11999187 52 + 1.931 1.911 -0.067
ENSG00000141401 E016 3.2336041 0.0925203037 1.532818e-01 0.2661421103 18 12008333 12008591 259 + 0.307 0.622 1.634
ENSG00000141401 E017 79.9717982 0.0003897708 6.991844e-01 0.7989913534 18 12009883 12009899 17 + 1.854 1.845 -0.028
ENSG00000141401 E018 99.5389351 0.0006765827 1.665154e-01 0.2836784745 18 12009900 12009930 31 + 1.975 1.930 -0.153
ENSG00000141401 E019 118.1017478 0.0004007403 1.661764e-01 0.2832303704 18 12009931 12009987 57 + 2.043 2.003 -0.136
ENSG00000141401 E020 1.8015668 0.0089214012 2.328999e-01 0.3658683697 18 12009988 12010221 234 + 0.552 0.350 -1.054
ENSG00000141401 E021 115.5790935 0.0012734120 1.845836e-01 0.3069566384 18 12012170 12012215 46 + 2.031 1.988 -0.142
ENSG00000141401 E022 5.3516353 0.0467036758 4.705291e-02 0.1039173792 18 12012216 12012349 134 + 0.965 0.667 -1.171
ENSG00000141401 E023 145.2197475 0.0002985980 1.575869e-02 0.0421916139 18 12014265 12014373 109 + 2.029 2.119 0.301
ENSG00000141401 E024 2.6026797 0.0327311556 2.336678e-01 0.3667547922 18 12017614 12018285 672 + 0.307 0.544 1.281
ENSG00000141401 E025 0.1817044 0.0399022133 1.000000e+00   18 12021702 12021822 121 + 0.000 0.081 10.957
ENSG00000141401 E026 139.2943273 0.0002673605 6.461027e-03 0.0198231849 18 12028043 12028151 109 + 2.003 2.105 0.343
ENSG00000141401 E027 21.8326542 0.0008629282 2.860752e-01 0.4264553616 18 12028152 12028607 456 + 1.354 1.277 -0.267
ENSG00000141401 E028 13.4782230 0.0013838558 9.165380e-01 0.9512513449 18 12028608 12028841 234 + 1.108 1.105 -0.009
ENSG00000141401 E029 209.9019491 0.0005808466 1.608851e-03 0.0059897035 18 12028842 12028993 152 + 2.183 2.284 0.335
ENSG00000141401 E030 393.9843300 0.0025845535 6.953525e-04 0.0028820436 18 12030343 12030877 535 + 2.452 2.557 0.350